Browsing by Author "Edara, Venkata Viswanadh"
Now showing items 1-4 of 4
-
Astrocyte HIV-1 Proviral Reservoirs in HAND
Edara, Venkata Viswanadh (2019-03-05)Purpose: Even though astrocytes are restrictively infected with HIV-1, they are capable of producing neurotoxic viral proteins and proinflammatory mediators. This can significantly aggravate the pathogenesis of HIV-associated ... -
IL-1Beta autocrine loop differentially regulates astrocyte inflammatory responses in HAND
Edara, Venkata Viswanadh (2016-03-23)Hypothesis: HIV-1 infection of the central nervous system (CNS) impairs brain function and leads to HIV associated neurocognitive disorders (HAND). Astrocytes are the most abundant cell type in CNS and provide structural ... -
Red/Green Astrocytes Mimic CNS Viral Reservoirs in Post ART HAND: Implications for Meth Abuse
Edara, Venkata Viswanadh (2017-03-14)Hypothesis: Though anti-retroviral therapy (ART) has increased the life expectancy of HIV-1 infected individuals, the quest for eradication of latent viral reservoirs continues. Methamphetamine (Meth) abuse and HIV-1 ... -
Targeting Astrocyte HIV-1 Proviral Reservoirs in HAND
Edara, Venkata Viswanadh (2018-03-14)Purpose: Although antiretroviral therapy (ART) has greatly reduced the incidence of HIV-associated dementia (HAD), nearly 50-70% of HIV-1 infected individuals develop HIV-associated neurocognitive disorders (HAND). Between ...