Browsing by Author "Fan, Yan"
Now showing items 1-4 of 4
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Astrocyte-mediated HIV-1 Tat neurotoxicity and its molecular mechanisms: astrocyte activation and impaired neurogenesis
Fan, Yan (2016-08-01)Human immunodeficiency virus type 1 (HIV-1) invasion of the central nervous system (CNS) often causes motor and cognitive dysfunction, which is termed HIV-associated neurocognitive disorders (HAND). Although the introduction ... -
Chemical Reprogramming of Mouse and Human Müller glia into Retinal Ganglion-Like Cells (RGCs)
Fan, Yan (2019-03-05)Chemical Reprogramming of Mouse and Human Müller glia into Retinal Ganglion-Like Cells (RGCs) Yan Fan, Wei Zhang, Sai Chavala Department of Pharmacology and Neuroscience, Graduate School of Biomedical Sciences, UNT Health ... -
HIV-1 Tat adversely affects neurogenesis through Notch signaling
Fan, Yan (2016-03-23)Alterations in adult neurogenesis appear to be a common hallmark in several neurodegenerative diseases including human immunodeficiency virus type 1 (HIV-1)-associated neurocognitive disorder (HAND). HIV-1 Tat is a major ... -
HIV-1 TAT INDUCES ER STRESS IN ASTROCYTES AND CAUSES NEUROTOXICITY THROUGH GFAP ACTIVATION AND AGGREGATION
Fan, Yan (2013-04-12)Purpose: HIV-1 Tat is a major pathogenic factor for HIV-associated neurodegenerative diseases. One of the consistent hallmarks of HIV-1 infection of the central nervous system (CNS) is astrocytosis, which is characterized ...