Browsing by Author "Gardner, Jennifer"
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Innate immune system stimulation during pregnancy induces upregulation of thromboxane synthesis in rat maternal heart
Tucker, Selina; Cushen, Spencer; Bradshaw, Jessica; Gardner, Jennifer; Ricci, Contessa; Dick, Gregory; Tune, Johnathan; Goulopoulou, Styliani; 0000-0002-7959-8716 (Tucker, Selina); 0000-0003-3784-9190 (Gardner, Jennifer) (2022)Purpose: Infections during pregnancy are associated with adverse clinical outcomes. We previously showed that exposure to immunostimulatory ODN2395 (synthetic Toll-like receptor 9 agonist) during pregnancy induces maternal ... -
Oxidative Stress and Release of Cell-free Mitochondrial DNA from Trophoblast Cells
Gardner, Jennifer; Cushen, Spencer; Bradshaw, Jessica; Garlotte, Isabelle; Phillips, Nicole; Cunningham, Rebecca; Goulopoulou, Styliani; 0000-0003-3784-9190 (Gardner, Jennifer) (2022)Cell free mitochondrial DNA (mtDNA) is an indicator of cellular stress and systemic inflammation. These properties are accentuated when mtDNA undergoes oxidative damage. In addition, toll-like receptor 9 (TLR9), a receptor ... -
Rats with Placental Ischemia and Preeclampsia-like Symptoms Have Increased Circulating Cell-free Mitochondrial DNA
Gardner, Jennifer (2020)Preeclampsia (PE) is a hypertensive disorder of pregnancy, which is characterized by placental mitochondrial dysfunction. Increased circulating cell-free mitochondrial DNA (mtDNA) has been also reported in PE. Animal models ... -
Rats with placental ischemia and preeclampsia-like symptoms have increased circulating cell-free mtDNA
Gardner, Jennifer (2021)Preeclampsia (PE) is a hypertensive disorder of pregnancy, which is characterized by placental mitochondrial dysfunction. Increased circulating cell-free mitochondrial DNA (mtDNA) has been also reported in PE. Animal models ... -
The impact of healthy pregnancy on maternal cognitive impairment in Sprague Dawley rats
Wilson, E. Nicole; Bradshaw, Jessica; Tucker, Selina; Gardner, Jennifer; Goulopoulou, Styliani; Cunningham, Rebecca; 0000-0002-7959-8716 (Tucker, Selina); 0000-0003-3784-9190 (Gardner, Jennifer) (2022)Introduction/Background: There is clinical evidence of impaired attention, learning, and memory in pregnant women during pregnancy and in the postpartum period, suggesting an association between pregnancy and maternal ...