Now showing items 1-2 of 2

    • Imputation Accuracy of Apolipoprotein E ε Alleles in Genome-wide arrays and real-time SNP Genotyping assays 

      Subasinghe, Kumudu; Garlotte, Isabelle; O'Bryant, Sid; Barber, Robert; Phillips, Nicole; 0000-0001-9429-1993 (Subasinghe, Kumudu) (2022)
      Purpose: The vast majority of the established genetic-based risk for late-onset Alzheimer's disease (AD) is attributable to variation within the apolipoprotein E (APOE) gene. This gene, which encodes a protein implicated ...
    • Oxidative Stress and Release of Cell-free Mitochondrial DNA from Trophoblast Cells 

      Gardner, Jennifer; Cushen, Spencer; Bradshaw, Jessica; Garlotte, Isabelle; Phillips, Nicole; Cunningham, Rebecca; Goulopoulou, Styliani; 0000-0003-3784-9190 (Gardner, Jennifer) (2022)
      Cell free mitochondrial DNA (mtDNA) is an indicator of cellular stress and systemic inflammation. These properties are accentuated when mtDNA undergoes oxidative damage. In addition, toll-like receptor 9 (TLR9), a receptor ...