Browsing by Author "Maddineni, Prabhavathi"
Now showing items 1-5 of 5
-
Glucocorticoid-induced glaucomatous neurodegeneration is associated with demyelination of optic nerve axons and infiltration of immune cells
Maddineni, Prabhavathi (2019-03-05)Purpose: Ocular hypertension (OHT) is a serious side effect of glucocorticoid (GC) therapy and if untreated, it can leads to secondary open-angle glaucoma. However, the precise mechanism of GC-induced glaucomatous ... -
Glucocorticoid-induced ocular hypertension alters synaptic plasticity and neurotransmission during the progression of glaucomatous neurodegeneration
Maddineni, Prabhavathi; 0000-0002-6928-254X (2021)Purpose: Elevated intraocular pressure (IOP) is the major risk factor for Primary Open Angle Glaucoma (POAG). The neurodegeneration in POAG extends beyond the eye into the visual centers of the brain (VCB). Unfortunately, ... -
Glucocorticoid-induced ocular hypertension leads to progressive retinal ganglion cell loss, impaired axonal transport and optic nerve degeneration in mice
Maddineni, Prabhavathi (2018-03-14)Purpose: Ocular hypertension (OHT) and secondary iatrogenic open angle glaucoma are the serious side effects of glucocorticoid (GC) therapy, which is used widely to treat various immune mediated diseases. We have previously ... -
Overexpression of ATF-4 in trabecular meshwork causes elevation of intra ocular pressure and reduction of outflow facility in a CHOP dependent manner
Maddineni, Prabhavathi (2017-03-14)Purpose: Primary open-angle glaucoma (POAG) has been primarily associated with reduced aqueous humor outflow facility through trabecular meshwork (TM) and elevated intraocular pressure (IOP). Studies based on both human ... -
Sodium 4-phenylbyrate rescues glucocorticoid-induced ocular hypertension by reducing abnormal ECM deposition in the TM via activation of MMP9
Maddineni, Prabhavathi (2020)Purpose: Ocular hypertension (OHT) is a serious side effect of glucocorticoid (GC) therapy and if left undiagnosed, it leads to glaucoma. Previously, we have shown that, sodium-4-phenylbutyrate (PBA) rescues GC-induced ...