Browsing by Author "Qunies, Alshaima'a"
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Design and discovery of new tool compounds for studying the role of Slack potassium channels in malignant migrating partial seizure of infancy
Qunies, Alshaima'a; Spitznagel, Brittany; Du, Yu; Weaver, C.; Emmitte, Kyle (2022)Purpose: Slack channels are sodium-activated potassium channels encoded by the KCNT1 gene, and are key regulators of electrical activity in the central nervous system. Slack channels belong to the Slo family of potassium ... -
Discovery of Small Molecule Slack Inhibitors for the Treatment of MMPSI: SAR Development in the Eastern Region of Hit Compound VU0606170
Qunies, Alshaima'a (2020)Introduction: Malignant Migrating Partial Seizures of Infancy (MMPSI) is a severe form of epilepsy without effective treatments. Slack channels are sodium-activated potassium channels, which are critical regulators of ... -
Discovery of Small Molecule Slack Inhibitors for the Treatment of MMPSI: SAR Development in the Eastern Region of Hit Compound VU0606170
Qunies, Alshaima'a (2021)Purpose: Malignant Migrating Partial Seizures of Infancy (MMPSI) is a severe form of pharmacoresistant epilepsy. Slack channels are sodium-activated potassium channels, which are critical regulators of electrical activity ... -
Library synthesis of Slack potassium channel activators based on a high-throughput screening hit
Nguyen, Dalena; Qunies, Alshaima'a; Du, Yu; Weaver, C.; Emmitte, Kyle; 0000-0002-6924-9395 (Nguyen, Dalena) (2022)Introduction: Fragile X syndrome (FXS) is an X-linked disorder that is associated with cognitive disabilities. Previous studies have shown an association between a mutation in the FMR1 gene and FXS. The mutation is an ...