Browsing by Author "Van Treuren, Timothy"
Now showing items 1-4 of 4
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CRISPR deletion of MIEN1 in Triple Negative Breast Cancer
Van Treuren, Timothy (2017-03-14)Purpose/Objective: Triple negative breast cancer (TNBC), which accounts for 15-20% of all breast cancer diagnoses, is the most aggressive subtype of breast cancer. The propensity of TNBC to metastasize to vital organs, ... -
Effect of CRISPR MIEN1 knockout in metastatic breast cancer cells
Van Treuren, Timothy (2018-12)Migration and Invasion Enhancer 1 (MIEN1) is an oncogene which is involved in facilitating the migration and invasion of cancer cells through actin dynamics and gene expression. Increased MIEN1 expression in many types of ... -
MIEN1 Regulates Breast Cancer Cell Migration and Invasion by Altering Cytoskeletal Dynamics Through Focal Adhesion Kinase and N-WASP Signaling
Van Treuren, Timothy (2018-03-14)Purpose: Triple negative breast cancer (TNBC), accounts for approximately 15-20% of all breast cancer diagnoses. This is the most aggressive breast cancer subtype and is characterized by a lack of known receptors associated ... -
Phosphorylated Annexin A2 at Tyrosine 23 Regulates Exosome Release and Biogenesis in Triple Negative Breast Cancer
Desai, Priyanka Prakash; Tripathi, Amit Kumar; Donkor, Michael; Thyagarajan, Srikantha; Jones, Harlan; Van Treuren, Timothy; Lampe, Jana; Chaudhary, Panka J.; Vishwanatha, Jamboor (2022)Purpose: Exosomes are highly involved in the progression of diverse diseases. Targeting exosome biogenesis and release is a potential strategy for the treatment of the disease like cancer which urges an improved understanding ...