Browsing by Author "Zhang, Hongxia"
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Blood Inflammatory Exosomes with Age Prime Microglia through Complement Signaling for Negative Stroke Outcomes
Zhang, Hongxia; 0000-0003-1594-6707 (2020-05)The systemic inflammatory milieu plays an important role in the age-related decline of functional integrity, but its contribution to age-related disease (e.g., stroke) remains largely unknown. Here, we found that activated ... -
Circulating exosomes amplify microglial responses and exacerbate synapse loss in aged ischemic stroke brain via a Complement Signaling
Zhang, Hongxia (2020)Background: Aging is associated with striking increases in the incidences of stroke, which remains leading cause of disability in the US. Despite progress in understanding molecular mechanisms of neuronal cell death after ... -
Differential Effects of Young and Old Serum Exosomes on Ischemic Stroke Outcomes in Aged Rats
Zhang, Hongxia (2019-03-05)Background: Aging is associated with striking increases in the incidences of stroke and neurodegenerative diseases, both of which are major causes of disability among those age 70 years and older in the United States. ... -
Histone deacetylase signaling plays a critical role in age-related decrease in adult neurogenesis
Zhang, Hongxia (2018-03-14)Aging is associated with a striking increase in the incidence of stroke and neurodegenerative diseases, both of which are major causes of disability among those age 70 years and older in the United States. Adult neural ...