School of Biomedical Sciences
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Open Access scholarship from the School of Biomedical Sciences at the University of North Texas Health Science Center at Fort Worth.
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Centralizing prescreening data collection to inform data-driven approaches to clinical trial recruitment
(BioMed Central Ltd., 2023-05-03)BACKGROUND: Recruiting to multi-site trials is challenging, particularly when striving to ensure the randomized sample is demographically representative of the larger disease-suffering population. While previous studies ... -
A Celebration of the Extraordinary Life of Late Professor Tatiana V. Serebrovskaya (Kyiv, Ukraine) in Advancing Hypoxia Science and Medicine
(Mary Ann Liebert, Inc., 2022-08-03) -
Demographic and Psychosocial Correlates of COVID-19 Vaccination Status among a Statewide Sample in Texas
(MDPI, 2023-04-28)The COVID-19 pandemic has been a global public health concern since early 2020 and has required local and state-level responses in the United States. There were several Food and Drug Administration (FDA) approved vaccines ... -
Novel role of HIV-1 Nef in regulating the ubiquitination of cellular proteins
(Frontiers Media S.A., 2023-03-28)Our recent data established that HIV-1 Nef is pivotal in determining the fate of cellular proteins by modulating ubiquitination. However, it is unknown which proteins are ubiquitinated in the presence of Nef, a question ... -
Sex and strain differences in renal hemodynamics in mice
(Wiley Periodicals, Inc., 2023-03-23)The present study was to examine sex and strain differences in glomerular filtration rate (GFR) and renal blood flow (RBF) in C57BL6, 129/Sv, and C57BLKS/J mice, three commonly used mouse strains in renal research. GFR was ... -
Comparing Short-Term Radiographic Outcomes of Cementless Primary Reverse Total Shoulder Arthroplasty Implantation With and Without Augmentation by Humeral Matchstick Autograft: A Retrospective Cohort Study
(2021-12)Reverse Total Shoulder Arthroplasty (RTSA) is an arthroplasty procedure that is increasing in incidence in the United States (26). As the incidence of the procedure increases, the gross number of RTSA complications is also ... -
Roadblocks in Clinical Research: An Analysis of Common Barriers to the Clinical Research Process
(2022-12)Deficiencies in the clinical research process can lead to delays, loss of funding, outdated conclusions, and a lack in participation for both volunteers and scientists or clinicians. This project aimed to identify the ... -
The Role of LLT1 (CLEC2D, OCIL) in Ewing Sarcoma
(2021-12)Ewing Sarcoma (EWS) is a pediatric bone cancer that is characterized by a chromosomal translocation giving rise to a neomorphic gene fusion. Although treatment of EWS has a 5-year incident free survival rate of 66%, treatment ... -
Transfer function analysis of dynamic cerebral autoregulation: A CARNet white paper 2022 update
(International Society for Cerebral Blood Flow and Metabolism, 2022-08-14)Cerebral autoregulation (CA) refers to the control of cerebral tissue blood flow (CBF) in response to changes in perfusion pressure. Due to the challenges of measuring intracranial pressure, CA is often described as the ... -
Cabazitaxel-Loaded Nanoparticles Reduce the Invasiveness in Metastatic Prostate Cancer Cells: Beyond the Classical Taxane Function
(MDPI, 2023-02-26)Bone-metastatic prostate cancer symbolizes the beginning of the later stages of the disease. We designed a cabazitaxel-loaded, poly (lactic-co-glycolic acid) (PLGA) nanoparticle using an emulsion-diffusion-evaporation ... -
Hyperacute immune responses associate with immediate neuropathology and motor dysfunction in large vessel occlusions
(John Wiley & Sons, Inc., 2022-12-30)OBJECTIVE: Despite successful endovascular therapy, a proportion of stroke patients exhibit long-term functional decline, regardless of the cortical reperfusion. Our objective was to evaluate the early activation of the ... -
Withaferin A: A Pleiotropic Anticancer Agent from the Indian Medicinal Plant Withania somnifera (L.) Dunal
(MDPI, 2023-01-22)Cancer represents the second most deadly disease and one of the most important public health concerns worldwide. Surgery, chemotherapy, radiation therapy, and immune therapy are the major types of treatment strategies that ... -
Nasal Tumor Vaccination Protects against Lung Tumor Development by Induction of Resident Effector and Memory Anti-Tumor Immune Responses
(MDPI, 2023-02-26)Lung metastasis is a leading cause of cancer-related deaths. Here, we show that intranasal delivery of our engineered CpG-coated tumor antigen (Tag)-encapsulated nanoparticles (NPs)-nasal nano-vaccine-significantly reduced ... -
Differential Expression of LLT1, SLAM Receptors CS1 and 2B4 and NCR Receptors NKp46 and NKp30 in Pediatric Acute Lymphoblastic Leukemia (ALL)
(MDPI, 2023-02-26)Acute lymphoblastic leukemia (ALL) represents the most common pediatric cancer. Most patients (85%) develop B-cell ALL; however, T-cell ALL tends to be more aggressive. We have previously identified 2B4 (SLAMF4), CS1 ... -
QEEG Signatures are Associated with Nonmotor Dysfunctions in Parkinson's Disease and Atypical Parkinsonism: An Integrative Analysis
(Aging and Disease, 2023-02-24)Parkinson's disease (PD) and atypical parkinsonism (AP), including progressive supranuclear palsy (PSP) and multiple system atrophy (MSA), share similar nonmotor symptoms. Quantitative electroencephalography (QEEG) can be ... -
A Reliable Nonhuman Primate Model of Ischemic Stroke with Reproducible Infarct Size and Long-term Sensorimotor Deficits
(Aging and Disease, 2023-02-24)A nonhuman primate model of ischemic stroke is considered as an ideal preclinical model to replicate various aspects of human stroke because of their similarity to humans in genetics, neuroanatomy, physiology, and immunology. ... -
Touchscreen-Based Cognitive Training Alters Functional Connectivity Patterns in Aged But Not Young Male Rats
(Society for Neuroscience, 2023-02-09)Age-related cognitive decline is related to cellular and systems-level disruptions across multiple brain regions. Because age-related cellular changes within different structures do not show the same patterns of dysfunction, ... -
Metabolic Heterogeneity of Cerebral Cortical and Cerebellar Astrocytes
(MDPI, 2023-01-22)Astrocytes play critical roles in regulating neuronal synaptogenesis, maintaining blood-brain barrier integrity, and recycling neurotransmitters. Increasing numbers of studies have suggested astrocyte heterogeneity in ... -
Editorial: Renal injury and the brain
(Frontiers Media S.A., 2023-01-24)