School of Biomedical Sciences
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Open Access scholarship from the School of Biomedical Sciences at the University of North Texas Health Science Center at Fort Worth.
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Mutual Independence of Loci in databases of Multi-locus Genotypes: Application in Human Identification and Population Genetics
(2020-12)Multi-locus genotype data are widely used in population genetics and disease studies. In evaluating the utility of multi-locus data, the independence of markers is commonly considered in many genomic assessments. Generally, ... -
Real-World Utilization of Drug X in the Outpatient Setting
(2021-12)Infections caused by multi-drug resistant organisms are on the rise globally and the need for novel antibiotic therapies or new uses for existing antibiotic therapies is higher than ever. This on-going retrospective ... -
Improving Human Identification Using the Human Skin Microbiome
(2021-12)There are times when biological evidence has too low of quality or quantity of human DNA to provide enough information for human identification (HID). However, nucleic acids from the human skin microbiome are sources of ... -
Sexual Dimorphism in Permanent Human Dentition
(2021-05)Sexual dimorphism refers to differences between males and females of the same species. A general pattern of sexual dimorphism is displayed in humans. Across mammalian populations, males generally have a larger body than ... -
The Long-Term Neurodegenerative Effects of Repetitive Mild Traumatic Brain Injury and Treatment With Sigma-1 Receptor Agonist PRE-084
(2021-05)An estimated 1.6 – 3.8 million sports-related traumatic brain injuries (TBI) occur every year in the U.S. Recent retrospective studies suggest that repetitive mild TBI (rmTBI) is associated with the earlier onset of ... -
Intensity of Usual Care Therapeutic Interventions in Inpatient Rehabilitation - A Pilot Study
(2019-12)Minimal evidence exists describing key dosing parameters of interventions used during the subacute phase of recovery after neurological injury. This prospective cohort study aims to assess cardiorespiratory strain resulting ... -
Microbial Natural Product Drug Discovery Through Systematic Sampling of Diverse Texas Soils
(2021-08)This project aimed to explore a new approach to microbial natural product discovery through collection of soil samples from strategically determined geographic sites in the State of Texas. Morphologically distinctive ... -
The Effects of Ad5.CMV.hTGFβ2C226/228S on AHD in Mice
(2021-05)Elevated intraocular pressure (IOP) is a key risk factor for the development of primary open-angle glaucoma (POAG), a leading cause of blindness in people over the age of 40 years. Transforming growth factor beta-2 is a ... -
Providers' Satisfaction with Provision of Prenatal Care During the COVID-19 Pandemic
(2021-05)Pregnant women are among a high-risk patient population for contracting COVID-19, but they still require adequate prenatal care throughout pregnancy to ensure optimal health for both the fetus and mother. Many prenatal ... -
Development and In Vitro Characterization of Gemcitabine Loaded Nanoparticles for Pancreatic Cancer Therapy
(2021-05)Pancreatic Ductal Adenocarcinoma (PDAC) is the 4th leading cause of cancer deaths worldwide and the most common type of pancreatic malignancy (90%). With a poor five-year survival rate of only 5-8%, complete surgical ... -
The Effects of Osteopathic Manipulation Techniques on the Lymphatic System
(2021-05)Osteopathic manipulation techniques (OMT) have been utilized by osteopathic physicians to treat a variety of conditions including musculoskeletal dysfunctions, edema, inflammation, and disease. However, the mechanisms by ... -
The Neuroprotective Effects of SA-2-NP in a Mouse Model of RGC Injury
(2021-05)Determine if a novel hybrid compound SA-2 can be delivered to the retina in a nanoparticle formulation and have protective effects on retinal ganglion cells (RGCs) following an optic nerve crush (ONC) model of RGC death. ... -
Assessing Ecogeographical Variation in the Nasal Passages Utilizing 3D Semilandmarks
(2021-05)Prior research has shown strong statistical relationships between geographically-patterned variation in nasal skeletal morphology and global climatic conditions. Specifically, the nasal skeletons of individuals indigenous ... -
Methods to Reduce Medication Errors and Improve Medication Adherence Among Elderly Patients Facing a Language Barrier
(2021-05)A significant and growing portion of the population of the United States is of limited English proficiency (LEP). In healthcare, LEP patients are a high-risk group for adverse medical events. Elderly patients are also a ... -
In Vitro Methods for Evaluating Anti-Cancer Drugs
(2020-12)Cancer is a major health concern for the world, with children's cancers being particularly devastating. Children's brain cancers are treatable, but those treatments often leave behind developmental impairments and so it ... -
The Role of Mechanosensory TRPV4 Channels and Nitric Oxide Signaling in Intraocular Pressure Homeostasis and its Impairment in Glaucoma
(2020-08)Several population-based studies have identified elevated intraocular pressure (IOP) as a major causative risk factor associated with primary open angle glaucoma (POAG), the most common form of glaucoma that affects millions ... -
Transcriptomic Signatures of Cognitive Impairment
(2020-08)The dramatic shift in population demographics and rapid growth of the aging population has resulted in a drastic increase in the prevalence of complex age-related diseases. Of the most common age-related complex diseases, ... -
Thymic Atrophy Impairs the Development and Function of an Antigen-Specific Treg Clone
(2021-05)Age-related thymic atrophy results in dysfunctional ɑβ-T cell selection, exhibited by reduced output of naïve conventional T (Tcon) cells coupled with a contraction of the T cell receptor (TCR) repertoire. This opens "holes" ... -
The Role of Transforming Growth Factor Beta 2 Signaling and MicroRNAs in Optic Nerve Head Remodeling
(2020-08)Primary open-angle glaucoma (POAG) is a prevalent age-related neurodegenerative disease of the visual system. There are functional and morphological changes in the retina, optic nerve head (ONH) and brain that lead to an ... -
Carisoprodol's Pharmacological Properties at GABAA Receptors, In-vitro and In-silico Studies
(2021-05)Carisoprodol (CSP) is a centrally-acting prescription muscle relaxant that can directly activate, allosterically modulate and inhibit GABAA receptors. The GABAA receptor is a pentameric chloride ion channel in the cys-loop ...