• Endothelin-1 mediated decline in mitochondrial function contributes to neurodegeneration in glaucoma 

  Chaphalkar, Renuka M. (2020-08)

  Glaucoma is an optic neuropathy with multifactorial etiologies, commonly associated with elevated intraocular pressure (IOP) and characterized by degeneration of the optic nerve, loss of retinal ganglion cells (RGC), cupping ...

• Chronic testosterone deprivation sensitizes the middle-aged rat brain to damaging effects of testosterone 

  Smith, Charity (2020-05)

  Levels of the testosterone (T) fall in aging men. Recently, the number of men obtaining testosterone replacement therapy (TRT) has increased dramatically. However, other consequences of aging, such as increased oxidative ...

• The impact of circadian misalignment on health and wellness in medical students 

  Roig, Christopher A. (2020-05)

  Circadian misalignment, or "social jetlag" refers to a mismatch between the internal circadian clock and external timings (e.g. societal timings) and behaviorally manifests as inappropriately timed sleep/wake cycles or ...

• An anatomical study of the pelvic diaphragm 

  Lam, Erik (2019-08)

  The pelvic diaphragm represents a group of muscles located at the pelvic outlet and is involved in pelvic floor dysfunctions. Alternative therapies targeting obturator internus have been suggested in strengthening pelvic ...

• Increased resolution screening of the pharmacogenetic gene CYP2D6 with microarray technology 

  Davis, Carey P. (2019-08)

  Autopsy is a primary methodology used for assessing cause and/or manner of death in medicolegal investigations. Some autopsies, however, do not resolve the cause of death unambiguously or there is no evident pathology to ...

• Validation of HemaSpotTM devices for the collection and long-term, room temperature storage of biological fluids from forensic reference samples 

  Gonzalez, Kimberly A. (2019-05)

  As forensic DNA samples spend more time in storage, collection devices capable of long-term, room temperature preservation provide cost-effective solutions. This project evaluated two different HemaSpot(TM) cartridges for ...

• Impact Of Culture Conditions on Primary Astrocyte Phenotype 

  Prah, Jude K. (2019-05)

  Although previously thought to be passive support cells in the central nervous system (CNS), recent findings introduced critical contributions of astrocytes to numerous CNS functions like energy metabolism, ion and water ...

• Assessment of Oxford Nanopore Technologies as a Sequencing Platform for Increased Taxonomic Resolution of Microbial Communities 

  Valenti, Kiana L. (2019-05)

  Microbiome profiling for forensic identification is an emerging area of research. Profiling the microbiome of trace evidence for forensic cases will become more prevalent as more reliable, accurate, and efficient methodology ...

• Connexin 43 Contributes to Estrogen Protection against Oxidative Stress in Cortical Astrocytes 

  Kubelka, Nicholas K. (2019-05)

  Age-related brain disorders are associated with the decline in the ability of brain cells to cope with homeostatic challenge. Although all major brain cell types have the capacity to respond to homeostatic challenges, ...

• Analysis of HemaSpot[TM]-HF and HemaSpot[TM]-HD Sampling Kits Using Trace DNA 

  McGehee, Rachel L. (2019-05)

  Spot On Sciences, Inc. has recently developed a new device, the HemaSpot[TM], which allows for samples to be stored safely at ambient temperatures. The UNTHSC FGEN program was contacted to conduct a research study to ...

• Sequencing Long Amplicon Microsatellite Loci Using the Oxford Nanopore Technologies MinION[TM] Device 

  Hall, Courtney L. (2019-05)

  Forensic DNA typing utilizes highly variable short tandem repeat (STR) markers to differentiate individuals. Despite the power and reliability of current techniques, sequence-level variations are masked in the length-based ...

• Bioengineered Nanoparticles for Targeted Cancer Therapy 

  Gdowski, Andrew S, (2018-05)

  Despite improved overall survival in cancer patients over the past 50 years, limited advances have been made in treating patients with metastatic cancers. Multiple types of cancers demonstrate the unique ability to ...

• Phenotype of Neurons in the Nucleus Tractus Solitarius Labeled using an Optogenetic Construct with a CaMKIIa Promoter 

  Lopez, Jackson D. (2017-05)

  Optogenetics is a very useful technique used to activate or inhibit specific cells of interest in specific brain regions. The purpose of this study was to determine the phenotype of cells within the nucleus tractus solitarius ...

• Clinical Significance of Annexin A2 in Predicting Poor Prognosis in African American Women with Triple-Negative Breast Cancer 

  Gibbs, Lee D. (2017-05)

  Triple-negative breast cancers (TNBC) are identified by the absence of these three major receptors that drive most breast cancer subtypes. TNBC is the most aggressive breast cancer subtype and studies have shown that the ...

• Pyruvate-enriched Preservation of Machine Perfused Kidneys 

  Omar, Salma K. (2020-05)

  Purpose: Kidney transplantation remains the gold-standard treatment for patients diagnosed with end-stage renal disease (ESRD). However, the demand for donors currently far outpaces the supply. Kidneys donated after cardiac ...

• The Validation of the RapidHIT ID System for Human Identification 

  Campos, Gemma R. (2020-05)

  Forensic scientists routinely employ short tandem repeat (STR) typing as a means to identify or exclude individuals as the donors of biological evidence at crime scenes. Despite developments in automation of STR typing ...

• Alternative procedure for DNA recovery from cartridges and casings 

  Bettex, Kelsey D. (2020-05)

  Both unfired and fired ammunition recovered from a crime scene are useful in connecting a crime to a specific firearm, however its use in identifying individuals is less common due to low-level or degraded DNA present. ...

• Typing Highly Degraded DNA Using Target Enrichment 

  Kieser, Rachel E. (2020-05)

  Forensic genetic profiling is the process of targeting unique positions within the human genome for identity testing of biological DNA evidence. Forensic profiling of highly degraded DNA samples is one of the primary ...

• Validation of the PowerPlex(R) Fusion 6C System and Alternate Robotic Methods on the Hamilton MICROLAB(R) STAR 

  Smith, Briana N. (2020-05)

  Internal validations are done in forensic laboratories to ensure the methods and procedures are working as expected. For this internship practicum, I conducted an internal validation of Promega's PowerPlex(R) Fusion 6C ...

• Optimization and Evaluation of qPCR Duplex Assay for mtDNA Copy Number Quantification 

  Johnson, Gretchen A. (2020-05)

  Purpose: The mitochondrial genome (mtDNA) encodes thirteen essential proteins in oxidative phosphorylation, the cell's primary energy-generating process. Depending on the cell type and stage of development, each cell ...

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