• The regulation of transforming growth factor beta-2-induced ocular hypertension and glaucomatous environment in the trabecular meshwork 

  Roberts, Amanda L. (2020-12)

  Glaucoma is a heterogeneous group of optic neuropathies that damage the optic nerve that leads to progressive visual loss and irreversible blindness in over 80 million people worldwide. Primary open angle glaucoma (POAG) ...

• The SPADE symptom cluster and physical disability in chronic low back pain patients 

  Hendrix, Zachary N. (2019-12)

  Introduction: Chronic pain is a major healthcare issue. It is debilitating and often occurs simultaneously with other health issues (Murray et al., 2013; Shmagel et al., 2016). The SPADE symptom cluster (sleep disturbance, ...

• Retrospective analysis of phase 3 clinical trial to evaluate the efficacy of drug B in anemia secondary to chronic kidney disease 

  Pollard, Kellyn (2019-12)

  To evaluate the hemoglobin (Hb) levels in 18 patients with anemia secondary to chronic kidney disease, the safety and efficacy of Drug B (HIF-PH inhibitor) was compared to the standard of care. The purpose was to assess ...

• Effect of CRISPR MIEN1 knockout in metastatic breast cancer cells 

  Van Treuren, Timothy (2018-12)

  Migration and Invasion Enhancer 1 (MIEN1) is an oncogene which is involved in facilitating the migration and invasion of cancer cells through actin dynamics and gene expression. Increased MIEN1 expression in many types of ...

• Phosphorlyation of Annexin A2 is essential for its association with exosomes and for migration, invasion and proliferation in triple negative breast cancer 

  Desai, Priyanka P. (2018-12)

  Exosomes are membrane enclosed small vesicles that range from 40-120 nm in size and participate in cell-cell communication by transferring proteins to other cells. Annexin A2 (AnxA2), a calcium-dependent phospholipid binding ...

• Brainstem mechanisms that impair autonomic regulation of bloood pressure with obesity 

  Chaudhary, Parul (2018-12)

  Metabolic syndrome (MetS) is emerging as a global health threat due to its strong association with increased risk for cardiovascular disease and diabetes. Currently, 20-25% of the world's population exhibits some traits ...

• Endothelin-1 mediated decline in mitochondrial function contributes to neurodegeneration in glaucoma 

  Chaphalkar, Renuka M. (2020-08)

  Glaucoma is an optic neuropathy with multifactorial etiologies, commonly associated with elevated intraocular pressure (IOP) and characterized by degeneration of the optic nerve, loss of retinal ganglion cells (RGC), cupping ...

• Chronic testosterone deprivation sensitizes the middle-aged rat brain to damaging effects of testosterone 

  Smith, Charity (2020-05)

  Levels of the testosterone (T) fall in aging men. Recently, the number of men obtaining testosterone replacement therapy (TRT) has increased dramatically. However, other consequences of aging, such as increased oxidative ...

• The impact of circadian misalignment on health and wellness in medical students 

  Roig, Christopher A. (2020-05)

  Circadian misalignment, or "social jetlag" refers to a mismatch between the internal circadian clock and external timings (e.g. societal timings) and behaviorally manifests as inappropriately timed sleep/wake cycles or ...

• An anatomical study of the pelvic diaphragm 

  Lam, Erik (2019-08)

  The pelvic diaphragm represents a group of muscles located at the pelvic outlet and is involved in pelvic floor dysfunctions. Alternative therapies targeting obturator internus have been suggested in strengthening pelvic ...

• Increased resolution screening of the pharmacogenetic gene CYP2D6 with microarray technology 

  Davis, Carey P. (2019-08)

  Autopsy is a primary methodology used for assessing cause and/or manner of death in medicolegal investigations. Some autopsies, however, do not resolve the cause of death unambiguously or there is no evident pathology to ...

• Validation of HemaSpotTM devices for the collection and long-term, room temperature storage of biological fluids from forensic reference samples 

  Gonzalez, Kimberly A. (2019-05)

  As forensic DNA samples spend more time in storage, collection devices capable of long-term, room temperature preservation provide cost-effective solutions. This project evaluated two different HemaSpot(TM) cartridges for ...

• Impact Of Culture Conditions on Primary Astrocyte Phenotype 

  Prah, Jude K. (2019-05)

  Although previously thought to be passive support cells in the central nervous system (CNS), recent findings introduced critical contributions of astrocytes to numerous CNS functions like energy metabolism, ion and water ...

• Assessment of Oxford Nanopore Technologies as a Sequencing Platform for Increased Taxonomic Resolution of Microbial Communities 

  Valenti, Kiana L. (2019-05)

  Microbiome profiling for forensic identification is an emerging area of research. Profiling the microbiome of trace evidence for forensic cases will become more prevalent as more reliable, accurate, and efficient methodology ...

• Connexin 43 Contributes to Estrogen Protection against Oxidative Stress in Cortical Astrocytes 

  Kubelka, Nicholas K. (2019-05)

  Age-related brain disorders are associated with the decline in the ability of brain cells to cope with homeostatic challenge. Although all major brain cell types have the capacity to respond to homeostatic challenges, ...

• Analysis of HemaSpot[TM]-HF and HemaSpot[TM]-HD Sampling Kits Using Trace DNA 

  McGehee, Rachel L. (2019-05)

  Spot On Sciences, Inc. has recently developed a new device, the HemaSpot[TM], which allows for samples to be stored safely at ambient temperatures. The UNTHSC FGEN program was contacted to conduct a research study to ...

• Sequencing Long Amplicon Microsatellite Loci Using the Oxford Nanopore Technologies MinION[TM] Device 

  Hall, Courtney L. (2019-05)

  Forensic DNA typing utilizes highly variable short tandem repeat (STR) markers to differentiate individuals. Despite the power and reliability of current techniques, sequence-level variations are masked in the length-based ...

• Bioengineered Nanoparticles for Targeted Cancer Therapy 

  Gdowski, Andrew S, (2018-05)

  Despite improved overall survival in cancer patients over the past 50 years, limited advances have been made in treating patients with metastatic cancers. Multiple types of cancers demonstrate the unique ability to ...

• Phenotype of Neurons in the Nucleus Tractus Solitarius Labeled using an Optogenetic Construct with a CaMKIIa Promoter 

  Lopez, Jackson D. (2017-05)

  Optogenetics is a very useful technique used to activate or inhibit specific cells of interest in specific brain regions. The purpose of this study was to determine the phenotype of cells within the nucleus tractus solitarius ...

• Clinical Significance of Annexin A2 in Predicting Poor Prognosis in African American Women with Triple-Negative Breast Cancer 

  Gibbs, Lee D. (2017-05)

  Triple-negative breast cancers (TNBC) are identified by the absence of these three major receptors that drive most breast cancer subtypes. TNBC is the most aggressive breast cancer subtype and studies have shown that the ...

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