Now showing items 1-11 of 11

    • A Precision Medicine Approach to Treating Alzheimer's Disease Using Rosiglitazone Therapy: A Biomarker Analysis of the REFLECT Trials 

      O'Bryant, Sid E.; Zhang, Fan; Petersen, Melissa E.; Johnson, Leigh A.; Hall, James R.; Rissman, Robert A.; 0000-0003-0582-5266 (O'Bryant, Sid E.); 0000-0001-7769-8417 (Johnson, Leigh A.); 0000-0002-3920-5877 (Petersen, Melissa E.) (IOS Press, 2021-05-18)
      Background: The REFLECT trials were conducted to examine the treatment of mild-to-moderate Alzheimer's disease utilizing a peroxisome proliferator-activated receptor gamma agonist. Objective: To generate a predictive ...
    • A proteomic signature for dementia with Lewy bodies 

      O'Bryant, Sid E.; Ferman, Tanis J.; Zhang, Fan; Hall, James R.; Pedraza, Otto; Wszolek, Zbigniew K.; Como, Tori; Julovich, David A.; Mattevada, Sravan; Johnson, Leigh A.; Edwards, Melissa; Graff-Radford, Neill R.; 0000-0003-0582-5266 (O'Bryant, Sid E.); 0000-0001-7769-8417 (Johnson, Leigh A.) (Elsevier Inc., 2019-03-15)
      Introduction: We sought to determine if a proteomic profile approach developed to detect Alzheimer's disease would distinguish patients with Lewy body disease from normal controls, and if it would distinguish dementia with ...
    • Accelerating Hyperparameter Tuning in Machine Learning for Alzheimer's Disease With High Performance Computing 

      Zhang, Fan; Petersen, Melissa E.; Johnson, Leigh A.; Hall, James R.; O'Bryant, Sid E.; 0000-0003-0582-5266 (O'Bryant, Sid E.); 0000-0001-7769-8417 (Johnson, Leigh A.); 0000-0002-3920-5877 (Petersen, Melissa E.) (Frontiers Media S.A., 2021-12-08)
      Driven by massive datasets that comprise biomarkers from both blood and magnetic resonance imaging (MRI), the need for advanced learning algorithms and accelerator architectures, such as GPUs and FPGAs has increased. Machine ...
    • Identification of long non-coding RNA-related and -coexpressed mRNA biomarkers for hepatocellular carcinoma 

      Zhang, Fan; Ding, Linda; Cui, Li; Barber, Robert C.; Deng, Bin; 0000-0001-6857-0286 (Barber, Robert C.) (BioMed Central Ltd., 2019-01-31)
      Background: While changes in mRNA expression during tumorigenesis have been used widely as molecular biomarkers for the diagnosis of a number of cancers, the approach has limitations. For example, traditional methods do ...
    • Identification of novel alternative splicing biomarkers for breast cancer with LC/MS/MS and RNA-Seq 

      Zhang, Fan; Deng, Chris K.; Wang, Mu; Deng, Bin; Barber, Robert C.; Huang, Gang; 0000-0001-6857-0286 (Barber, Robert C.) (BioMed Central Ltd., 2020-12-03)
      Background: Alternative splicing isoforms have been reported as a new and robust class of diagnostic biomarkers. Over 95% of human genes are estimated to be alternatively spliced as a powerful means of producing functionally ...
    • Neurodegeneration from the AT(N) framework is different among Mexican Americans compared to non-Hispanic Whites: A Health & Aging Brain among Latino Elders (HABLE) Study 

      O'Bryant, Sid E.; Zhang, Fan; Petersen, Melissa E.; Hall, James R.; Johnson, Leigh A.; Yaffe, Kristine; Braskie, Meredith N.; Rissman, Robert A.; Vig, Rocky; Toga, Arthur W.; 0000-0003-0582-5266 (O'Bryant, Sid E.); 0000-0001-7769-8417 (Johnson, Leigh A.); 0000-0002-3920-5877 (Petersen, Melissa E.) (Wiley Periodicals, LLC, 2022-02-09)
      Introduction: We sought to examine a magnetic resonance imaging (MRI)-based marker of neurodegeneration from the AT(N) (amyloid/tau/neurodegeneration) framework among a multi-ethnic, community-dwelling cohort. Methods: ...
    • Potential two-step proteomic signature for Parkinson's disease: Pilot analysis in the Harvard Biomarkers Study 

      O'Bryant, Sid E.; Edwards, Melissa; Zhang, Fan; Johnson, Leigh A.; Hall, James R.; Kuras, Yuliya; Scherzer, Clemens R.; 0000-0003-0582-5266 (O'Bryant, Sid E.); 0000-0001-7769-8417 (Johnson, Leigh A.) (Elsevier Inc., 2019-05-02)
      Introduction: We sought to determine if our previously validated proteomic profile for detecting Alzheimer's disease would detect Parkinson's disease (PD) and distinguish PD from other neurodegenerative diseases. Methods: ...
    • Proteomic profiles for Alzheimer's disease and mild cognitive impairment among adults with Down syndrome spanning serum and plasma: An Alzheimer's Biomarker Consortium-Down Syndrome (ABC-DS) study 

      Petersen, Melissa E.; Zhang, Fan; Schupf, Nicole; Krinsky-McHale, Sharon J.; Hall, James R.; Mapstone, Mark; Cheema, Amrita; Silverman, Wayne; Lott, Ira; Rafii, Michael S.; Handen, Benjamin; Klunk, William; Head, Elizabeth; Christian, Bradley; Foroud, Tatiana; Lai, Florence; Rosas, H. Diana; Zaman, Shahid; Ances, Beau M.; Wang, Mei-Cheng; Tycko, Benjamin; Lee, Joseph H.; O'Bryant, Sid E.; 0000-0003-0582-5266 (O'Bryant, Sid E.); 0000-0002-3920-5877 (Petersen, Melissa E.) (Wiley Periodicals, Inc., 2020-06-30)
      Introduction: Previously generated serum and plasma proteomic profiles were examined among adults with Down syndrome (DS) to determine whether these profiles could discriminate those with mild cognitive impairment (MCI-DS) ...
    • Proteomic profiles of incident mild cognitive impairment and Alzheimer's disease among adults with Down syndrome 

      O'Bryant, Sid E.; Zhang, Fan; Silverman, Wayne; Lee, Joseph H.; Krinsky-McHale, Sharon J.; Pang, Deborah; Hall, James R.; Schupf, Nicole; 0000-0003-0582-5266 (O'Bryant, Sid E.) (Wiley Periodicals, Inc., 2020-05-21)
      Introduction: We sought to determine if proteomic profiles could predict risk for incident mild cognitive impairment (MCI) and Alzheimer's disease (AD) among adults with Down syndrome (DS). Methods: In a cohort of 398 ...
    • Proteomic profiles of prevalent mild cognitive impairment and Alzheimer's disease among adults with Down syndrome 

      Petersen, Melissa E.; Zhang, Fan; Krinsky-McHale, Sharon J.; Silverman, Wayne; Lee, Joseph H.; Pang, Deborah; Hall, James R.; Schupf, Nicole; O'Bryant, Sid E.; 0000-0003-0582-5266 (O'Bryant, Sid E.); 0000-0002-3920-5877 (Petersen, Melissa E.) (Wiley Periodicals, Inc., 2020-04-17)
      Introduction: We sought to determine if a proteomic profile approach developed to detect Alzheimer's disease (AD) in the general population would apply to adults with Down syndrome (DS). Methods: Plasma samples were ...
    • The Health & Aging Brain among Latino Elders (HABLE) study methods and participant characteristics 

      O'Bryant, Sid E.; Johnson, Leigh A.; Barber, Robert C.; Braskie, Meredith N.; Christian, Bradley; Hall, James R.; Hazra, Nalini; King, Kevin; Kothapalli, Deydeep; Large, Stephanie; Mason, David; Matsiyevskiy, Elizabeth; McColl, Roderick; Nandy, Rajesh; Palmer, Raymond; Petersen, Melissa E.; Philips, Nicole; Rissman, Robert A.; Shi, Yonggang; Toga, Arthur W.; Vintimilla, Raul; Vig, Rocky; Zhang, Fan; Yaffe, Kristine; 0000-0001-6857-0286 (Barber, Robert C.); 0000-0003-0582-5266 O'Bryant, Sid E.; 0000-0001-7769-8417 (Johnson, Leigh A.); 0000-0002-3920-5877 (Petersen, Melissa E.) (Wiley Periodicals, LLC, 2021-06-21)
      Introduction: Mexican Americans remain severely underrepresented in Alzheimer's disease (AD) research. The Health & Aging Brain among Latino Elders (HABLE) study was created to fill important gaps in the existing literature. ...