Now showing items 1-8 of 8

    • Aging Systemic Milieu Impairs Outcome after Ischemic Stroke in Rats 

      Pan, Mengxiong; Wang, Peng; Zheng, Chengcai; Zhang, Hongxia; Lin, Siyang; Shao, Bei; Zhuge, Qichuan; Jin, Kunlin; 0000-0002-1336-348X (Jin, Kunlin) (JKL International, 2017-10-01)
      Compelling evidence indicates that factors in the blood can profoundly reverse aging-related impairments, as exposure of aged mice to young blood rejuvenates adult stem cell function, improves cognition, and ameliorates ...
    • AMPK Signaling Regulates the Age-Related Decline of Hippocampal Neurogenesis 

      Wang, Brian Z.; Yang, Jane J.; Zhang, Hongxia; Smith, Charity A.; Jin, Kunlin; 0000-0002-1336-348X (Jin, Kunlin) (JKL International, 2019-10-01)
      The global incidence of age-associated neurological diseases is expected to rise with increasingly greying societies. In the aged brain, there is a dramatic decrease in the number of stem cells, which is a main cause for ...
    • Blood Inflammatory Exosomes with Age Prime Microglia through Complement Signaling for Negative Stroke Outcomes 

      Zhang, Hongxia; 0000-0003-1594-6707 (2020-05)
      The systemic inflammatory milieu plays an important role in the age-related decline of functional integrity, but its contribution to age-related disease (e.g., stroke) remains largely unknown. Here, we found that activated ...
    • Combining Injectable Plasma Scaffold with Mesenchymal Stem/Stromal Cells for Repairing Infarct Cavity after Ischemic Stroke 

      Zhang, Hongxia; Sun, Fen; Wang, Jixian; Xie, Luokun; Yang, Chenqi; Pan, Mengxiong; Shao, Bei; Yang, Guo-Yuan; Yang, Shao-Hua; Zhuge, Qichuan; Jin, Kunlin; 0000-0002-1336-348X (Jin, Kunlin); 0000-0002-0405-0887 (Yang, Shaohua) (JKL International, 2017-04-01)
      Stroke survivors are typically left with structural brain damage and associated functional impairment in the chronic phase of injury, for which few therapeutic options exist. We reported previously that transplantation of ...
    • Key Signaling Pathways in Aging and Potential Interventions for Healthy Aging 

      Yu, Mengdi; Zhang, Hongxia; Wang, Brian; Zhang, Yinuo; Zheng, Xiaoying; Shao, Bei; Zhuge, Qichuan; Jin, Kunlin; 0000-0002-1336-348X (Jin, Kunlin) (MDPI, 2021-03-16)
      Aging is a fundamental biological process accompanied by a general decline in tissue function. Indeed, as the lifespan increases, age-related dysfunction, such as cognitive impairment or dementia, will become a growing ...
    • Peripheral Circulating Exosomal miRNAs Potentially Contribute to the Regulation of Molecular Signaling Networks in Aging 

      Zhang, Hongxia; Jin, Kunlin; 0000-0002-1336-348X (Jin, Kunlin) (MDPI, 2020-03-11)
      People are living longer than ever. Consequently, they have a greater chance for developing a functional impairment or aging-related disease, such as a neurodegenerative disease, later in life. Thus, it is important to ...
    • SDF-1/CXCR7 Chemokine Signaling is Induced in the Peri-Infarct Regions in Patients with Ischemic Stroke 

      Zhang, Yu; Zhang, Hongxia; Lin, Siyang; Chen, Xudong; Yao, Yu; Mao, XiaoOu; Shao, Bei; Zhuge, Qichuan; Jin, Kunlin; 0000-0002-1336-348X (Jin, Kunlin) (JKL International, 2018-04-01)
      Stromal-derived factor-1 (SDF-1, also known as CXCL12) and its receptors CXCR4 and CXCR7 play important roles in brain repair after ischemic stroke, as SDF-1/ CXCR4/CXCR7 chemokine signaling is critical for recruiting stem ...
    • The Prognostic Value of Serum Cytokines in Patients with Acute Ischemic Stroke 

      Li, Xianmei; Lin, Siyang; Chen, Xiaoli; Huang, Wensi; Li, Qian; Zhang, Hongxia; Chen, Xudong; Yang, Shaohua; Jin, Kunlin; Shao, Bei; 0000-0002-1336-348X (Jin, Kunlin); 0000-0002-0405-0887 (Yang, Shaohua) (JKL International, 2019-06-01)
      The inflammatory response is an unavoidable process and contributes to the destruction of cerebral tissue during the acute ischemic stroke (AIS) phase and has not been addressed fully to date. Insightful understanding of ...