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Gait Analyses in Mice: Effects of Age and Glutathione Deficiency
(International Society on Aging and Disease, 2018-08-01)
Minor changes (~0.1 m/s) in human gait speed are predictive of various measures of decline and can be used to identify at-risk individuals prior to further decline. These associations are possible due to an abundance of ...
Novel pharmacotherapy: NNI-362, an allosteric p70S6 kinase stimulator, reverses cognitive and neural regenerative deficits in models of aging and disease
(BioMed Central Ltd., 2021-01-13)
Aging is known to slow the neurogenic capacity of the hippocampus, one of only two mammalian adult neurogenic niches. The reduction of adult-born neurons with age may initiate cognitive decline progression which is exacerbated ...
Pancreatic mitochondrial complex I exhibits aberrant hyperactivity in diabetes
(Elsevier Inc., 2017-07-19)
It is well established that NADH/NAD(+) redox balance is heavily perturbed in diabetes, and the NADH/NAD(+) redox imbalance is a major source of oxidative stress in diabetic tissues. In mitochondria, complex I is the only ...