Search
Now showing items 1-9 of 9
Proteomic profiles of prevalent mild cognitive impairment and Alzheimer's disease among adults with Down syndrome
(Wiley Periodicals, Inc., 2020-04-17)
Introduction: We sought to determine if a proteomic profile approach developed to detect Alzheimer's disease (AD) in the general population would apply to adults with Down syndrome (DS). Methods: Plasma samples were ...
Proteomic profiles for Alzheimer's disease and mild cognitive impairment among adults with Down syndrome spanning serum and plasma: An Alzheimer's Biomarker Consortium-Down Syndrome (ABC-DS) study
(Wiley Periodicals, Inc., 2020-06-30)
Introduction: Previously generated serum and plasma proteomic profiles were examined among adults with Down syndrome (DS) to determine whether these profiles could discriminate those with mild cognitive impairment (MCI-DS) ...
Accelerating Hyperparameter Tuning in Machine Learning for Alzheimer's Disease With High Performance Computing
(Frontiers Media S.A., 2021-12-08)
Driven by massive datasets that comprise biomarkers from both blood and magnetic resonance imaging (MRI), the need for advanced learning algorithms and accelerator architectures, such as GPUs and FPGAs has increased. Machine ...
Characterization of the Meal-Stimulated Incretin Response and Relationship With Structural Brain Outcomes in Aging and Alzheimer's Disease
(Frontiers Media S.A., 2020-11-30)
Background: Individuals with Alzheimer's Disease (AD) are often characterized by systemic markers of insulin resistance; however, the broader effects of AD on other relevant metabolic hormones, such as incretins that affect ...
Neurodegeneration from the AT(N) framework is different among Mexican Americans compared to non-Hispanic Whites: A Health & Aging Brain among Latino Elders (HABLE) Study
(Wiley Periodicals, LLC, 2022-02-09)
Introduction: We sought to examine a magnetic resonance imaging (MRI)-based marker of neurodegeneration from the AT(N) (amyloid/tau/neurodegeneration) framework among a multi-ethnic, community-dwelling cohort. Methods: ...
Acute Regression in Down Syndrome
(MDPI, 2021-08-23)
Acute regression has been reported in some individuals with Down syndrome (DS), typically occurring between the teenage years and mid to late 20s. Characterized by sudden, and often unexplained, reductions in language ...
A Precision Medicine Approach to Treating Alzheimer's Disease Using Rosiglitazone Therapy: A Biomarker Analysis of the REFLECT Trials
(IOS Press, 2021-05-18)
Background: The REFLECT trials were conducted to examine the treatment of mild-to-moderate Alzheimer's disease utilizing a peroxisome proliferator-activated receptor gamma agonist. Objective: To generate a predictive ...
Plasma Total Tau and Neurobehavioral Symptoms of Cognitive Decline in Cognitively Normal Older Adults
(Frontiers Media S.A., 2021-11-05)
Depression and related neurobehavioral symptoms are common features of Alzheimer's disease and other dementias. The presence of these potentially modifiable neurobehavioral symptoms in cognitively intact older adults may ...
The Health & Aging Brain among Latino Elders (HABLE) study methods and participant characteristics
(Wiley Periodicals, LLC, 2021-06-21)
Introduction: Mexican Americans remain severely underrepresented in Alzheimer's disease (AD) research. The Health & Aging Brain among Latino Elders (HABLE) study was created to fill important gaps in the existing literature. ...