Now showing items 1-6 of 6
The Role of Angiotensin Converting Enzyme 1 within the Median Preoptic Nucleus Following Chronic Intermittent Hypoxia
These experiments focused on the importance of the brain renin-angiotensin system (RAS) in hypertension caused by a chronic intermittent hypoxia (CIH) model of the hypoxemia associated with sleep apnea. In the CIH model, ...
In vitro and in vivo neuroprotective effects of cJun N-terminal kinase inhibitors on retinal ganglion cells
(BioMed Central Ltd., 2016-04-21)
BACKGROUND: The c-Jun N-terminal kinase (JNK) signaling pathway plays an important role in neuronal pathophysiology. Using JNK inhibitors, we examined involvement of the JNK pathway in cultured rat retinal ganglion cell ...
C1q propagates microglial activation and neurodegeneration in the visual axis following retinal ischemia/reperfusion injury
(BioMed Central Ltd., 2016-03-24)
BACKGROUND: C1q represents the initiating protein of the classical complement cascade, however recent findings indicate pathway independent roles such as developmental pruning of retinal ganglion cell (RGC) axons. Furthermore, ...
Treatment with an orally bioavailable prodrug of 17beta-estradiol alleviates hot flushes without hormonal effects in the periphery
(Springer Nature, 2016-08-01)
Estrogen deprivation has a profound effect on the female brain. One of the most obvious examples of this condition is hot flushes. Although estrogens relieve these typical climacteric symptoms, many women do not want to ...
Expression of Mutant Myocilin Induces Abnormal Intracellular Accumulation of Selected Extracellular Matrix Proteins in the Trabecular Meshwork
(Association for Research in Vision and Ophthalmology, 2016-11-01)
PURPOSE: Abnormal accumulation of extracellular matrix (ECM) in the trabecular meshwork (TM) is associated with decreased aqueous humor outflow facility and IOP elevation in POAG. Previously, we have developed a transgenic ...
HDAC Inhibitor-Mediated Epigenetic Regulation of Glaucoma-Associated TGFbeta2 in the Trabecular Meshwork
(ARVO Journals, 2016-07-01)
PURPOSE: Elevated intraocular pressure (IOP) in primary open-angle glaucoma (POAG) results from glaucomatous damage to the trabecular meshwork (TM). The glaucoma-associated factor TGFbeta2 is increased in aqueous humor and ...