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C1q propagates microglial activation and neurodegeneration in the visual axis following retinal ischemia/reperfusion injury
(BioMed Central Ltd., 2016-03-24)
BACKGROUND: C1q represents the initiating protein of the classical complement cascade, however recent findings indicate pathway independent roles such as developmental pruning of retinal ganglion cell (RGC) axons. Furthermore, ...
Expression of Mutant Myocilin Induces Abnormal Intracellular Accumulation of Selected Extracellular Matrix Proteins in the Trabecular Meshwork
(Association for Research in Vision and Ophthalmology, 2016-11-01)
PURPOSE: Abnormal accumulation of extracellular matrix (ECM) in the trabecular meshwork (TM) is associated with decreased aqueous humor outflow facility and IOP elevation in POAG. Previously, we have developed a transgenic ...