Search
Now showing items 1-10 of 68
Implementation of an unconscious bias course for the National Research Mentoring Network
(BioMed Central Ltd., 2022-05-21)
Purpose: Increased awareness and mitigation of one's unconscious bias is a critical strategy in diversifying the Science, Technology, Engineering, Mathematics, and Medicine (STEMM) disciplines and workforce. Greater ...
Depression, inflammation, and memory loss among Mexican Americans: analysis of the HABLE cohort
(Cambridge University Press, 2017-06-20)
Background: This study explored the combined impact of depression and inflammation on memory functioning among Mexican-American adults and elders. Methods: Data were analyzed from 381 participants of the Health and Aging ...
Current state of Alzheimer's fluid biomarkers
(Springer, 2018-11-28)
Alzheimer's disease (AD) is a progressive neurodegenerative disease with a complex and heterogeneous pathophysiology. The number of people living with AD is predicted to increase; however, there are no disease-modifying ...
Identification of novel alternative splicing biomarkers for breast cancer with LC/MS/MS and RNA-Seq
(BioMed Central Ltd., 2020-12-03)
Background: Alternative splicing isoforms have been reported as a new and robust class of diagnostic biomarkers. Over 95% of human genes are estimated to be alternatively spliced as a powerful means of producing functionally ...
Identification of long non-coding RNA-related and -coexpressed mRNA biomarkers for hepatocellular carcinoma
(BioMed Central Ltd., 2019-01-31)
Background: While changes in mRNA expression during tumorigenesis have been used widely as molecular biomarkers for the diagnosis of a number of cancers, the approach has limitations. For example, traditional methods do ...
Macrophages Modulate the Function of MSC- and iPSC-Derived Fibroblasts in the Presence of Polyethylene Particles
(MDPI, 2021-11-27)
Fibroblasts in the synovial membrane secrete molecules essential to forming the extracellular matrix (ECM) and supporting joint homeostasis. While evidence suggests that fibroblasts contribute to the response to joint ...
Cystatin C as a potential therapeutic mediator against Parkinson's disease via VEGF-induced angiogenesis and enhanced neuronal autophagy in neurovascular units
(Springer Nature, 2017-06-01)
Cystatin C (CYS C, Cst3) is an endogenous cysteine protease inhibitor that plays neuroprotective roles in neurodegenerative diseases. We aimed to explore the association of CYS C with Parkinson's disease (PD) models and ...
A feed-forward regulation of endothelin receptors by c-Jun in human non-pigmented ciliary epithelial cells and retinal ganglion cells
(PLOS, 2017-09-22)
c-Jun, c-Jun N-terminal kinase(JNK) and endothelin B (ETB) receptor have been shown to contribute to the pathogenesis of glaucoma. Previously, we reported that an increase of c-Jun and CCAAT/enhancer binding protein beta ...
Is there a Neurobiological Rationale for the Utility of the Iowa Gambling Task in Parkinson's Disease?
(IOS Press, 2021-04-13)
Up to 23% of newly diagnosed, non-demented, Parkinson's disease (PD) patients experience deficits in executive functioning (EF). In fact, EF deficits may occur up to 39-months prior to the onset of motor decline. Optimal ...
Roles of disease severity and post-discharge outpatient visits as predictors of hospital readmissions
(BioMed Central Ltd., 2016-10-10)
BACKGROUND: Risks prediction models of 30-day all-cause hospital readmissions are multi-factorial. Severity of illness (SOI) and risk of mortality (ROM) categorized by All Patient Refined Diagnosis Related Groups (APR-DRG) ...