Now showing items 1-3 of 3
Psalmotoxin-1 and nonproton ligand interactions with acid-sensing ion channels
Acid-sensing ion channels (ASICs) are trimeric, sodium-selective channels activated by extracellular protons. Although ASICs are intriguing molecular targets for pharmacological agents, there remains a lack of selective ...
The Role of Glycogen Synthase Kinase-3β in the Regulation of Mitochondrial Membrane Permeability
Lens epithelial cells in a fully mature lens thrive in a hypoxic environment by developing several pro-survival mechanisms that can prevent cellular dysfunction. Many of these mechanisms focus on maintaining mitochondrial ...
Intravenous pyruvate to protect heart and brain during closed-chest resuscitation and recovery from cardiac arrest
Cardiac arrest is a leading cause of death in the United States and Western Europe. Cardiopulmonary resuscitation (CPR) is the only means of sustaining the victim until application of defibrillatory countershocks. Although ...