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“Ecstasy” to Addiction: Mechanistic and Reinforcing Effects of Synthetic Cathinone Analogs of MDMA
(2017-05-01)
Following widespread scheduling, many synthetic cathinone compounds have been diverted from “bath salts” to “Ecstasy” tablets or “Molly” powder formulations in addition to or in lieu of 3,4-methylenedioxymethamphetamine ...
Trace amine associated receptor 1 (TAAR1), a novel astrocyte receptor for METH-mediated neurotoxicity in HIV-1-associated neurocognitive disorders (HAND)
(2015-05-01)
This dissertation explores the role of astrocyte trace amine associated receptor 1 (TAAR1), a novel G-protein coupled receptor (GPCR), in modulating the effects of methamphetamine (METH) on astrocyte-mediated excitotoxicity, ...
Intravenous Pyruvate to Prevent Renal Injury Following Cardiac Arrest and Resuscitation
(2014-08-01)
Introduction: Cardiac arrest followed by resuscitation and recovery of spontaneous circulation (ROSC) produces systemic ischemia reperfusion (I/R), affecting all internal organs, including the kidney. This type of stress ...
Psalmotoxin-1 and nonproton ligand interactions with acid-sensing ion channels
(2015-05-01)
Acid-sensing ion channels (ASICs) are trimeric, sodium-selective channels activated by extracellular protons. Although ASICs are intriguing molecular targets for pharmacological agents, there remains a lack of selective ...
The Role of Glycogen Synthase Kinase-3β in the Regulation of Mitochondrial Membrane Permeability
(2014-12-01)
Lens epithelial cells in a fully mature lens thrive in a hypoxic environment by developing several pro-survival mechanisms that can prevent cellular dysfunction. Many of these mechanisms focus on maintaining mitochondrial ...
Statins and PCSK9 Inhibitors: How They Have Shaped Medicine, A Comparative Review
(2016-12-01)
Keeping serum low density lipoprotein cholesterol (LDL-C) levels within recommended ranges has been proven to lower the risk of cardiovascular events from occurring. To lower LDL-C levels, statins have been the drug of ...
Intermittent hypoxia induced opioidergic protection of the heart
(2015-08-01)
Normobaric intermittent hypoxia conditioning (IHC) induces a robust cardioprotected phenotype in dogs that is remarkably resistant to ischemia and reperfusion induced myocardial infarction and lethal arrhythmias. Previous ...
Neuroprotective Effects of Brn3b in PC12 Cells and Retinal Ganglion Cells under Glaucomatous Conditions
(2015-08-01)
Glaucoma is a group of chronic progressive optic neuropathies commonly characterized by elevated intraocular pressure (IOP) (a subset of glaucoma patients display neurodegenerative effects at ‘normal’ IOP) leading to axonal ...
Intravenous pyruvate to protect heart and brain during closed-chest resuscitation and recovery from cardiac arrest
(2014-08-01)
Cardiac arrest is a leading cause of death in the United States and Western Europe. Cardiopulmonary resuscitation (CPR) is the only means of sustaining the victim until application of defibrillatory countershocks. Although ...
Antioxidants, Exercise, APOE Genotype and Brain Function
(2014-12-01)
Apolipoprotein E4 (APOE4) is a well-established and extensively prevalent genetic risk factor for the development of Alzheimer’s disease (AD). The presence of APOE4 allele accelerates the pathophysiology and symptomology ...