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The Effects of Lifelong Glutathione Deficiency on Functional Decline and Redox Signaling
Purpose: A recent paradigm shift has implicated redox state as a potential key determinant underlying the aging process. Specifically, a pro-oxidizing shift in the ratio of reduced to oxidized glutathione (key substrate ...
AMP-Activated Protein Kinase (AMPK) signaling regulates the age-related decline of hippocampal neurogenesis
Aging is the progressive decline of physiological function and increased vulnerability to disease and death. By the year 2050, 2 billion people will be over the age of 60. Accompanying this, the incidence of age-associated ...