Now showing items 14-32 of 32

    • FTD-PSP is an Unusual Clinical Phenotype in A Frontotemporal Dementia Patient with A Novel Progranulin Mutation 

      Deng, Bin; Zheng, Zhe; Zheng, Jialing; Yang, Wanlin; Huang, Yu; Luo, Yuqi; Jin, Dana; Shen, Lu; Jin, Kunlin; Wang, Qing; 0000-0002-1336-348X (Jin, Kunlin) (JKL International, 2021-10-01)
      Progranulin (GRN) mutations are a major cause of frontotemporal dementia (FTD); the spectrum of clinical phenotypes of FTD is much more extensive than previously reported. The frequency and locations of GRN mutations in ...
    • Further validation of the efficacy of mesenchymal stem cell infusions for reducing mortality in COVID-19 patients with ARDS 

      Shetty, Ashok K.; Shetty, Padmashri A.; Zanirati, Gabriele; Jin, Kunlin; 0000-0002-1336-348X (Jin, Kunlin) (Springer Nature, 2021-09-09)
      Recent double-blind, randomized, controlled trials reported that human umbilical cord-derived mesenchymal stem cell (MSC) infusions in COVID-19 patients with acute respiratory distress syndrome (ARDS) could diminish cytokine ...
    • Hypoxia, hibernation and Neuroprotection: An Experimental Study in Mice 

      Ren, Changhong; Li, Sijie; Rajah, Gary; Shao, Guo; Lu, Guowei; Han, Rongrong; Huang, Qingjian; Li, Haiyan; Ding, Yuchuan; Jin, Kunlin; Ji, Xunming; 0000-0002-1336-348X (Jin, Kunlin) (JKL International, 2018-08-01)
      Hibernation is a unique physiological state that evolved to survive periods of food shortages. It is characterized by profound decreases in metabolic rate, body temperature and physiological functions. Studies have shown ...
    • Interdisciplinary Research in Alzheimer's Disease and the Roles International Societies Can Play 

      Tan, Shawn Zheng Kai; Zhao, Robert Chunhua; Chakrabarti, Sasanka; Stambler, Ilia; Jin, Kunlin; Lim, Lee Wei; 0000-0002-1336-348X (Jin, Kunlin) (JKL International, 2021-02-01)
      An ever-increasing ageing population has elevated Alzheimer's disease to be one of the biggest challenges in modern medicine. Alzheimer's disease is highly complex, and we are still no closer to understanding the causes, ...
    • Key Signaling Pathways in Aging and Potential Interventions for Healthy Aging 

      Yu, Mengdi; Zhang, Hongxia; Wang, Brian; Zhang, Yinuo; Zheng, Xiaoying; Shao, Bei; Zhuge, Qichuan; Jin, Kunlin; 0000-0002-1336-348X (Jin, Kunlin) (MDPI, 2021-03-16)
      Aging is a fundamental biological process accompanied by a general decline in tissue function. Indeed, as the lifespan increases, age-related dysfunction, such as cognitive impairment or dementia, will become a growing ...
    • Limb Ischemic Conditioning Improved Cognitive Deficits via eNOS-Dependent Augmentation of Angiogenesis after Chronic Cerebral Hypoperfusion in Rats 

      Ren, Changhong; Li, Ning; Li, Sijie; Han, Rongrong; Huang, Qingjian; Hu, Jiangnan; Jin, Kunlin; Ji, Xunming; 0000-0002-1336-348X (Jin, Kunlin) (JKL International, 2018-10-01)
      Intracranial and extracranial arterial stenosis, the primary cause of chronic cerebral hypoperfusion (CCH), is a critical reason for the pathogenesis of vascular dementia and Alzheimer's disease characterized by cognitive ...
    • Metformin, Rapamycin, or Nicotinamide Mononucleotide Pretreatment Attenuate Cognitive Impairment After Cerebral Hypoperfusion by Inhibiting Microglial Phagocytosis 

      Yu, Mengdi; Zheng, Xiaoying; Cheng, Fangyu; Shao, Bei; Zhuge, Qichuan; Jin, Kunlin; 0000-0002-1336-348X (Jin, Kunlin) (Frontiers Media S.A., 2022-06-13)
      Vascular cognitive impairment (VCI) is the second leading form of dementia after Alzheimer's disease (AD) plaguing the elder population. Despite the enormous prevalence of VCI, the biological basis of this disease has been ...
    • Microglia exacerbate white matter injury via complement C3/C3aR pathway after hypoperfusion 

      Zhang, Lin-Yuan; Pan, Jiaji; Mamtilahun, Muyassar; Zhu, Yuan; Wang, Liping; Venkatesh, Ashwin; Shi, Rubing; Tu, Xuanqiang; Jin, Kunlin; Wang, Yongting; Zhang, Zhijun; Yang, Guo-Yuan; 0000-0002-1336-348X (Jin, Kunlin) (Ivyspring International Publisher, 2020-01-01)
      Microglial activation participates in white matter injury after cerebral hypoperfusion. However, the underlying mechanism is unclear. Here, we explore whether activated microglia aggravate white matter injury via complement ...
    • Nur77 exacerbates PC12 cellular injury in vitro by aggravating mitochondrial impairment and endoplasmic reticulum stress 

      Gao, Huimin; Chen, Zhaoyu; Fu, Yongmei; Yang, Xiaoyan; Weng, Ruihui; Wang, Rui; Lu, Jianjun; Pan, Mengqiu; Jin, Kunlin; McElroy, Chris; Tang, Beisha; Xia, Ying; Wang, Qing; 0000-0002-1336-348X (Jin, Kunlin) (Springer Nature, 2016-09-29)
      The nuclear orphan receptor, Nur77 plays important roles in neuroimflammation, apoptosis, and dopaminergic neurodegeneration. We conducted a further mechanistic investigation into the association of Nur77 with cell death. ...
    • Of Cross-immunity, Herd Immunity and Country-specific Plans: Experiences from COVID-19 in India 

      Chakrabarti, Sankha Shubhra; Kaur, Upinder; Singh, Anup; Chakrabarti, Suddhachitta; Krishnatreya, Manigreeva; Agrawal, Bimal Kumar; Mittal, Amit; Singh, Amit; Khanna, Rahul; Gambhir, Indrajeet Singh; Jin, Kunlin; Chakrabarti, Sasanka; 0000-0002-1336-348X (Jin, Kunlin) (JKL International, 2020-12-01)
      India has witnessed a high number of COVID-19 cases, but mortality has been quite low, and most cases have been asymptomatic or mild. In early April, we had hypothesized a low COVID-19 mortality in India, based on the ...
    • Peripheral Circulating Exosomal miRNAs Potentially Contribute to the Regulation of Molecular Signaling Networks in Aging 

      Zhang, Hongxia; Jin, Kunlin; 0000-0002-1336-348X (Jin, Kunlin) (MDPI, 2020-03-11)
      People are living longer than ever. Consequently, they have a greater chance for developing a functional impairment or aging-related disease, such as a neurodegenerative disease, later in life. Thus, it is important to ...
    • Rapidly Progressive Dementia with Asymmetric Rigidity Following ChAdOx1 nCoV-19 Vaccination 

      Chakrabarti, Sankha Shubhra; Tiwari, Ashutosh; Jaiswal, Sumit; Kaur, Upinder; Kumar, Ishan; Mittal, Amit; Singh, Anup; Jin, Kunlin; Chakrabarti, Sasanka; 0000-0002-1336-348X (Jin, Kunlin) (JKL International, 2022-06-01)
    • Recent Progress in Vascular Aging: Mechanisms and Its Role in Age-related Diseases 

      Xu, Xianglai; Wang, Brian; Ren, Changhong; Hu, Jiangnan; Greenberg, David A.; Chen, Tianxiang; Xie, Liping; Jin, Kunlin; 0000-0002-1336-348X (Jin, Kunlin) (JKL International, 2017-07-21)
      As with many age-related diseases including vascular dysfunction, age is considered an independent and crucial risk factor. Complicated alterations of structure and function in the vasculature are linked with aging hence, ...
    • SDF-1/CXCR7 Chemokine Signaling is Induced in the Peri-Infarct Regions in Patients with Ischemic Stroke 

      Zhang, Yu; Zhang, Hongxia; Lin, Siyang; Chen, Xudong; Yao, Yu; Mao, XiaoOu; Shao, Bei; Zhuge, Qichuan; Jin, Kunlin; 0000-0002-1336-348X (Jin, Kunlin) (JKL International, 2018-04-01)
      Stromal-derived factor-1 (SDF-1, also known as CXCL12) and its receptors CXCR4 and CXCR7 play important roles in brain repair after ischemic stroke, as SDF-1/ CXCR4/CXCR7 chemokine signaling is critical for recruiting stem ...
    • The Effect of IDO on Neural Progenitor Cell Survival Under Oxygen Glucose Deprivation 

      Wang, Jixian; Wang, Brian; Jiang, Lei; Zhou, Kaijing; Yang, Guo-Yuan; Jin, Kunlin; 0000-0002-1336-348X (Jin, Kunlin) (JKL International, 2020-10-30)
      Objective: Indoleamine 2,3-dioxygenase (IDO) activity plays an important role in many neurological disorders in the central nervous system, which may be associated with immunomodulation or anti-inflammatory activity. ...
    • The Pathogenetic Dilemma of Post-COVID-19 Mucormycosis in India 

      Chakrabarti, Sankha Shubhra; Kaur, Upinder; Aggarwal, Sushil Kumar; Kanakan, Ahalya; Saini, Adesh; Agrawal, Bimal Kumar; Jin, Kunlin; Chakrabarti, Sasanka; 0000-0002-1336-348X (Jin, Kunlin) (JKL International, 2022-02-01)
      There has been a surge of mucormycosis cases in India in the wake of the second wave of COVID-19 with more than 40000 cases reported. Mucormycosis in patients of COVID-19 in India is at variance to other countries where ...
    • The Prognostic Value of Serum Cytokines in Patients with Acute Ischemic Stroke 

      Li, Xianmei; Lin, Siyang; Chen, Xiaoli; Huang, Wensi; Li, Qian; Zhang, Hongxia; Chen, Xudong; Yang, Shaohua; Jin, Kunlin; Shao, Bei; 0000-0002-1336-348X (Jin, Kunlin); 0000-0002-0405-0887 (Yang, Shaohua) (JKL International, 2019-06-01)
      The inflammatory response is an unavoidable process and contributes to the destruction of cerebral tissue during the acute ischemic stroke (AIS) phase and has not been addressed fully to date. Insightful understanding of ...
    • Traditional Chinese Medicine and Western Medicine Share Similar Philosophical Approaches to Fight COVID-19 

      Zhao, Fangfang; Yang, Zhenhong; Wang, Ningqun; Jin, Kunlin; Luo, Yumin; 0000-0002-1336-348X (Jin, Kunlin) (JKL International, 2021-08-01)
      Though disciplines in the same field, modern medicine (Western medicine) and traditional medicine (Traditional Chinese medicine, TCM) have been viewed as two distinct and divergent fields of medicine and thus differ greatly ...
    • Transplantation of ACE2(-) Mesenchymal Stem Cells Improves the Outcome of Patients with COVID-19 Pneumonia 

      Leng, Zikuan; Zhu, Rongjia; Hou, Wei; Feng, Yingmei; Yang, Yanlei; Han, Qin; Shan, Guangliang; Meng, Fanyan; Du, Dongshu; Wang, Shihua; Fan, Junfen; Wang, Wenjing; Deng, Luchan; Shi, Hongbo; Li, Hongjun; Hu, Zhongjie; Zhang, Fengchun; Gao, Jinming; Liu, Hongjian; Li, Xiaoxia; Zhao, Yangyang; Yin, Kan; He, Xijing; Gao, Zhengchao; Wang, Yibin; Yang, Bo; Jin, Ronghua; Stambler, Ilia; Lim, Lee Wei; Su, Huanxing; Moskalev, Alexey; Cano, Antonio; Chakrabarti, Sasanka; Min, Kyung-Jin; Ellison-Hughes, Georgina; Caruso, Calogero; Jin, Kunlin; Zhao, Robert Chunhua; 0000-0002-1336-348X (Jin, Kunlin) (JKL International, 2020-03-09)
      A coronavirus (HCoV-19) has caused the novel coronavirus disease (COVID-19) outbreak in Wuhan, China. Preventing and reversing the cytokine storm may be the key to save the patients with severe COVID-19 pneumonia. Mesenchymal ...