Now showing items 1-20 of 32

    • A type-II positive allosteric modulator of α7 nAChRs reduces brain Injury and Improves neurological function after focal cerebral ischemia in rats 

      Sun, Fen; Jin, Kunlin; Uteshev, Victor (PLoS ONE, 2013)
      In the absence of clinically-efficacious therapies for ischemic stroke there is a critical need for development of new therapeutic concepts and approaches for prevention of brain injury secondary to cerebral ischemia. This ...
    • Nur77 exacerbates PC12 cellular injury in vitro by aggravating mitochondrial impairment and endoplasmic reticulum stress 

      Gao, Huimin; Chen, Zhaoyu; Fu, Yongmei; Yang, Xiaoyan; Weng, Ruihui; Wang, Rui; Lu, Jianjun; Pan, Mengqiu; Jin, Kunlin; McElroy, Chris; Tang, Beisha; Xia, Ying; Wang, Qing; 0000-0002-1336-348X (Jin, Kunlin) (Springer Nature, 2016-09-29)
      The nuclear orphan receptor, Nur77 plays important roles in neuroimflammation, apoptosis, and dopaminergic neurodegeneration. We conducted a further mechanistic investigation into the association of Nur77 with cell death. ...
    • Combining Injectable Plasma Scaffold with Mesenchymal Stem/Stromal Cells for Repairing Infarct Cavity after Ischemic Stroke 

      Zhang, Hongxia; Sun, Fen; Wang, Jixian; Xie, Luokun; Yang, Chenqi; Pan, Mengxiong; Shao, Bei; Yang, Guo-Yuan; Yang, Shao-Hua; Zhuge, Qichuan; Jin, Kunlin; 0000-0002-1336-348X (Jin, Kunlin); 0000-0002-0405-0887 (Yang, Shaohua) (JKL International, 2017-04-01)
      Stroke survivors are typically left with structural brain damage and associated functional impairment in the chronic phase of injury, for which few therapeutic options exist. We reported previously that transplantation of ...
    • Cystatin C as a potential therapeutic mediator against Parkinson's disease via VEGF-induced angiogenesis and enhanced neuronal autophagy in neurovascular units 

      Zou, Jing; Chen, Zhaoyu; Wei, Xiaobo; Chen, Zhigang; Fu, Yongmei; Yang, Xiaoyan; Chen, Dan; Wang, Rui; Jenner, Peter; Lu, Jia-Hong; Li, Min; Zhang, Zhuohua; Tang, Beisha; Jin, Kunlin; Wang, Qing; 0000-0002-1336-348X (Jin, Kunlin) (Springer Nature, 2017-06-01)
      Cystatin C (CYS C, Cst3) is an endogenous cysteine protease inhibitor that plays neuroprotective roles in neurodegenerative diseases. We aimed to explore the association of CYS C with Parkinson's disease (PD) models and ...
    • Recent Progress in Vascular Aging: Mechanisms and Its Role in Age-related Diseases 

      Xu, Xianglai; Wang, Brian; Ren, Changhong; Hu, Jiangnan; Greenberg, David A.; Chen, Tianxiang; Xie, Liping; Jin, Kunlin; 0000-0002-1336-348X (Jin, Kunlin) (JKL International, 2017-07-21)
      As with many age-related diseases including vascular dysfunction, age is considered an independent and crucial risk factor. Complicated alterations of structure and function in the vasculature are linked with aging hence, ...
    • Age-related Impairment of Vascular Structure and Functions 

      Xu, Xianglai; Wang, Brian; Ren, Changhong; Hu, Jiangnan; Greenberg, David A.; Chen, Tianxiang; Xie, Liping; Jin, Kunlin; 0000-0002-1336-348X (Jin, Kunlin) (JKL International, 2017-10-01)
      Among age-related diseases, cardiovascular and cerebrovascular diseases are major causes of death. Vascular dysfunction is a key characteristic of these diseases wherein age is an independent and essential risk factor. The ...
    • Aging Systemic Milieu Impairs Outcome after Ischemic Stroke in Rats 

      Pan, Mengxiong; Wang, Peng; Zheng, Chengcai; Zhang, Hongxia; Lin, Siyang; Shao, Bei; Zhuge, Qichuan; Jin, Kunlin; 0000-0002-1336-348X (Jin, Kunlin) (JKL International, 2017-10-01)
      Compelling evidence indicates that factors in the blood can profoundly reverse aging-related impairments, as exposure of aged mice to young blood rejuvenates adult stem cell function, improves cognition, and ameliorates ...
    • SDF-1/CXCR7 Chemokine Signaling is Induced in the Peri-Infarct Regions in Patients with Ischemic Stroke 

      Zhang, Yu; Zhang, Hongxia; Lin, Siyang; Chen, Xudong; Yao, Yu; Mao, XiaoOu; Shao, Bei; Zhuge, Qichuan; Jin, Kunlin; 0000-0002-1336-348X (Jin, Kunlin) (JKL International, 2018-04-01)
      Stromal-derived factor-1 (SDF-1, also known as CXCL12) and its receptors CXCR4 and CXCR7 play important roles in brain repair after ischemic stroke, as SDF-1/ CXCR4/CXCR7 chemokine signaling is critical for recruiting stem ...
    • Hypoxia, hibernation and Neuroprotection: An Experimental Study in Mice 

      Ren, Changhong; Li, Sijie; Rajah, Gary; Shao, Guo; Lu, Guowei; Han, Rongrong; Huang, Qingjian; Li, Haiyan; Ding, Yuchuan; Jin, Kunlin; Ji, Xunming; 0000-0002-1336-348X (Jin, Kunlin) (JKL International, 2018-08-01)
      Hibernation is a unique physiological state that evolved to survive periods of food shortages. It is characterized by profound decreases in metabolic rate, body temperature and physiological functions. Studies have shown ...
    • Limb Ischemic Conditioning Improved Cognitive Deficits via eNOS-Dependent Augmentation of Angiogenesis after Chronic Cerebral Hypoperfusion in Rats 

      Ren, Changhong; Li, Ning; Li, Sijie; Han, Rongrong; Huang, Qingjian; Hu, Jiangnan; Jin, Kunlin; Ji, Xunming; 0000-0002-1336-348X (Jin, Kunlin) (JKL International, 2018-10-01)
      Intracranial and extracranial arterial stenosis, the primary cause of chronic cerebral hypoperfusion (CCH), is a critical reason for the pathogenesis of vascular dementia and Alzheimer's disease characterized by cognitive ...
    • Exosomes Derived From Bone Mesenchymal Stem Cells Ameliorate Early Inflammatory Responses Following Traumatic Brain Injury 

      Ni, Haoqi; Yang, Su; Siaw-Debrah, Felix; Hu, Jiangnan; Wu, Ke; He, Zibin; Yang, Jianjing; Pan, Sishi; Lin, Xiao; Ye, Haotuo; Xu, Zhu; Wang, Fan; Jin, Kunlin; Zhuge, Qichuan; Huang, Lijie; 0000-0002-1336-348X (Jin, Kunlin) (Frontiers Media S.A., 2019-01-24)
      Traumatic brain injury (TBI) is a leading cause of mortality and disability worldwide. Although treatment guidelines have been developed, no best treatment option or medicine for this condition exists. Recently, mesenchymal ...
    • A Microcirculatory Theory of Aging 

      Jin, Kunlin; 0000-0002-1336-348X (Jin, Kunlin) (JKL International, 2019-06-01)
      Aging is the progressive decline of physiological functions necessary for survival and reproduction. In gaining a better understanding of the inevitable aging process, the hope is to preserve, promote, or delay healthy ...
    • The Prognostic Value of Serum Cytokines in Patients with Acute Ischemic Stroke 

      Li, Xianmei; Lin, Siyang; Chen, Xiaoli; Huang, Wensi; Li, Qian; Zhang, Hongxia; Chen, Xudong; Yang, Shaohua; Jin, Kunlin; Shao, Bei; 0000-0002-1336-348X (Jin, Kunlin); 0000-0002-0405-0887 (Yang, Shaohua) (JKL International, 2019-06-01)
      The inflammatory response is an unavoidable process and contributes to the destruction of cerebral tissue during the acute ischemic stroke (AIS) phase and has not been addressed fully to date. Insightful understanding of ...
    • AMPK Signaling Regulates the Age-Related Decline of Hippocampal Neurogenesis 

      Wang, Brian Z.; Yang, Jane J.; Zhang, Hongxia; Smith, Charity A.; Jin, Kunlin; 0000-0002-1336-348X (Jin, Kunlin) (JKL International, 2019-10-01)
      The global incidence of age-associated neurological diseases is expected to rise with increasingly greying societies. In the aged brain, there is a dramatic decrease in the number of stem cells, which is a main cause for ...
    • Microglia exacerbate white matter injury via complement C3/C3aR pathway after hypoperfusion 

      Zhang, Lin-Yuan; Pan, Jiaji; Mamtilahun, Muyassar; Zhu, Yuan; Wang, Liping; Venkatesh, Ashwin; Shi, Rubing; Tu, Xuanqiang; Jin, Kunlin; Wang, Yongting; Zhang, Zhijun; Yang, Guo-Yuan; 0000-0002-1336-348X (Jin, Kunlin) (Ivyspring International Publisher, 2020-01-01)
      Microglial activation participates in white matter injury after cerebral hypoperfusion. However, the underlying mechanism is unclear. Here, we explore whether activated microglia aggravate white matter injury via complement ...
    • Transplantation of ACE2(-) Mesenchymal Stem Cells Improves the Outcome of Patients with COVID-19 Pneumonia 

      Leng, Zikuan; Zhu, Rongjia; Hou, Wei; Feng, Yingmei; Yang, Yanlei; Han, Qin; Shan, Guangliang; Meng, Fanyan; Du, Dongshu; Wang, Shihua; Fan, Junfen; Wang, Wenjing; Deng, Luchan; Shi, Hongbo; Li, Hongjun; Hu, Zhongjie; Zhang, Fengchun; Gao, Jinming; Liu, Hongjian; Li, Xiaoxia; Zhao, Yangyang; Yin, Kan; He, Xijing; Gao, Zhengchao; Wang, Yibin; Yang, Bo; Jin, Ronghua; Stambler, Ilia; Lim, Lee Wei; Su, Huanxing; Moskalev, Alexey; Cano, Antonio; Chakrabarti, Sasanka; Min, Kyung-Jin; Ellison-Hughes, Georgina; Caruso, Calogero; Jin, Kunlin; Zhao, Robert Chunhua; 0000-0002-1336-348X (Jin, Kunlin) (JKL International, 2020-03-09)
      A coronavirus (HCoV-19) has caused the novel coronavirus disease (COVID-19) outbreak in Wuhan, China. Preventing and reversing the cytokine storm may be the key to save the patients with severe COVID-19 pneumonia. Mesenchymal ...
    • Peripheral Circulating Exosomal miRNAs Potentially Contribute to the Regulation of Molecular Signaling Networks in Aging 

      Zhang, Hongxia; Jin, Kunlin; 0000-0002-1336-348X (Jin, Kunlin) (MDPI, 2020-03-11)
      People are living longer than ever. Consequently, they have a greater chance for developing a functional impairment or aging-related disease, such as a neurodegenerative disease, later in life. Thus, it is important to ...
    • COVID-19 in India: Are Biological and Environmental Factors Helping to Stem the Incidence and Severity? 

      Chakrabarti, Sankha Shubhra; Kaur, Upinder; Banerjee, Anindita; Ganguly, Upsana; Banerjee, Tuhina; Saha, Sarama; Parashar, Gaurav; Prasad, Suvarna; Chakrabarti, Suddhachitta; Mittal, Amit; Agrawal, Bimal Kumar; Rawal, Ravindra Kumar; Zhao, Rovert Chunhua; Gambhir, Indrajeet Singh; Khanna, Rahul; Shetty, Ashok K.; Jin, Kunlin*; Chakrabarti, Sasanka; 0000-0002-1336-348X (Jin, Kunlin) (JKL International, 2020-05-09)
      The ongoing Corona virus (COVID-19) pandemic has witnessed global political responses of unimaginable proportions. Many nations have implemented lockdowns that involve mandating citizens not to leave their residences for ...
    • The Effect of IDO on Neural Progenitor Cell Survival Under Oxygen Glucose Deprivation 

      Wang, Jixian; Wang, Brian; Jiang, Lei; Zhou, Kaijing; Yang, Guo-Yuan; Jin, Kunlin; 0000-0002-1336-348X (Jin, Kunlin) (JKL International, 2020-10-30)
      Objective: Indoleamine 2,3-dioxygenase (IDO) activity plays an important role in many neurological disorders in the central nervous system, which may be associated with immunomodulation or anti-inflammatory activity. ...
    • Ablation of GSDMD Improves Outcome of Ischemic Stroke Through Blocking Canonical and Non-canonical Inflammasomes Dependent Pyroptosis in Microglia 

      Wang, Kankai; Sun, Zhezhe; Ru, Junnan; Wang, Simin; Huang, Lijie; Ruan, Linhui; Lin, Xiao; Jin, Kunlin; Zhuge, Qichuan; Yang, Su; 0000-0002-1336-348X (Jin, Kunlin) (Frontiers Media S.A., 2020-11-23)
      Ischemia/reperfusion (I/R) injury is a significant cause of mortality and long-term disability worldwide. Recent evidence has proved that pyroptosis, a novel cell death form, contributes to inflammation-induced neuron death ...