Browsing 2019 by Issue Date
Now showing items 1-20 of 302
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Rapamycin decreases presenilin-1 in SK-N-SH cells
(2019-03-05)Purpose: Presenilin-1 (PS1) protein is the catalytic subunit of the γ-secretase complex, and participates in the processing of β-amyloid precursor protein (APP) to produce Aβ peptide and Notch 1 receptor to release Notch ... -
Analysis of mitochondrial protein sulfenation during aging in the rat brain
(2019-03-05)Purpose: The purpose of the present study was to identify mitochondrial proteins that undergo changes in cysteine sulfenation during aging. Methods: Studies were conducted in rats when they were 5 or 30 months of age. ... -
Recruiting elders into research
(2019-03-05)Hypothesis/Objective Recruiting older adults into research is a complex task and utilizing ineffective recruitment methods is a waste of research grant money and researcher time. Research in aging and Alzheimer’s disease ... -
Developing Interprofessional Collaboration to Advance Innovative Service Delivery in Geriatric Health Settings
(2019-03-05)Purpose: Interprofessional collaboration is essential in geriatric healthcare settings due to the complex needs of older adults. The University of North Texas Health Science Center and Texas Christian University’s Harris ... -
Intermittent hypoxia training: novel intervention for treating mild cognitive impairment
(2019-03-05)Purpose: Although intermittent hypoxic training (IHT) has proven effective against various clinical disorders, its impact on mild cognitive impairment (MCI) is unknown. This study was to test if IHT was safe as a novel ... -
Genome-wide study highlights novel genes associated with Alzheimer’s-Hypertension comorbidity showing utility over CSF biomarkers
(2019-03-05)Purpose: The aging population (65 and older) is heavily burdened with comorbidities. As the incidence of Alzheimer’s continues to rise in the aging demographic, understanding underlying causes of prevalent comorbid patterns ... -
The Impact of High Intensity Aerobic Exercise on Cardiovascular Function in Older Adults
(2019-03-05)1 Purpose Cardiovascular disease (CVD) is a leading cause of mortality in the United States, and age alone is a risk factor for developing CVD1. Regular aerobic exercise can help prevent arterial stiffening that occurs ... -
Scripted Improvisation and Effects on Emotional Resiliency, Stress, and Positive Aspects of Caregiving
(2019-03-05)Background: As the United States population continues to age, more people will be diagnosed with Alzheimer’s Disease (AD) and dementia. Along with this increase in diagnosis comes an increase in the need for people to serve ... -
Mechanisms Underlying Membrane Androgen Receptor-Induced Neurodegeneration
(2019-03-05)Purpose: A common characteristic of several neurodegenerative disorders is oxidative stress (OS). Many neurodegenerative disorders are more prevalent in men and postmenopausal women. Our lab has shown testosterone via a ... -
Analysis of 436,390 genetic variants in 9,765 elderly individuals implicates TOMM40, MARK4, CLPTM1 and VDAC1/FSTL4 in the inverse relationship between Alzheimer's and cancer
(2019-03-05)Purpose A rapidly aging demographic, aged 65 and older, is expected to double by 2060 reaching 98 million and creating demands for better healthcare. While the number of co-occurring diseases increase in the aging population, ... -
Behavioral profiling of aged glutathione-deficient mice exposed to an oxidative stressor
(2019-03-05)Purpose Aging is associated with a decrease in brain function and vitality, along with an increased risk to stressors. Oxidative stress is a mechanism associated with aging, in which antioxidant defenses are overcome by ... -
STRUCTURAL AND FUNCTIONAL INSIGHTS INTO CRISPR-CAS9 CATALYTIC ACTIVATION AND SPECIFICITY ENHANCEMENT
(2019-03-05)CRISPR/Cas9 has been repurposed as a powerful genome editing tool, with immense potential toward therapeutic applications. Despite recent advances in understanding DNA recognition and cleavage by Cas9, consistent structural ... -
Translational research program utilizing the rHDL drug delivery platform.
(2019-03-05)Translational research program utilizing the rHDL drug delivery platform. Sabnis N1, Raut S1, Mooberry L1, Nair M1, Nagarajan B1, Garud A1, Dossou A1, Remaley A2, Graham J3 , Sood AK4, McConathy WJ1, Lacko AG1. UNTHSC1, ... -
Optimization of Antisense Oligonucleotides (ASO) Entrapped HDL Mimetic Lipo-peptide Nanoparticles
(2019-03-05)Purpose: Antisense Oligonucleotides (ASO) are short single stranded DNA oligomers that represent a novel class of Nucleic acid therapeutics with high potential to treat a broad range of disorders including cancer by ... -
A Liposomal Platform Using a Microfluidic Mixing Method for Drug Delivery and Targeting of Metastatic Prostate Cancer
(2019-03-05)Purpose: The success rate for the treatment of localized prostate cancer (PCa) is very high. However, the overall survival rate for patients with metastatic PCa drops to 28%. Bone is the primary metastatic site in 90% of ... -
Identifying Top Gene Contributors to Triple Negative Breast Cancer Health Disparities Among African American Women: A Machine Learning Approach
(2019-03-05)Purpose: Triple Negative Breast Cancer (TNBC) is a breast cancer subtype which multiple studies have shown to be disproportionately prevalent among premenopausal African American women. The factors contributing to the TNBC ... -
HIGH EXPRESSION OF MIEN1 IN BREAST CANCER CORRELATES WITH POOR SURVIVAL OUTCOME
(2019-03-05)PURPOSE: Breast cancer is the second leading cause of cancer-related deaths in women. Metastasis accounts for majority of breast cancer deaths. It remains a major barrier to cancer treatment due to limitations in diagnosis ... -
Reconstituted high-density lipoprotein as a potential delivery vehicle for TAMs re-polarization agents
(2019-03-05)Purpose: As part of the tumor microenvironment, tumor-associated macrophages (TAMs) form a functionally heterogeneous population where the pro-inflammatory M1 type macrophages exert anti-tumoral function by enabling the ... -
Phosphorylation of Annexin A2 is Essential for its Association with Exosomes in Triple Negative Breast Cancer
(2019-03-05)Introduction: Studying triple negative breast cancer (TNBC) is the utmost importance as treatment lacks targeted-based therapies. High expression of exosomal Annexin A2 (AnxA2), a Ca+2-dependent phospholipid binding protein, ... -
Contrasting effects of protein kinase C-eta on apoptosis versus senescence
(2019-03-05)Purpose: Breast cancer is the most commonly diagnosed cancer in women with over 252,000 women in the United states getting diagnosed and more than 40,000 dying each year. Lack of cell death by apoptosis can cause cancer ...