Browsing Cancer by Issue Date
Now showing items 1-20 of 25
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Translational research program utilizing the rHDL drug delivery platform.
(2019-03-05)Translational research program utilizing the rHDL drug delivery platform. Sabnis N1, Raut S1, Mooberry L1, Nair M1, Nagarajan B1, Garud A1, Dossou A1, Remaley A2, Graham J3 , Sood AK4, McConathy WJ1, Lacko AG1. UNTHSC1, ... -
Optimization of Antisense Oligonucleotides (ASO) Entrapped HDL Mimetic Lipo-peptide Nanoparticles
(2019-03-05)Purpose: Antisense Oligonucleotides (ASO) are short single stranded DNA oligomers that represent a novel class of Nucleic acid therapeutics with high potential to treat a broad range of disorders including cancer by ... -
A Liposomal Platform Using a Microfluidic Mixing Method for Drug Delivery and Targeting of Metastatic Prostate Cancer
(2019-03-05)Purpose: The success rate for the treatment of localized prostate cancer (PCa) is very high. However, the overall survival rate for patients with metastatic PCa drops to 28%. Bone is the primary metastatic site in 90% of ... -
Identifying Top Gene Contributors to Triple Negative Breast Cancer Health Disparities Among African American Women: A Machine Learning Approach
(2019-03-05)Purpose: Triple Negative Breast Cancer (TNBC) is a breast cancer subtype which multiple studies have shown to be disproportionately prevalent among premenopausal African American women. The factors contributing to the TNBC ... -
HIGH EXPRESSION OF MIEN1 IN BREAST CANCER CORRELATES WITH POOR SURVIVAL OUTCOME
(2019-03-05)PURPOSE: Breast cancer is the second leading cause of cancer-related deaths in women. Metastasis accounts for majority of breast cancer deaths. It remains a major barrier to cancer treatment due to limitations in diagnosis ... -
Reconstituted high-density lipoprotein as a potential delivery vehicle for TAMs re-polarization agents
(2019-03-05)Purpose: As part of the tumor microenvironment, tumor-associated macrophages (TAMs) form a functionally heterogeneous population where the pro-inflammatory M1 type macrophages exert anti-tumoral function by enabling the ... -
Phosphorylation of Annexin A2 is Essential for its Association with Exosomes in Triple Negative Breast Cancer
(2019-03-05)Introduction: Studying triple negative breast cancer (TNBC) is the utmost importance as treatment lacks targeted-based therapies. High expression of exosomal Annexin A2 (AnxA2), a Ca+2-dependent phospholipid binding protein, ... -
Contrasting effects of protein kinase C-eta on apoptosis versus senescence
(2019-03-05)Purpose: Breast cancer is the most commonly diagnosed cancer in women with over 252,000 women in the United states getting diagnosed and more than 40,000 dying each year. Lack of cell death by apoptosis can cause cancer ... -
Delayed Diagnosis of Langerhans Cell Histiocytosis: A Case Series
(2019-03-05)Background: Langerhans Cell Histiocytosis (LCH) is a rare clonal proliferative disease affecting the dendritic-derived, antigen-presenting Langerhans cells. Formerly termed Histiocytosis X, LCH encompasses a wide constellation ... -
Diffuse Cutaneous Mastocytosis and its potential comorbidities in pediatric patients – a case study.
(2019-03-05)Background: Mastocytosis is the pathologic proliferation and accumulation of mast cells in various tissues of the body. There are different forms of mastocytosis that can present in pediatric patients including systemic ... -
Bone Pain as a Clinical Presentation of Acute Lymphoblastic Leukemia
(2019-03-05)Introduction: Acute lymphoblastic leukemia (ALL) is the most common malignancy in children, accounting for approximately 1/3 of pediatric cancers. Treatment of ALL has progressed extensively over the years, and approximately ... -
Long Term Survival in Pediatric Renal Cell Carcinoma despite multiple relapses: A Case Study
(2019-03-05)Background Although common in adults, renal cell carcinoma (RCC) is extremely rare in pediatric populations, comprising of less than 5% of malignant renal tumors. Literature on the topic is scarce, and there currently is ... -
Understanding the Mechanism of Action of Copper-Tolfenamic Acid’s Anti-cancer Activity in Pancreatic Cancer Cells
(2019-03-05)Purpose: Non-steroidal anti-inflammatory (NSAID) agents have been proven to have anti-cancer activity. Our group is investigating the use of NSAIDs as sensitizing agents to use alongside standard chemotherapy. This ... -
Exploring Less Toxic Combination Treatment Options for Inducing Anti-Cancer Activity in Medulloblastoma Cells
(2019-03-05)Purpose.Medulloblastoma (MB) is the most common type of malignant pediatric brain cancer and is typically located in the posterior fossa. There are four subgroups within MB: Wnt, Sonic-Hedgehog, Group 3, and Group 4. Due ... -
Lipoprotein Based Targeted Therapy for AML
(2019-03-05)Background: Acute myeloid leukemia (AML) is the most common acute leukemia in adults; it is only cured in less than 50% of the patients that are diagnosed with the disease. A new approach to the AML treatment is proposed ... -
The role of Specificity Protein 1 and downstream target Survivin in Ovarian Adenocarcinoma Survival and Prognosis
(2019-03-05)Purpose: Ovarian adenocarcinoma is a solid proliferation of ovarian glandular epithelium. These are the most threatening types of gynecologic malignancies. Although many risk factors are involved in determining prognosis, ... -
Survivin as a New Target for Neuroblastoma
(2019-03-05)Background: Neuroblastoma is the most common solid peripheral nervous system pediatric tumor found in pediatrics. Neuroblastoma (NB) commonly metastasizes through the lymphatic system and bone marrow, and has a particularly ... -
Trial of Pazopanib in a Multiply Relapsed Osteosarcoma Patient
(2019-03-05)Background: Osteosarcomas (OS) are typically found among adolescents and young adults and usually affect the long bones around the knee. The current treatment options for relapsed OS include surgery, chemotherapy, targeted ... -
Delayed Diagnosis of Ewing Sarcoma: A Case Series
(2019-03-05)Background: Ewing Sarcoma, the second most common bone cancer in adolescents, affects young adults between the ages of 15 to 24. Ewing Sarcoma presents with a variety of non-specific symptoms, including pain and possible ... -
Anti-Proliferative Effect of Copper Tolfenamic Acid in Neuroblastoma Cell Lines
(2019-03-05)Anti-Proliferative Effect of Copper Tolfenamic Acid in Neuroblastoma Cell Lines Sarah Grebennikov, Yazmin Hernandez, Rajasekhar Maram, Umesh T. Sankpal, and Riyaz Basha Background:Neuroblastoma (NB) is a neuroendocrine ...