Browsing Pharmaceutical Sciences by Issue Date
Now showing items 1-9 of 9
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3D-Printed Insert for Visualization of Liposomal Interactions with Collagen Fibers
(2019-03-05)Purpose: Nanoparticles, such as liposome, are commonly used as vehicles for drug delivery to target tissues such as tumors. However, relatively little research has focused on liposomal interactions with the tumor extracellular ... -
An Alternative Method To Quantify Surface Properties of Anti-Cancer Drugs
(2019-03-05)Purpose Physicochemical properties such as size and size distribution affect liposome formulations’ physical stability and accumulation in the target tissue. The FDA’s “Liposome Drug Products, Guidance for Industry”, 2018 ... -
Microbial Natural Product Drug Discovery Through Systematic Sampling of Diverse Texas Soils
(2019-03-05)Purpose: Microorganisms have long been a valuable source of new pharmaceutically relevant small molecules. Because of their intrinsic need to compete for scarce resources in their microenvironment, they have often adapted ... -
Asymmetric syntheses identify preferred stereochemistry in small molecule allosteric modulators of the neuropeptide Y4 receptor
(2019-03-05)PURPOSE: The neuropeptide Y4 receptor (Y4) is a GPCR belonging to a family of five receptors that bind ligands neuropeptide Y (NPY), peptide YY (PYY), and pancreatic polypeptide (PP). These ligands are hormones that play ... -
Using Autodock Tools for Automated Docking of Ligands to D2/D3 Receptors
(2019-03-05)Parkinson’s Disease (PD) is a neurodegenerative disorder of the substantia nigra, affecting roughly ten million individuals worldwide. Considering that the substantia nigra is the main player in dopamine production, ... -
Genetic Influences on Opioid Use in Low Back Pain: OPRM1 rs1799971
(2019-03-05)Purpose: The OPRM1 rs1799971 single nucleotide polymorphism (SNP) has been studied for its influence on drug abuse and opioid use. Opioids have a questionable long-term risk-benefit profile in chronic low back pain, and a ... -
Development and Characterization of In Situ Self-Assembly Nanoparticles for Oral Tissue-Targeting Delivery
(2019-03-05)Purpose: Tissue-targeting delivery system is an advanced method that improves drug concentration in tissues of interest and minimizes systemic toxicity. Drugs are encapsulated in a carrier and will be released at the site ... -
Effect of Cholesterol Content on Surface Properties of Doxil-Mimicking Liposomes
(2019-03-05)Purpose:The use of nanoparticles (NPs) for drug delivery has gained a lot of attention from biomedical researchers in the last few decades. This is primarily because NPs are of an extremely small size that enables them to ... -
Investigating Effects of Pegylation of the Surface Tension of Liposomes used in the Treatment of Breast Cancer
(2019-03-05)Purpose: In recent years there have been many advancements in nanomedicine as potential delivery systems for the treatment of various types of cancer. Two formulations on the market, Doxil® and Myocet®, are made of ...