Texas College of Osteopathic Medicine
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A Multisite Qualitative Analysis of Perceived Roles in Medication Safety: Older Adults' Perspectives
(Cleveland Clinic, 2023-03-04)Older adults and caregivers play an essential role in medication safety; however, self-perception of their and health professionals' roles in medication safety is not well-understood. The objective of our study was to ... -
Hyperparameter Tuning with High Performance Computing Machine Learning for Imbalanced Alzheimer's Disease Data
(MDPI, 2022-11-17)Accurate detection is still a challenge in machine learning (ML) for Alzheimer's disease (AD). Class imbalance in imbalanced AD data is another big challenge for machine-learning algorithms working under the assumption ... -
Predicting overall survival in diffuse glioma from the presurgical connectome
(Springer Nature, 2022-11-06)Diffuse gliomas are incurable brain tumors, yet there is significant heterogeneity in patient survival. Advanced computational techniques such as radiomics show potential for presurgical prediction of survival and other ... -
Application of Structural Retinal Biomarkers to Detect Cognitive Impairment in a Primary Care Setting
(IOS Press, 2023-02-02)BACKGROUND: Despite the diagnostic accuracy of advanced neurodiagnostic procedures, the detection of Alzheimer's disease (AD) remains poor in primary care. There is an urgent need for screening tools to aid in the detection ... -
Implementation-effectiveness trial of systematic family health history based risk assessment and impact on clinical disease prevention and surveillance activities
(BioMed Central Ltd., 2022-12-07)BACKGROUND: Systematically assessing disease risk can improve population health by identifying those eligible for enhanced prevention/screening strategies. This study aims to determine the clinical impact of a systematic ... -
A Collaborative Implementation Strategy to Increase Falls Prevention Training Using the Age-Friendly Health Systems Approach
(MDPI, 2022-05-12)Falls in the home and in community environments are the leading cause of injuries and long-term disabilities for the aging population. The purpose of this study was to examine outcomes of a partnership among an academic ... -
Aggregated student confidence estimates support continuous quality improvements in a competencies-oriented curriculum
(BMJ Publishing Group Ltd., 2019-03-08)Introduction: Competencies oriented medical curricula are intended to support the development of those specific tasks likely to improve patient care outcomes. In 2005, our institution developed curricular objectives and ... -
Willingness of a Multiethnic Immigrant Population to Donate Biospecimens for Research Purposes
(Springer Nature, 2021-07-26)This cross-sectional study explores the willingness to donate biospecimens for research purposes among six refugee communities in North Texas (spanning Myanmar, Central Africa, Somalia, Nepal, Arabic speaking countries, ... -
Uptake of cancer screenings among a multiethnic refugee population in North Texas, 2014-2018
(PLOS, 2020-03-30)BACKGROUND: Refugees are less likely than US born populations to receive cancer screenings. Building Bridges is a community health worker prevention program designed to increase refugee's cancer screening uptake. The purpose ... -
Feasibility Trial of an eHealth Intervention for Health-Related Quality of Life: Implications for Managing Patients with Chronic Pain during the COVID-19 Pandemic
(MDPI, 2020-10-01)PURPOSE: This study was conducted to determine the feasibility of providing an eHealth intervention for health-related quality of life (HRQOL) to facilitate patient self-management. METHODS: A randomized controlled trial ... -
Analysis of the Patient-Physician Relationship, Race, and Pain Control and Physical Function Among Adults With Chronic Low Back Pain
(American Medical Association, 2022-06-01)Importance: Racial and ethnic disparities in pain outcomes are widely reported in the United States. However, the impact of the patient-physician relationship on such outcomes remains unclear. Objective: To determine whether ... -
Generating a Future Vision of Patient Safety: A Pilot Program to Test the Integration of Certified Professional in Patient Safety Curriculum into Undergraduate Medical Education
(Sage Publications, 2021-07-28)Preventable healthcare-associated harm results in significant morbidity and mortality in the United States, costing nearly 400 000 patient lives annually. The Institute for Healthcare Improvement provides high-quality ... -
Neurocognitive effects associated with proprotein convertase subtilisin-kexin type 9 inhibitor use: a narrative review
(Sage Publications, 2021-03-08)Neurocognitive adverse events have been observed with the widespread use of 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors or "statins," which reduce low-density lipoprotein cholesterol (LDL-C) levels and subsequently ... -
Lewis, Gibson D.
(2022-05-25)In this Oral History, we speak with Gibson D. Lewis (Gib Lewis), namesake of the UNTHSC library and Texas Speaker of the House from 1983-1993. Lewis provides stories and insights about his political service, his involvement ... -
Proteomic profiles of prevalent mild cognitive impairment and Alzheimer's disease among adults with Down syndrome
(Wiley Periodicals, Inc., 2020-04-17)Introduction: We sought to determine if a proteomic profile approach developed to detect Alzheimer's disease (AD) in the general population would apply to adults with Down syndrome (DS). Methods: Plasma samples were ... -
Proteomic profiles for Alzheimer's disease and mild cognitive impairment among adults with Down syndrome spanning serum and plasma: An Alzheimer's Biomarker Consortium-Down Syndrome (ABC-DS) study
(Wiley Periodicals, Inc., 2020-06-30)Introduction: Previously generated serum and plasma proteomic profiles were examined among adults with Down syndrome (DS) to determine whether these profiles could discriminate those with mild cognitive impairment (MCI-DS) ... -
Accelerating Hyperparameter Tuning in Machine Learning for Alzheimer's Disease With High Performance Computing
(Frontiers Media S.A., 2021-12-08)Driven by massive datasets that comprise biomarkers from both blood and magnetic resonance imaging (MRI), the need for advanced learning algorithms and accelerator architectures, such as GPUs and FPGAs has increased. Machine ... -
Proteomic profiles of incident mild cognitive impairment and Alzheimer's disease among adults with Down syndrome
(Wiley Periodicals, Inc., 2020-05-21)Introduction: We sought to determine if proteomic profiles could predict risk for incident mild cognitive impairment (MCI) and Alzheimer's disease (AD) among adults with Down syndrome (DS). Methods: In a cohort of 398 ... -
Neurodegeneration from the AT(N) framework is different among Mexican Americans compared to non-Hispanic Whites: A Health & Aging Brain among Latino Elders (HABLE) Study
(Wiley Periodicals, LLC, 2022-02-09)Introduction: We sought to examine a magnetic resonance imaging (MRI)-based marker of neurodegeneration from the AT(N) (amyloid/tau/neurodegeneration) framework among a multi-ethnic, community-dwelling cohort. Methods: ... -
A Precision Medicine Approach to Treating Alzheimer's Disease Using Rosiglitazone Therapy: A Biomarker Analysis of the REFLECT Trials
(IOS Press, 2021-05-18)Background: The REFLECT trials were conducted to examine the treatment of mild-to-moderate Alzheimer's disease utilizing a peroxisome proliferator-activated receptor gamma agonist. Objective: To generate a predictive ...
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