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    The Regulation of P53 by Protein Kinase C in Anticancer Drug-Induced Apoptosis

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    Date
    2001-12-01
    Author
    Johnson, Cassie L.
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    Abstract
    Johnson, C., The regulation of p53 by protein kinase C in anticancer drug-induced apoptosis. Master of Science (Microbiology and Immunology), December, 2001. 43 pp., 11 figures, references, 6 titles. The tumor suppression protein p53 has been implicated in DNA damage-induced apoptosis. Previous studies demonstrated that the protein kinase C (PKC) signal transduction pathway regulates apoptosis induced by the DNA damaging agent cisplatin and is deregulated in cisplatin-resistant cells. The present study examined whether PKC influences p53 and, hence, cellular sensitivity to cisplatin. Basal p53 levels were elevated in cisplatin-resistant HeLa (HeLa/CP) cells as compared to parental HeLa cells. Cisplatin further increased p53 levels in HeLA/CP, but not in HeLA cells. However, rottlerin, a PKC-δ inhibitor that prevents cisplatin-induced apoptosis, caused p53 accumulation in HeLa cells treated with cisplatin. Rottlerin stabilized p53 in response to cisplatin in HeLa cells, whereas cisplatin alone was sufficient to stabilize p53 in HeLa/CP cells.
    Subject
    Cancer Biology
    Cell and Developmental Biology
    Cell Biology
    Cells
    Cellular and Molecular Physiology
    Life Sciences
    Medical Cell Biology
    Medical Genetics
    Medicine and Health Sciences
    Other Cell and Developmental Biology
    Basal P53
    protein kinase C
    anticancer-drug induced apoptosis
    tumor suppression protein
    DNA damage
    rottlerin
    PKC-δ
    PKC
    HeLA cells
    URI
    https://hdl.handle.net/20.500.12503/26869
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    • School of Biomedical Sciences
    • Theses and Dissertations

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