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    A DNA-Based Multiplex Screening Tool for Separation of Fragmented and Commingled Skeletal Remains

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    Ambers_ADNA_BasesMultiplex.pdf (21.04Mb)
    Date
    2007-12-01
    Author
    Ambers, Angie
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    Abstract
    Ambers, Angie, A DNA-based Multiplex Screening Tool for Separation of Fragmented and Commingled Skeletal Remains. Master of Science (Forensic Genetics), December, 2007, 63 pages, 13 tables, 19 figures, references, 38 titles. In mass death scenarios, human remains are often fragmented, scattered, and commingled. Ascertaining the number of victims and determining the victims’ identities in such scenarios is a challenging task. A DNA-based screening tool used early in the investigation of mass disasters or mass graves would provide a relatively quick way to initially assess casualty numbers and separate remains for further analysis. Such a tool would promote the most efficient allocation of resources and speed the identification process. The multiplex designed here incorporates a few genetic loci that show high variability in the human population, giving it sufficient discriminatory power for separation of commingled remains. Specifically, the multiplex includes the amelogenin sex-determining locus, D3S1358, and a 3’ (CA)n dinucleotide repeat in the mitochondrial D-loop. Further optimization/validation studies need to be conducted, and a fourth locus (D5S818) may need to be considered to increase the tool’s power of discrimination.
    Subject
    Cell and Developmental Biology
    Cell Biology
    Cells
    Forensic Science and Technology
    Genetics
    Genetics and Genomics
    Genetic Structures
    Life Sciences
    Medical Cell Biology
    Medical Genetics
    Medicine and Health Sciences
    Other Cell and Developmental Biology
    Other Genetics and Genomics
    DNA
    Multiplex screening tool
    separation
    fragmented remains
    commingled remains
    human remains
    tool
    genetic loci
    discrimination
    URI
    https://hdl.handle.net/20.500.12503/26936
    Collections
    • School of Biomedical Sciences
    • Theses and Dissertations

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