The Impact of the Mycoplasma pulmonis MALP-2 Homologue on Disease Progression
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Spear, Marcia. The Impact of Mycoplasma pulmonis MALP-2 Homologue on Disease Progression. Master of Science (Biomedical Sciences), April 2008. 64 pp., 3 tables, 8 illustrations. Using Mycoplasma pulmonis, this project looked at a possible critical component in mycoplasma disease, the MALP-2 homologue lipoprotein. Studies demonstrated other lipoproteins besides the MALP-2 homologue were critical for in vivo disease progression and in vitro macrophage IL-6, IL-12, and TNF-α cytokine production. This trend was also seen human endothelial kidney (HEK) cells transfected with toll-like receptor 1 (TLR2) and the heterodimer TLR2/6. An increase in IL-8 cytokine production seen in all stimulated HEK cell lines, indicating the lipoproteins involved in cell interactions are TLR2 mediated. This project suggests the M. pulmonis MALP-2 homologue is not the main lipoprotein involved in disease progression and cell interactions, indicating the MALP-2 homologue may not be an ideal target for vaccines or antibiotics.
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Bacterial Infections and Mycoses
Cell Anatomy
Cell and Developmental Biology
Cell Biology
Cells
Cellular and Molecular Physiology
Developmental Biology
Diseases
Immunology and Infectious Disease
Life Sciences
Medical Cell Biology
Medical Microbiology
Medical Molecular Biology
Medicine and Health Sciences
Other Cell and Developmental Biology
Virus Diseases
Mycoplasma pulmonis
MALP-2
homologue
disease progression
impact
biomedical science
mycoplasma disease
lipoprotein
in vivo disease progression
in vitro macrophage
IL-6
IL-12
TNF-α cytokine
human endothelial kidney cells
M. pulmonis
cell interaction
vaccines
antibiotics