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dc.contributor.advisorJerry Simecka
dc.creatorAgouna-Deciat, Bahrka Olivier
dc.date.accessioned2019-08-22T20:23:14Z
dc.date.available2019-08-22T20:23:14Z
dc.date.issued2003-05-01T00:00:00-07:00
dc.date.submitted2013-11-18T12:54:15-08:00
dc.identifier.urihttps://hdl.handle.net/20.500.12503/28302
dc.description.abstractAgouna-Deciat, B. Olivier, The Effect of Two Staphylococcal Global Regulators (agr and sar) on Acid Phosphatase Production in Staphylococcus aureus. Master of Science (Molecular Biology and Immunology), May 2003, 75 pp., 3 tables, 14 illustrations, 16 titles. Staphylococcus aureus produces an extensive number of cell-surface associated proteins, extracellular proteins and enzymes that contribute to its virulence. The key to better preventative or curative approaches resides in identifying and targeting the very genes and their products that play major roles in the survival of the bacteria within the host and the establishment of diseases. Two well known regulatory loci, the accessory gene regulatory (agr) and the staphylococcal accessory regulator (sar), control the expression of most S. aureus genes that encode for its virulence factors. Other virulence gene regulators have recently been isolated. Over 40 proteins and enzymes produced by S. aureus have been identified and several of them have been linked to staphylococcal pathogenesis. In this study, we attempt to determine the role of agr and sar in the regulation of the production of a secreted staphylococcal acid phosphatase (Sap) suspected to contribute to virulence.
dc.format.mimetypeapplication/pdf
dc.language.isoen
dc.subjectBacteria
dc.subjectBacterial Infections and Mycoses
dc.subjectBacteriology
dc.subjectCell and Developmental Biology
dc.subjectCell Biology
dc.subjectImmunology and Infectious Disease
dc.subjectImmunopathology
dc.subjectLife Sciences
dc.subjectMedical Cell Biology
dc.subjectMedical Molecular Biology
dc.subjectMedical Pathology
dc.subjectMedicine and Health Sciences
dc.subjectMicrobiology
dc.subjectStaphylococcal global regulator
dc.subjectacid phosphatase production
dc.subjectstaphylococcus aureus
dc.subjectagr
dc.subjectsar
dc.subjectaccessory gene regulatory
dc.subjectstaphylococcal accessory regulator
dc.subjectvirulence gene regulators
dc.subjectstaphylococcal acid phosphatase
dc.titleThe Effects of Two Staphylococcal Global Regulators (agr and sar) on Acid Phosphatase production in Staphylococcus aureus
dc.typeThesis
thesis.degree.departmentGraduate School of Biomedical Sciences
thesis.degree.disciplineMicrobiology and Immunology
thesis.degree.grantorUniversity of North Texas Health Science Center at Fort Worth
thesis.degree.nameMaster of Science
dc.contributor.committeeMemberMichael Smith
dc.type.materialtext
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