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dc.contributor.advisorRebecca L. Cunningham
dc.creatorSnyder, Brina D.
dc.date.accessioned2019-08-22T21:06:24Z
dc.date.available2019-08-22T21:06:24Z
dc.date.issued2015-08-01T00:00:00-07:00
dc.date.submitted2015-08-17T12:36:05-07:00
dc.identifier.urihttps://hdl.handle.net/20.500.12503/29073
dc.description.abstractObstructive sleep apnea (OSA) is increasingly implicated in neurodegenerative diseases. Evidence points to OSA as contributing to inflammation similar to inflammation observed in neurodegeneration. The chronic intermittent hypoxia (CIH) experienced by OSA patients may be an early contributing factor to chronic inflammation that leads to neurodegeneration. Experiments in this study identify circulating biomarkers affected by OSA and their early impact on neurodegeneration. In the first experiment, oxidative stress and inflammation were observed to increase in male rats exposed to CIH. In the second set of experiments, inflammation within brain nuclei implicated in the onset of Parkinson’s disease and Alzheimer’s disease were correlated to circulating OS elevated by CIH.
dc.format.mimetypeapplication/pdf
dc.language.isoen
dc.subjectMedical Sciences
dc.subjectMedicine and Health Sciences
dc.subjectNervous System Diseases
dc.subjectPathological Conditions, Signs and Symptoms
dc.subjectPharmacology
dc.subjectneurodegeneration
dc.subjectinflammation
dc.subjectoxidative stress
dc.subjectchronic intermittent hypoxia
dc.subjectAlzheimer's
dc.subjectParkinson's
dc.titleThe Effects of Chronic Intermittent Hypoxia on Oxidative Stress and Inflammation
dc.typeThesis
thesis.degree.departmentGraduate School of Biomedical Sciences
thesis.degree.disciplineBiomedical Sciences
thesis.degree.grantorUniversity of North Texas Health Science Center at Fort Worth
thesis.degree.nameMaster of Science
dc.contributor.committeeMemberRobert C. Barber
dc.contributor.committeeMemberWeiming Mao
dc.type.materialtext
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