Strategy to Design a Stratified Corneal Stroma Construct
Date
Authors
ORCID
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Arafeh, Reem B., Strategy to Design a Stratified Lamellar Corneal Stroma Construct. Master of Science (Biomedical Sciences), July 2nd, 2008, 103pp., 1 table, 42 illustrations, bibliography, 63 titles. Cornea is the transparent portion of the eye. Its three cellular compartments: the epithelium, stroma, and endothelium, are optimized for transparency and focusing. Although corneal grafting with donor corneas is a successful treatment to restore vision, there is an acute shortage of appropriate quality donor tissue. Tissue engineering is a new approach that addresses this shortage. In this thesis it was demonstrated that lamellar stromal structure is reproduced by stacking thin collagen films. Collagen fibril organization in the thin films directs cellular alignment allowing assembly of an orthogonal stroma construct that transmits more light than most other published constructs and is optically active. Whereas the cell alignment and lamellar arrangement were successful, optimization of optical properties is a major future goal.
Description
Keywords
Cell and Developmental Biology
Cell Biology
Cellular and Molecular Physiology
Developmental Biology
Eye Diseases
Life Sciences
Medicine and Health Sciences
Ophthalmology
Optometry
Other Cell and Developmental Biology
Sense Organs
Vision Science
Stratified lamellar corneal stroma construct
epithelium
stroma
endothelium
corneal grafting
tissue engineering
collagen fibril organization
cellular alignment
orthogonal stroma construct
optimization of optical properties