STAT6 and Its Relationship with PSA and Annexin A2 in Human Prostate Cancer
Abstract
Roth, Cherice, STAT6 and its relationship with PSA and Annexin A2 in Human Prostate Cancer. Master of Science (Biochemistry and Molecular Biology), May 2008, 49 pages, 13 illustrations, reference list, 54 titles. The increase of signal transducer and activator of transcription (STAT6) has been correlated with increased prostate tumor size as well as Gleason score. This molecule’s exact role in prostate cancer is still unknown. This research focused on the relationships of STAT6 in prostate specific antigen (PSA) expression as well as its novel interaction with annexin A2. These data show that STAT6 is involved in an alternate PSA expression pathway. It is also concluded that the interaction of STAT6 and annexin A2 increased the activated STAT6 (p-STAT) but not total STAT6. Chromatin immunoprecipitation also confirmed the novel protein-protein interaction between STAT6 and annexin A2 is nuclear.
Subject
Biochemistry
Cancer Biology
Cell and Developmental Biology
Cell Biology
Cells
Cellular and Molecular Physiology
Diseases
Life Sciences
Male Urogenital Diseases
Medical Cell Biology
Medical Molecular Biology
Medicine and Health Sciences
Microbiology
Molecular Biology
Oncology
Other Cell and Developmental Biology
Reproductive and Urinary Physiology
STAT6
relationship
PSA
Annexin A2
human prostate cancer
signal transducer and activator of transcription
prostate tumor size
Gleason score
molecule
role
expression pathway
chromatin immunoprecipitation
protein-protein interaction
Cancer Biology
Cell and Developmental Biology
Cell Biology
Cells
Cellular and Molecular Physiology
Diseases
Life Sciences
Male Urogenital Diseases
Medical Cell Biology
Medical Molecular Biology
Medicine and Health Sciences
Microbiology
Molecular Biology
Oncology
Other Cell and Developmental Biology
Reproductive and Urinary Physiology
STAT6
relationship
PSA
Annexin A2
human prostate cancer
signal transducer and activator of transcription
prostate tumor size
Gleason score
molecule
role
expression pathway
chromatin immunoprecipitation
protein-protein interaction
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