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    STAT6 and Its Relationship with PSA and Annexin A2 in Human Prostate Cancer

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    Date
    2008-05-01
    Author
    Roth, Cherice P.
    Metadata
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    Abstract
    Roth, Cherice, STAT6 and its relationship with PSA and Annexin A2 in Human Prostate Cancer. Master of Science (Biochemistry and Molecular Biology), May 2008, 49 pages, 13 illustrations, reference list, 54 titles. The increase of signal transducer and activator of transcription (STAT6) has been correlated with increased prostate tumor size as well as Gleason score. This molecule’s exact role in prostate cancer is still unknown. This research focused on the relationships of STAT6 in prostate specific antigen (PSA) expression as well as its novel interaction with annexin A2. These data show that STAT6 is involved in an alternate PSA expression pathway. It is also concluded that the interaction of STAT6 and annexin A2 increased the activated STAT6 (p-STAT) but not total STAT6. Chromatin immunoprecipitation also confirmed the novel protein-protein interaction between STAT6 and annexin A2 is nuclear.
    Subject
    Biochemistry
    Cancer Biology
    Cell and Developmental Biology
    Cell Biology
    Cells
    Cellular and Molecular Physiology
    Diseases
    Life Sciences
    Male Urogenital Diseases
    Medical Cell Biology
    Medical Molecular Biology
    Medicine and Health Sciences
    Microbiology
    Molecular Biology
    Oncology
    Other Cell and Developmental Biology
    Reproductive and Urinary Physiology
    STAT6
    relationship
    PSA
    Annexin A2
    human prostate cancer
    signal transducer and activator of transcription
    prostate tumor size
    Gleason score
    molecule
    role
    expression pathway
    chromatin immunoprecipitation
    protein-protein interaction
    URI
    https://hdl.handle.net/20.500.12503/29478
    Collections
    • School of Biomedical Sciences
    • Theses and Dissertations

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