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    Influence of the Carotid Baroreflex on Cerebral Blood Flow During Seated Upright Rest

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    Eubank_InfluenceOfTheCarotid.pdf (10.77Mb)
    Date
    2007-07-01
    Author
    Eubank, Wendy L.
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    Abstract
    Eubank, Wendy L., Influence of Carotid Baroreflex on Cerebral Blood Flow During Seated Upright Rest. Master of Science (Integrative Physiology), July, 2007, 25 pp., 1 table, 4 illustrations, 34 references. This study tested the hypothesis that sympathetic activation via the carotid baroreflex directly influences cerebral vasomotion during seated upright test. This study also examined the effects of pulsatile neck pressure (NP) and neck suction (NS) during seated upright rest in healthy human subjects. Changes in mean arterial pressure (MAP) and mean middle cerebral arterial velocity (MCA V mean), were measured. The power spectral density (PSD) of MAP of 0.1Hz increased during pulsatile NP and NS. The PSD of MCA V mean at 0.1Hz was much greater during NP than that of NS. There were no significant differences between end-tidal CO2 between each condition. These findings suggest that cerebral vasoconstriction during NP was a result of the autoregulatory response to the NP mediated pulsatile changes in arterial pressure and the NP induced sympathetically mediated vasoconstriction.
    Subject
    Cardiovascular System
    Life Sciences
    Medicine and Health Sciences
    Nervous System
    Physiology
    Systems and Integrative Physiology
    Carotid Baroreflex
    cerebral blood flow
    seated upright rest
    integrative physiology
    cerebral vasomotion
    pulsative neck pressure
    neck suction
    mean arterial pressure
    mean middle cerebral arterial velocity
    power spectral density
    autoregulatory
    sympathetically mediated vasoconstriction
    URI
    https://hdl.handle.net/20.500.12503/29586
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    • School of Biomedical Sciences
    • Theses and Dissertations

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