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dc.contributor.advisorNeeraj Agarwal
dc.creatorMarshall, Pamela L.
dc.date.accessioned2019-08-22T21:50:45Z
dc.date.available2019-08-22T21:50:45Z
dc.date.issued2001-05-01T00:00:00-07:00
dc.date.submitted2014-02-24T14:54:05-08:00
dc.identifier.urihttps://hdl.handle.net/20.500.12503/29624
dc.description.abstractMarshall, Pamela L., Alzheimer’s Fibroblasts Are More Susceptible to Oxidative Stress. Master’s of Science (Biomedical Sciences). May 2001. Recent evidence indicates that oxidative stress contributes to neuronal death in Alzheimer’s disease (AD). In addition, it has been suggested that AD is a systemic illness in which the development of the disease is only visible in the brain. The aim of this research is to develop experimental procedures using a simple cell model, the fibroblast, to determine if proteins derived from AD skin fibroblasts are more sensitive to oxidation by reactive oxygen species than non-AD cells, and to assess the ability of antioxidants to prevent this oxidative damage in AD fibroblasts. Preliminary findings suggest that changes in sensitivity are already detectable in fibroblasts from AD patients, probably as a consequence of genetic component as well as other risk factors. Therefore, this biochemical marker might have the potential for identifying individuals at risk for AD.
dc.format.mimetypeapplication/pdf
dc.language.isoen
dc.subjectCell Anatomy
dc.subjectCell and Developmental Biology
dc.subjectCell Biology
dc.subjectCells
dc.subjectDevelopmental Biology
dc.subjectDiagnosis
dc.subjectDisease Modeling
dc.subjectInvestigative Techniques
dc.subjectLife Sciences
dc.subjectMedical Cell Biology
dc.subjectMedical Neurobiology
dc.subjectMedicine and Health Sciences
dc.subjectMolecular and Cellular Neuroscience
dc.subjectNeuroscience and Neurobiology
dc.subjectOther Cell and Developmental Biology
dc.subjectAlzheimer’s Disease
dc.subjectFibroblasts
dc.subjectoxidative stress
dc.subjectneuronal death
dc.subjectcell model
dc.subjectoxidation
dc.subjectantioxidants
dc.subjectoxidative damage
dc.subjectrisk
dc.subjectbiochemical marker
dc.titleAlzheimer's Fibroblasts are More Susceptible to Oxidative Stress
dc.typeThesis
thesis.degree.departmentGraduate School of Biomedical Sciences
thesis.degree.disciplineBiomedical Sciences
thesis.degree.grantorUniversity of North Texas Health Science Center at Fort Worth
thesis.degree.nameMaster of Science
dc.contributor.committeeMemberRobert Gracy
dc.type.materialtext
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