Beneficial effects of dietary methionine restriction in aging and disease

Abstract

Purpose: Methionine is an essential amino acid, meaning the body cannot synthesize it de novo. It must be obtained in the diet. Methionine plays a role in many biochemical processes but is most well-known for its role in DNA methylation. Although methionine is classified as an essential amino acid, recent studies have suggested that methionine excess may contribute to cancer, shortened lifespans, and other undesirable conditions. As such, investigators have hypothesized the benefits of methionine restriction. In this poster presentation, we will outline the various benefits of methionine restriction and the mechanism by which these benefits manifest. Methods: We searched PubMed with the keywords "methionine restriction," then analyzed articles pertaining to the usage of methionine restriction in disease prevention or treatment. Results: Methionine restriction has several benefits in animal and human models. These benefits include improved skeletal muscle and metabolic health, prolonged cognitive health, improved gut microbiome, reduced cancer growth, reduced reperfusion-induced myocardial injury, prolonged life expectancy, etc. Conclusion: As research into methionine restriction grows, methionine restricted diets may be adopted as a health maintenance strategy or as adjunctive targeted therapy for cancer treatment, treatment of cognitive disorders, disorders of metabolic health, etc.