Now showing items 1-20 of 20

    • A Precision Medicine Approach to Treating Alzheimer's Disease Using Rosiglitazone Therapy: A Biomarker Analysis of the REFLECT Trials 

      O'Bryant, Sid E.; Zhang, Fan; Petersen, Melissa E.; Johnson, Leigh A.; Hall, James R.; Rissman, Robert A.; 0000-0003-0582-5266 (O'Bryant, Sid E.); 0000-0001-7769-8417 (Johnson, Leigh A.); 0000-0002-3920-5877 (Petersen, Melissa E.) (IOS Press, 2021-05-18)
      Background: The REFLECT trials were conducted to examine the treatment of mild-to-moderate Alzheimer's disease utilizing a peroxisome proliferator-activated receptor gamma agonist. Objective: To generate a predictive ...
    • A proteomic signature for dementia with Lewy bodies 

      O'Bryant, Sid E.; Ferman, Tanis J.; Zhang, Fan; Hall, James R.; Pedraza, Otto; Wszolek, Zbigniew K.; Como, Tori; Julovich, David A.; Mattevada, Sravan; Johnson, Leigh A.; Edwards, Melissa; Graff-Radford, Neill R.; 0000-0003-0582-5266 (O'Bryant, Sid E.); 0000-0001-7769-8417 (Johnson, Leigh A.) (Elsevier Inc., 2019-03-15)
      Introduction: We sought to determine if a proteomic profile approach developed to detect Alzheimer's disease would distinguish patients with Lewy body disease from normal controls, and if it would distinguish dementia with ...
    • Accelerating Hyperparameter Tuning in Machine Learning for Alzheimer's Disease With High Performance Computing 

      Zhang, Fan; Petersen, Melissa E.; Johnson, Leigh A.; Hall, James R.; O'Bryant, Sid E.; 0000-0003-0582-5266 (O'Bryant, Sid E.); 0000-0001-7769-8417 (Johnson, Leigh A.); 0000-0002-3920-5877 (Petersen, Melissa E.) (Frontiers Media S.A., 2021-12-08)
      Driven by massive datasets that comprise biomarkers from both blood and magnetic resonance imaging (MRI), the need for advanced learning algorithms and accelerator architectures, such as GPUs and FPGAs has increased. Machine ...
    • Acute Regression in Down Syndrome 

      Handen, Benjamin; Clare, Isabel; Laymon, Charles; Petersen, Melissa E.; Zaman, Shahid; O'Bryant, Sid E.; Minhas, Davneet; Tudorascu, Dana; Brown, Stephanie; Christian, Bradley; 0000-0003-0582-5266 (O'Bryant, Sid E.); 0000-0002-3920-5877 (Petersen, Melissa E.) (MDPI, 2021-08-23)
      Acute regression has been reported in some individuals with Down syndrome (DS), typically occurring between the teenage years and mid to late 20s. Characterized by sudden, and often unexplained, reductions in language ...
    • ApoE Genotype-Dependent Response to Antioxidant and Exercise Interventions on Brain Function 

      Chaudhari, Kiran; Wong, Jessica M.; Vann, Philip H.; Como, Tori; O'Bryant, Sid E.; Sumien, Nathalie; 0000-0003-0582-5266 (O'Bryant, Sid E.); 0000-0002-0077-9873 (Sumien, Nathalie) (MDPI, 2020-06-25)
      This study determined whether antioxidant supplementation is a viable complement to exercise regimens in improving cognitive and motor performance in a mouse model of Alzheimer's disease risk. Starting at 12 months of age, ...
    • Cardiovascular Risk Factors, Cognitive Dysfunction, and Mild Cognitive Impairment 

      Vintimilla, Raul; Balasubramanian, Kishore; Hall, James R.; Johnson, Leigh A.; O'Bryant, Sid E.; 0000-0003-0582-5266 (O'Bryant, Sid E.); 0000-0001-7769-8417 (Johnson, Leigh A.) (S. Karger AG, 2020-11-16)
      Objectives: The present study sought to evaluate the contribution of cardiovascular risk factors to cognitive functioning in a sample of Mexican Americans diagnosed with mild cognitive impairment (MCI). Methods: Hypertension, ...
    • Cerebrospinal fluid and blood biomarkers for neurodegenerative dementias: An update of the Consensus of the Task Force on Biological Markers in Psychiatry of the World Federation of Societies of Biological Psychiatry 

      Lewczuk, Piotr; Riederer, Peter; O'Bryant, Sid E.; Verbeek, Marcel M.; Dubois, Bruno; Visser, Pieter Jelle; Jellinger, Kurt A.; Engelborghs, Sebastiaan; Ramirez, Alfredo; Parnetti, Lucilla; Jack, Clifford R.; Teunissen, Charlotte E.; Hampel, Harald; Lleó, Alberto; Jessen, Frank; Glodzik, Lidia; de Leon, Mony J.; Fagan, Anne M.; Molinuevo, José Luis; Jansen, Willemijn J.; Winblad, Bengt; Shaw, Leslie M.; Andreasson, Ulf; Otto, Markus; Mollenhauer, Brit; Wiltfang, Jens; Turner, Martin R.; Zerr, Inga; Handels, Ron; Thompson, Alexander G.; Johansson, Gunilla; Ermann, Natalia; Trojanowski, John Q.; Karaca, Ilker; Wagner, Holger; Oeckl, Patrick; van Waalwijk van Doorn, Linda; Bjerke, Maria; Kapogiannis, Dimitrios; Kuiperij, H. Bea; Farotti, Lucia; Li, Yi; Gordon, Brian A.; Epelbaum, Stéphane; Vos, Stephanie J.B.; Klijn, Catharina J.M.; Van Nostrand, William E.; Minguillon, Carolina; Schmitz, Matthias; Gallo, Carla; Lopez Mato, Andrea; Thibaut, Florence; Lista, Simone; Alcolea, Daniel; Zetterberg, Henrik; Blennow, Kaj; Kornhuber, Johannes; 0000-0003-0582-5266 (O'Bryant, Sid E.) (Informa UK Limited, trading as Taylor & Francis Group, 2017-10-27)
      In the 12 years since the publication of the first Consensus Paper of the WFSBP on biomarkers of neurodegenerative dementias, enormous advancement has taken place in the field, and the Task Force takes now the opportunity ...
    • Characterization of the Meal-Stimulated Incretin Response and Relationship With Structural Brain Outcomes in Aging and Alzheimer's Disease 

      Morris, Jill K.; John, Casey S.; Green, Zachary D.; Wilkins, Heather M.; Wang, Xiaowan; Kamat, Ashwini; Swerdlow, Russell S.; Vidoni, Eric D.; Petersen, Melissa E.; O'Bryant, Sid E.; Honea, Robyn A.; Burns, Jeffrey M.; 0000-0003-0582-5266 (O'Bryant, Sid E.); 0000-0002-3920-5877 (Petersen, Melissa E.) (Frontiers Media S.A., 2020-11-30)
      Background: Individuals with Alzheimer's Disease (AD) are often characterized by systemic markers of insulin resistance; however, the broader effects of AD on other relevant metabolic hormones, such as incretins that affect ...
    • Circulating mitochondrial DNA: New indices of type 2 diabetes-related cognitive impairment in Mexican Americans 

      Silzer, Talisa; Barber, Robert C.; Sun, Jie; Pathak, Gita; Johnson, Leigh A.; O'Bryant, Sid E.; Phillips, Nicole; 0000-0001-6857-0286 (Barber, Robert C.); 0000-0003-0582-5266 (O'Bryant, Sid E.); 0000-0001-7769-8417 (Johnson, Leigh A.) (PLoS, 2019-03-12)
      Mitochondrial function has been implicated and studied in numerous complex age-related diseases. Understanding the potential role of mitochondria in disease pathophysiology is of importance due to the rise in prevalence ...
    • Current state of Alzheimer's fluid biomarkers 

      Molinuevo, José Luis; Ayton, Scott; Batrla, Richard; Bednar, Martin M.; Bittner, Tobias; Cummings, Jeffrey; Fagan, Anne M.; Hampel, Harald; Mielke, Michelle M.; Mikulskis, Alvydas; O'Bryant, Sid E.; Scheltens, Philip; Sevigny, Jeffrey; Shaw, Leslie M.; Soares, Holly D.; Tong, Gary; Trojanowski, John Q.; Zetterberg, Henrik; Blennow, Kaj; 0000-0003-0582-5266 (O'Bryant, Sid E.) (Springer, 2018-11-28)
      Alzheimer's disease (AD) is a progressive neurodegenerative disease with a complex and heterogeneous pathophysiology. The number of people living with AD is predicted to increase; however, there are no disease-modifying ...
    • Depression, inflammation, and memory loss among Mexican Americans: analysis of the HABLE cohort 

      Johnson, Leigh A.; Edwards, Melissa; Gamboa, Adriana; Hall, James R.; Robinson, Michelle; O'Bryant, Sid E.; 0000-0003-0582-5266 (O'Bryant, Sid E.); 0000-0001-7769-8417 (Johnson, Leigh A.) (Cambridge University Press, 2017-06-20)
      Background: This study explored the combined impact of depression and inflammation on memory functioning among Mexican-American adults and elders. Methods: Data were analyzed from 381 participants of the Health and Aging ...
    • MRI biomarkers of small vessel disease and cognition: A cross-sectional study of a cognitively normal Mexican American cohort 

      Vintimilla, Raul; Hall, James R.; King, Kevin; Braskie, Meredith N.; Johnson, Leigh A.; Yaffe, Kristine; Toga, Arthur W.; O'Bryant, Sid E.; 0000-0003-0582-5266 (O'Bryant, Sid E.); 0000-0001-7769-8417 (Johnson, Leigh A.) (Wiley Periodicals, LLC, 2021-10-14)
      Background: The current project sought to evaluate the impact that white matter hyperintensities (WMH) have on executive function in cognitively normal Mexican Americans, an underserved population with onset and more rapid ...
    • Neurodegeneration from the AT(N) framework is different among Mexican Americans compared to non-Hispanic Whites: A Health & Aging Brain among Latino Elders (HABLE) Study 

      O'Bryant, Sid E.; Zhang, Fan; Petersen, Melissa E.; Hall, James R.; Johnson, Leigh A.; Yaffe, Kristine; Braskie, Meredith N.; Rissman, Robert A.; Vig, Rocky; Toga, Arthur W.; 0000-0003-0582-5266 (O'Bryant, Sid E.); 0000-0001-7769-8417 (Johnson, Leigh A.); 0000-0002-3920-5877 (Petersen, Melissa E.) (Wiley Periodicals, LLC, 2022-02-09)
      Introduction: We sought to examine a magnetic resonance imaging (MRI)-based marker of neurodegeneration from the AT(N) (amyloid/tau/neurodegeneration) framework among a multi-ethnic, community-dwelling cohort. Methods: ...
    • Plasma Total Tau and Neurobehavioral Symptoms of Cognitive Decline in Cognitively Normal Older Adults 

      Hall, James R.; Petersen, Melissa E.; Johnson, Leigh A.; O'Bryant, Sid E.; 0000-0003-0582-5266 (O'Bryant, Sid E.); 0000-0001-7769-8417 (Johnson, Leigh A.); 0000-0002-3920-5877 (Petersen, Melissa E.) (Frontiers Media S.A., 2021-11-05)
      Depression and related neurobehavioral symptoms are common features of Alzheimer's disease and other dementias. The presence of these potentially modifiable neurobehavioral symptoms in cognitively intact older adults may ...
    • Potential two-step proteomic signature for Parkinson's disease: Pilot analysis in the Harvard Biomarkers Study 

      O'Bryant, Sid E.; Edwards, Melissa; Zhang, Fan; Johnson, Leigh A.; Hall, James R.; Kuras, Yuliya; Scherzer, Clemens R.; 0000-0003-0582-5266 (O'Bryant, Sid E.); 0000-0001-7769-8417 (Johnson, Leigh A.) (Elsevier Inc., 2019-05-02)
      Introduction: We sought to determine if our previously validated proteomic profile for detecting Alzheimer's disease would detect Parkinson's disease (PD) and distinguish PD from other neurodegenerative diseases. Methods: ...
    • Proteomic profiles for Alzheimer's disease and mild cognitive impairment among adults with Down syndrome spanning serum and plasma: An Alzheimer's Biomarker Consortium-Down Syndrome (ABC-DS) study 

      Petersen, Melissa E.; Zhang, Fan; Schupf, Nicole; Krinsky-McHale, Sharon J.; Hall, James R.; Mapstone, Mark; Cheema, Amrita; Silverman, Wayne; Lott, Ira; Rafii, Michael S.; Handen, Benjamin; Klunk, William; Head, Elizabeth; Christian, Bradley; Foroud, Tatiana; Lai, Florence; Rosas, H. Diana; Zaman, Shahid; Ances, Beau M.; Wang, Mei-Cheng; Tycko, Benjamin; Lee, Joseph H.; O'Bryant, Sid E.; 0000-0003-0582-5266 (O'Bryant, Sid E.); 0000-0002-3920-5877 (Petersen, Melissa E.) (Wiley Periodicals, Inc., 2020-06-30)
      Introduction: Previously generated serum and plasma proteomic profiles were examined among adults with Down syndrome (DS) to determine whether these profiles could discriminate those with mild cognitive impairment (MCI-DS) ...
    • Proteomic profiles of incident mild cognitive impairment and Alzheimer's disease among adults with Down syndrome 

      O'Bryant, Sid E.; Zhang, Fan; Silverman, Wayne; Lee, Joseph H.; Krinsky-McHale, Sharon J.; Pang, Deborah; Hall, James R.; Schupf, Nicole; 0000-0003-0582-5266 (O'Bryant, Sid E.) (Wiley Periodicals, Inc., 2020-05-21)
      Introduction: We sought to determine if proteomic profiles could predict risk for incident mild cognitive impairment (MCI) and Alzheimer's disease (AD) among adults with Down syndrome (DS). Methods: In a cohort of 398 ...
    • Proteomic profiles of prevalent mild cognitive impairment and Alzheimer's disease among adults with Down syndrome 

      Petersen, Melissa E.; Zhang, Fan; Krinsky-McHale, Sharon J.; Silverman, Wayne; Lee, Joseph H.; Pang, Deborah; Hall, James R.; Schupf, Nicole; O'Bryant, Sid E.; 0000-0003-0582-5266 (O'Bryant, Sid E.); 0000-0002-3920-5877 (Petersen, Melissa E.) (Wiley Periodicals, Inc., 2020-04-17)
      Introduction: We sought to determine if a proteomic profile approach developed to detect Alzheimer's disease (AD) in the general population would apply to adults with Down syndrome (DS). Methods: Plasma samples were ...
    • The Health & Aging Brain among Latino Elders (HABLE) study methods and participant characteristics 

      O'Bryant, Sid E.; Johnson, Leigh A.; Barber, Robert C.; Braskie, Meredith N.; Christian, Bradley; Hall, James R.; Hazra, Nalini; King, Kevin; Kothapalli, Deydeep; Large, Stephanie; Mason, David; Matsiyevskiy, Elizabeth; McColl, Roderick; Nandy, Rajesh; Palmer, Raymond; Petersen, Melissa E.; Philips, Nicole; Rissman, Robert A.; Shi, Yonggang; Toga, Arthur W.; Vintimilla, Raul; Vig, Rocky; Zhang, Fan; Yaffe, Kristine; 0000-0001-6857-0286 (Barber, Robert C.); 0000-0003-0582-5266 O'Bryant, Sid E.; 0000-0001-7769-8417 (Johnson, Leigh A.); 0000-0002-3920-5877 (Petersen, Melissa E.) (Wiley Periodicals, LLC, 2021-06-21)
      Introduction: Mexican Americans remain severely underrepresented in Alzheimer's disease (AD) research. The Health & Aging Brain among Latino Elders (HABLE) study was created to fill important gaps in the existing literature. ...
    • Water T2 as an early, global and practical biomarker for metabolic syndrome: an observational cross-sectional study 

      Robinson, Michelle D.; Mishra, Ina; Deodhar, Sneha; Patel, Vipulkumar; Gordon, Katrina V.; Vintimilla, Raul; Brown, Kim; Johnson, Leigh A.; O'Bryant, Sid E.; Cistola, David P.; 0000-0003-0582-5266 (O'Bryant, Sid); 0000-0001-7769-8417 (Johnson, Leigh A.) (BioMed Central Ltd., 2017-12-19)
      BACKGROUND: Metabolic syndrome (MetS) is a highly prevalent condition that identifies individuals at risk for type 2 diabetes mellitus and atherosclerotic cardiovascular disease. Prevention of these diseases relies on early ...