This collection is limited to articles published under the terms of a creative commons license or other open access publishing agreement since 2016. It is not intended as a complete list of the author's works.

Recent Submissions

  • MRI biomarkers of small vessel disease and cognition: A cross-sectional study of a cognitively normal Mexican American cohort 

    Vintimilla, Raul; Hall, James R.; King, Kevin; Braskie, Meredith N.; Johnson, Leigh A.; Yaffe, Kristine; Toga, Arthur W.; O'Bryant, Sid E.; 0000-0003-0582-5266 (O'Bryant, Sid E.); 0000-0001-7769-8417 (Johnson, Leigh A.) (Wiley Periodicals, LLC, 2021-10-14)
    Background: The current project sought to evaluate the impact that white matter hyperintensities (WMH) have on executive function in cognitively normal Mexican Americans, an underserved population with onset and more rapid ...
  • Proteomic profiles of prevalent mild cognitive impairment and Alzheimer's disease among adults with Down syndrome 

    Petersen, Melissa E.; Zhang, Fan; Krinsky-McHale, Sharon J.; Silverman, Wayne; Lee, Joseph H.; Pang, Deborah; Hall, James R.; Schupf, Nicole; O'Bryant, Sid E.; 0000-0003-0582-5266 (O'Bryant, Sid E.); 0000-0002-3920-5877 (Petersen, Melissa E.) (Wiley Periodicals, Inc., 2020-04-17)
    Introduction: We sought to determine if a proteomic profile approach developed to detect Alzheimer's disease (AD) in the general population would apply to adults with Down syndrome (DS). Methods: Plasma samples were ...
  • Proteomic profiles for Alzheimer's disease and mild cognitive impairment among adults with Down syndrome spanning serum and plasma: An Alzheimer's Biomarker Consortium-Down Syndrome (ABC-DS) study 

    Petersen, Melissa E.; Zhang, Fan; Schupf, Nicole; Krinsky-McHale, Sharon J.; Hall, James R.; Mapstone, Mark; Cheema, Amrita; Silverman, Wayne; Lott, Ira; Rafii, Michael S.; Handen, Benjamin; Klunk, William; Head, Elizabeth; Christian, Bradley; Foroud, Tatiana; Lai, Florence; Rosas, H. Diana; Zaman, Shahid; Ances, Beau M.; Wang, Mei-Cheng; Tycko, Benjamin; Lee, Joseph H.; O'Bryant, Sid E.; 0000-0003-0582-5266 (O'Bryant, Sid E.); 0000-0002-3920-5877 (Petersen, Melissa E.) (Wiley Periodicals, Inc., 2020-06-30)
    Introduction: Previously generated serum and plasma proteomic profiles were examined among adults with Down syndrome (DS) to determine whether these profiles could discriminate those with mild cognitive impairment (MCI-DS) ...
  • Cardiovascular Risk Factors, Cognitive Dysfunction, and Mild Cognitive Impairment 

    Vintimilla, Raul; Balasubramanian, Kishore; Hall, James R.; Johnson, Leigh A.; O'Bryant, Sid E.; 0000-0003-0582-5266 (O'Bryant, Sid E.); 0000-0001-7769-8417 (Johnson, Leigh A.) (S. Karger AG, 2020-11-16)
    Objectives: The present study sought to evaluate the contribution of cardiovascular risk factors to cognitive functioning in a sample of Mexican Americans diagnosed with mild cognitive impairment (MCI). Methods: Hypertension, ...
  • Accelerating Hyperparameter Tuning in Machine Learning for Alzheimer's Disease With High Performance Computing 

    Zhang, Fan; Petersen, Melissa E.; Johnson, Leigh A.; Hall, James R.; O'Bryant, Sid E.; 0000-0003-0582-5266 (O'Bryant, Sid E.); 0000-0001-7769-8417 (Johnson, Leigh A.); 0000-0002-3920-5877 (Petersen, Melissa E.) (Frontiers Media S.A., 2021-12-08)
    Driven by massive datasets that comprise biomarkers from both blood and magnetic resonance imaging (MRI), the need for advanced learning algorithms and accelerator architectures, such as GPUs and FPGAs has increased. Machine ...
  • Proteomic profiles of incident mild cognitive impairment and Alzheimer's disease among adults with Down syndrome 

    O'Bryant, Sid E.; Zhang, Fan; Silverman, Wayne; Lee, Joseph H.; Krinsky-McHale, Sharon J.; Pang, Deborah; Hall, James R.; Schupf, Nicole; 0000-0003-0582-5266 (O'Bryant, Sid E.) (Wiley Periodicals, Inc., 2020-05-21)
    Introduction: We sought to determine if proteomic profiles could predict risk for incident mild cognitive impairment (MCI) and Alzheimer's disease (AD) among adults with Down syndrome (DS). Methods: In a cohort of 398 ...
  • Neurodegeneration from the AT(N) framework is different among Mexican Americans compared to non-Hispanic Whites: A Health & Aging Brain among Latino Elders (HABLE) Study 

    O'Bryant, Sid E.; Zhang, Fan; Petersen, Melissa E.; Hall, James R.; Johnson, Leigh A.; Yaffe, Kristine; Braskie, Meredith N.; Rissman, Robert A.; Vig, Rocky; Toga, Arthur W.; 0000-0003-0582-5266 (O'Bryant, Sid E.); 0000-0001-7769-8417 (Johnson, Leigh A.); 0000-0002-3920-5877 (Petersen, Melissa E.) (Wiley Periodicals, LLC, 2022-02-09)
    Introduction: We sought to examine a magnetic resonance imaging (MRI)-based marker of neurodegeneration from the AT(N) (amyloid/tau/neurodegeneration) framework among a multi-ethnic, community-dwelling cohort. Methods: ...
  • A Precision Medicine Approach to Treating Alzheimer's Disease Using Rosiglitazone Therapy: A Biomarker Analysis of the REFLECT Trials 

    O'Bryant, Sid E.; Zhang, Fan; Petersen, Melissa E.; Johnson, Leigh A.; Hall, James R.; Rissman, Robert A.; 0000-0003-0582-5266 (O'Bryant, Sid E.); 0000-0001-7769-8417 (Johnson, Leigh A.); 0000-0002-3920-5877 (Petersen, Melissa E.) (IOS Press, 2021-05-18)
    Background: The REFLECT trials were conducted to examine the treatment of mild-to-moderate Alzheimer's disease utilizing a peroxisome proliferator-activated receptor gamma agonist. Objective: To generate a predictive ...
  • Potential two-step proteomic signature for Parkinson's disease: Pilot analysis in the Harvard Biomarkers Study 

    O'Bryant, Sid E.; Edwards, Melissa; Zhang, Fan; Johnson, Leigh A.; Hall, James R.; Kuras, Yuliya; Scherzer, Clemens R.; 0000-0003-0582-5266 (O'Bryant, Sid E.); 0000-0001-7769-8417 (Johnson, Leigh A.) (Elsevier Inc., 2019-05-02)
    Introduction: We sought to determine if our previously validated proteomic profile for detecting Alzheimer's disease would detect Parkinson's disease (PD) and distinguish PD from other neurodegenerative diseases. Methods: ...
  • A proteomic signature for dementia with Lewy bodies 

    O'Bryant, Sid E.; Ferman, Tanis J.; Zhang, Fan; Hall, James R.; Pedraza, Otto; Wszolek, Zbigniew K.; Como, Tori; Julovich, David A.; Mattevada, Sravan; Johnson, Leigh A.; Edwards, Melissa; Graff-Radford, Neill R.; 0000-0003-0582-5266 (O'Bryant, Sid E.); 0000-0001-7769-8417 (Johnson, Leigh A.) (Elsevier Inc., 2019-03-15)
    Introduction: We sought to determine if a proteomic profile approach developed to detect Alzheimer's disease would distinguish patients with Lewy body disease from normal controls, and if it would distinguish dementia with ...
  • Depression, inflammation, and memory loss among Mexican Americans: analysis of the HABLE cohort 

    Johnson, Leigh A.; Edwards, Melissa; Gamboa, Adriana; Hall, James R.; Robinson, Michelle; O'Bryant, Sid E.; 0000-0003-0582-5266 (O'Bryant, Sid E.); 0000-0001-7769-8417 (Johnson, Leigh A.) (Cambridge University Press, 2017-06-20)
    Background: This study explored the combined impact of depression and inflammation on memory functioning among Mexican-American adults and elders. Methods: Data were analyzed from 381 participants of the Health and Aging ...
  • Plasma Total Tau and Neurobehavioral Symptoms of Cognitive Decline in Cognitively Normal Older Adults 

    Hall, James R.; Petersen, Melissa E.; Johnson, Leigh A.; O'Bryant, Sid E.; 0000-0003-0582-5266 (O'Bryant, Sid E.); 0000-0001-7769-8417 (Johnson, Leigh A.); 0000-0002-3920-5877 (Petersen, Melissa E.) (Frontiers Media S.A., 2021-11-05)
    Depression and related neurobehavioral symptoms are common features of Alzheimer's disease and other dementias. The presence of these potentially modifiable neurobehavioral symptoms in cognitively intact older adults may ...
  • The Health & Aging Brain among Latino Elders (HABLE) study methods and participant characteristics 

    O'Bryant, Sid E.; Johnson, Leigh A.; Barber, Robert C.; Braskie, Meredith N.; Christian, Bradley; Hall, James R.; Hazra, Nalini; King, Kevin; Kothapalli, Deydeep; Large, Stephanie; Mason, David; Matsiyevskiy, Elizabeth; McColl, Roderick; Nandy, Rajesh; Palmer, Raymond; Petersen, Melissa E.; Philips, Nicole; Rissman, Robert A.; Shi, Yonggang; Toga, Arthur W.; Vintimilla, Raul; Vig, Rocky; Zhang, Fan; Yaffe, Kristine; 0000-0001-6857-0286 (Barber, Robert C.); 0000-0003-0582-5266 O'Bryant, Sid E.; 0000-0001-7769-8417 (Johnson, Leigh A.); 0000-0002-3920-5877 (Petersen, Melissa E.) (Wiley Periodicals, LLC, 2021-06-21)
    Introduction: Mexican Americans remain severely underrepresented in Alzheimer's disease (AD) research. The Health & Aging Brain among Latino Elders (HABLE) study was created to fill important gaps in the existing literature. ...