This collection is limited to articles published under the terms of a creative commons license or other open access publishing agreement since 2016. It is not intended as a complete list of the author's works.

Recent Submissions

  • Proteomic profiles of prevalent mild cognitive impairment and Alzheimer's disease among adults with Down syndrome 

    Petersen, Melissa E.; Zhang, Fan; Krinsky-McHale, Sharon J.; Silverman, Wayne; Lee, Joseph H.; Pang, Deborah; Hall, James R.; Schupf, Nicole; O'Bryant, Sid E.; 0000-0003-0582-5266 (O'Bryant, Sid E.); 0000-0002-3920-5877 (Petersen, Melissa E.) (Wiley Periodicals, Inc., 2020-04-17)
    Introduction: We sought to determine if a proteomic profile approach developed to detect Alzheimer's disease (AD) in the general population would apply to adults with Down syndrome (DS). Methods: Plasma samples were ...
  • Proteomic profiles for Alzheimer's disease and mild cognitive impairment among adults with Down syndrome spanning serum and plasma: An Alzheimer's Biomarker Consortium-Down Syndrome (ABC-DS) study 

    Petersen, Melissa E.; Zhang, Fan; Schupf, Nicole; Krinsky-McHale, Sharon J.; Hall, James R.; Mapstone, Mark; Cheema, Amrita; Silverman, Wayne; Lott, Ira; Rafii, Michael S.; Handen, Benjamin; Klunk, William; Head, Elizabeth; Christian, Bradley; Foroud, Tatiana; Lai, Florence; Rosas, H. Diana; Zaman, Shahid; Ances, Beau M.; Wang, Mei-Cheng; Tycko, Benjamin; Lee, Joseph H.; O'Bryant, Sid E.; 0000-0003-0582-5266 (O'Bryant, Sid E.); 0000-0002-3920-5877 (Petersen, Melissa E.) (Wiley Periodicals, Inc., 2020-06-30)
    Introduction: Previously generated serum and plasma proteomic profiles were examined among adults with Down syndrome (DS) to determine whether these profiles could discriminate those with mild cognitive impairment (MCI-DS) ...
  • Accelerating Hyperparameter Tuning in Machine Learning for Alzheimer's Disease With High Performance Computing 

    Zhang, Fan; Petersen, Melissa E.; Johnson, Leigh A.; Hall, James R.; O'Bryant, Sid E.; 0000-0003-0582-5266 (O'Bryant, Sid E.); 0000-0001-7769-8417 (Johnson, Leigh A.); 0000-0002-3920-5877 (Petersen, Melissa E.) (Frontiers Media S.A., 2021-12-08)
    Driven by massive datasets that comprise biomarkers from both blood and magnetic resonance imaging (MRI), the need for advanced learning algorithms and accelerator architectures, such as GPUs and FPGAs has increased. Machine ...
  • Neurodegeneration from the AT(N) framework is different among Mexican Americans compared to non-Hispanic Whites: A Health & Aging Brain among Latino Elders (HABLE) Study 

    O'Bryant, Sid E.; Zhang, Fan; Petersen, Melissa E.; Hall, James R.; Johnson, Leigh A.; Yaffe, Kristine; Braskie, Meredith N.; Rissman, Robert A.; Vig, Rocky; Toga, Arthur W.; 0000-0003-0582-5266 (O'Bryant, Sid E.); 0000-0001-7769-8417 (Johnson, Leigh A.); 0000-0002-3920-5877 (Petersen, Melissa E.) (Wiley Periodicals, LLC, 2022-02-09)
    Introduction: We sought to examine a magnetic resonance imaging (MRI)-based marker of neurodegeneration from the AT(N) (amyloid/tau/neurodegeneration) framework among a multi-ethnic, community-dwelling cohort. Methods: ...
  • A Precision Medicine Approach to Treating Alzheimer's Disease Using Rosiglitazone Therapy: A Biomarker Analysis of the REFLECT Trials 

    O'Bryant, Sid E.; Zhang, Fan; Petersen, Melissa E.; Johnson, Leigh A.; Hall, James R.; Rissman, Robert A.; 0000-0003-0582-5266 (O'Bryant, Sid E.); 0000-0001-7769-8417 (Johnson, Leigh A.); 0000-0002-3920-5877 (Petersen, Melissa E.) (IOS Press, 2021-05-18)
    Background: The REFLECT trials were conducted to examine the treatment of mild-to-moderate Alzheimer's disease utilizing a peroxisome proliferator-activated receptor gamma agonist. Objective: To generate a predictive ...
  • Characterization of the Meal-Stimulated Incretin Response and Relationship With Structural Brain Outcomes in Aging and Alzheimer's Disease 

    Morris, Jill K.; John, Casey S.; Green, Zachary D.; Wilkins, Heather M.; Wang, Xiaowan; Kamat, Ashwini; Swerdlow, Russell S.; Vidoni, Eric D.; Petersen, Melissa E.; O'Bryant, Sid E.; Honea, Robyn A.; Burns, Jeffrey M.; 0000-0003-0582-5266 (O'Bryant, Sid E.); 0000-0002-3920-5877 (Petersen, Melissa E.) (Frontiers Media S.A., 2020-11-30)
    Background: Individuals with Alzheimer's Disease (AD) are often characterized by systemic markers of insulin resistance; however, the broader effects of AD on other relevant metabolic hormones, such as incretins that affect ...
  • Acute Regression in Down Syndrome 

    Handen, Benjamin; Clare, Isabel; Laymon, Charles; Petersen, Melissa E.; Zaman, Shahid; O'Bryant, Sid E.; Minhas, Davneet; Tudorascu, Dana; Brown, Stephanie; Christian, Bradley; 0000-0003-0582-5266 (O'Bryant, Sid E.); 0000-0002-3920-5877 (Petersen, Melissa E.) (MDPI, 2021-08-23)
    Acute regression has been reported in some individuals with Down syndrome (DS), typically occurring between the teenage years and mid to late 20s. Characterized by sudden, and often unexplained, reductions in language ...
  • Plasma Total Tau and Neurobehavioral Symptoms of Cognitive Decline in Cognitively Normal Older Adults 

    Hall, James R.; Petersen, Melissa E.; Johnson, Leigh A.; O'Bryant, Sid E.; 0000-0003-0582-5266 (O'Bryant, Sid E.); 0000-0001-7769-8417 (Johnson, Leigh A.); 0000-0002-3920-5877 (Petersen, Melissa E.) (Frontiers Media S.A., 2021-11-05)
    Depression and related neurobehavioral symptoms are common features of Alzheimer's disease and other dementias. The presence of these potentially modifiable neurobehavioral symptoms in cognitively intact older adults may ...
  • The Health & Aging Brain among Latino Elders (HABLE) study methods and participant characteristics 

    O'Bryant, Sid E.; Johnson, Leigh A.; Barber, Robert C.; Braskie, Meredith N.; Christian, Bradley; Hall, James R.; Hazra, Nalini; King, Kevin; Kothapalli, Deydeep; Large, Stephanie; Mason, David; Matsiyevskiy, Elizabeth; McColl, Roderick; Nandy, Rajesh; Palmer, Raymond; Petersen, Melissa E.; Philips, Nicole; Rissman, Robert A.; Shi, Yonggang; Toga, Arthur W.; Vintimilla, Raul; Vig, Rocky; Zhang, Fan; Yaffe, Kristine; 0000-0001-6857-0286 (Barber, Robert C.); 0000-0003-0582-5266 O'Bryant, Sid E.; 0000-0001-7769-8417 (Johnson, Leigh A.); 0000-0002-3920-5877 (Petersen, Melissa E.) (Wiley Periodicals, LLC, 2021-06-21)
    Introduction: Mexican Americans remain severely underrepresented in Alzheimer's disease (AD) research. The Health & Aging Brain among Latino Elders (HABLE) study was created to fill important gaps in the existing literature. ...