Member, Institute for Healthy Aging

Associate Professor, Pharmacology & Neuroscience


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  • Novel pharmacotherapy: NNI-362, an allosteric p70S6 kinase stimulator, reverses cognitive and neural regenerative deficits in models of aging and disease 

    Sumien, Nathalie; Wells, Matthew S.; Sidhu, Akram; Wong, Jessica M.; Forster, Michael J.; Zheng, Qiao-Xi; Kelleher-Andersson, Judith A.; 0000-0002-0077-9873 (Sumien, Nathalie) (BioMed Central Ltd., 2021-01-13)
    Aging is known to slow the neurogenic capacity of the hippocampus, one of only two mammalian adult neurogenic niches. The reduction of adult-born neurons with age may initiate cognitive decline progression which is exacerbated ...
  • Long-term HIV-1 Tat Expression in the Brain Led to Neurobehavioral, Pathological, and Epigenetic Changes Reminiscent of Accelerated Aging 

    Zhao, Xiaojie; Fan, Yan; Vann, Philip H.; Wong, Jessica M.; Sumien, Nathalie; He, Johnny J.; 0000-0002-0077-9873 (Sumien, Nathalie) (International Society on Aging and Disease, 2020-02-01)
    HIV infects the central nervous system and causes HIV/neuroAIDS, which is predominantly manifested in the form of mild cognitive and motor disorder in the era of combination antiretroviral therapy. HIV Tat protein is known ...
  • Pancreatic mitochondrial complex I exhibits aberrant hyperactivity in diabetes 

    Wu, Jinzi; Luo, Xiaoting; Thangthaeng, Nopporn; Sumien, Nathalie; Chen, Zhenglan; Rutledge, Margaret A.; Jing, Siqun; Forster, Michael J.; Yan, Liang-Jun; 0000-0002-0077-9873 (Sumien, Nathalie); 0000-0002-5815-5430 (Liang-Jun Yan) (Elsevier Inc., 2017-07-19)
    It is well established that NADH/NAD(+) redox balance is heavily perturbed in diabetes, and the NADH/NAD(+) redox imbalance is a major source of oxidative stress in diabetic tissues. In mitochondria, complex I is the only ...
  • Gait Analyses in Mice: Effects of Age and Glutathione Deficiency 

    Mock, J. Thomas; Knight, Sherilynn G.; Vann, Philip H.; Wong, Jessica M.; Davis, Delaney L.; Forster, Michael J.; Sumien, Nathalie; 0000-0002-0077-9873 (Sumien, Nathalie) (International Society on Aging and Disease, 2018-08-01)
    Minor changes (~0.1 m/s) in human gait speed are predictive of various measures of decline and can be used to identify at-risk individuals prior to further decline. These associations are possible due to an abundance of ...
  • Astrocyte HIV-1 Tat Differentially Modulates Behavior and Brain MMP/TIMP Balance During Short and Prolonged Induction in Transgenic Mice 

    Joshi, Chaitanya R.; Stacy, Satomi; Sumien, Nathalie; Ghorpade, Anuja; Borgmann, Kathleen; 0000-0002-0077-9873 (Sumien, Nathalie); 0000-0003-0897-390X (Borgmann, Kathleen) (Frontiers Media S.A., 2020-12-15)
    Despite effective antiretroviral therapy (ART), mild forms of HIV-associated neurocognitive disorders (HAND) continue to afflict approximately half of all people living with HIV (PLWH). As PLWH age, HIV-associated inflammation ...
  • Evaluation of Substituted N-Phenylpiperazine Analogs as D3 vs. D2 Dopamine Receptor Subtype Selective Ligands 

    Lee, Boeun; Taylor, Michelle; Griffin, Suzy A.; McInnis, Tamara; Sumien, Nathalie; Mach, Robert H.; Luedtke, Robert R.; 0000-0002-0077-9873 (Sumien, Nathalie) (MDPI, 2021-05-26)
    N-phenylpiperazine analogs can bind selectively to the D3 versus the D2 dopamine receptor subtype despite the fact that these two D2-like dopamine receptor subtypes exhibit substantial amino acid sequence homology. The ...
  • ApoE Genotype-Dependent Response to Antioxidant and Exercise Interventions on Brain Function 

    Chaudhari, Kiran; Wong, Jessica M.; Vann, Philip H.; Como, Tori; O'Bryant, Sid E.; Sumien, Nathalie; 0000-0003-0582-5266 (O'Bryant, Sid E.); 0000-0002-0077-9873 (Sumien, Nathalie) (MDPI, 2020-06-25)
    This study determined whether antioxidant supplementation is a viable complement to exercise regimens in improving cognitive and motor performance in a mouse model of Alzheimer's disease risk. Starting at 12 months of age, ...