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dc.rights.licenseAttribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)
dc.creatorLewczuk, Piotr
dc.creatorRiederer, Peter
dc.creatorO'Bryant, Sid E.
dc.creatorVerbeek, Marcel M.
dc.creatorDubois, Bruno
dc.creatorVisser, Pieter Jelle
dc.creatorJellinger, Kurt A.
dc.creatorEngelborghs, Sebastiaan
dc.creatorRamirez, Alfredo
dc.creatorParnetti, Lucilla
dc.creatorJack, Clifford R.
dc.creatorTeunissen, Charlotte E.
dc.creatorHampel, Harald
dc.creatorLleó, Alberto
dc.creatorJessen, Frank
dc.creatorGlodzik, Lidia
dc.creatorde Leon, Mony J.
dc.creatorFagan, Anne M.
dc.creatorMolinuevo, José Luis
dc.creatorJansen, Willemijn J.
dc.creatorWinblad, Bengt
dc.creatorShaw, Leslie M.
dc.creatorAndreasson, Ulf
dc.creatorOtto, Markus
dc.creatorMollenhauer, Brit
dc.creatorWiltfang, Jens
dc.creatorTurner, Martin R.
dc.creatorZerr, Inga
dc.creatorHandels, Ron
dc.creatorThompson, Alexander G.
dc.creatorJohansson, Gunilla
dc.creatorErmann, Natalia
dc.creatorTrojanowski, John Q.
dc.creatorKaraca, Ilker
dc.creatorWagner, Holger
dc.creatorOeckl, Patrick
dc.creatorvan Waalwijk van Doorn, Linda
dc.creatorBjerke, Maria
dc.creatorKapogiannis, Dimitrios
dc.creatorKuiperij, H. Bea
dc.creatorFarotti, Lucia
dc.creatorLi, Yi
dc.creatorGordon, Brian A.
dc.creatorEpelbaum, Stéphane
dc.creatorVos, Stephanie J.B.
dc.creatorKlijn, Catharina J.M.
dc.creatorVan Nostrand, William E.
dc.creatorMinguillon, Carolina
dc.creatorSchmitz, Matthias
dc.creatorGallo, Carla
dc.creatorLopez Mato, Andrea
dc.creatorThibaut, Florence
dc.creatorLista, Simone
dc.creatorAlcolea, Daniel
dc.creatorZetterberg, Henrik
dc.creatorBlennow, Kaj
dc.creatorKornhuber, Johannes
dc.date.accessioned2022-07-07T13:54:26Z
dc.date.available2022-07-07T13:54:26Z
dc.date.issued2017-10-27
dc.identifier.citationLewczuk, P., Riederer, P., O'Bryant, S. E., Verbeek, M. M., Dubois, B., Visser, P. J., Jellinger, K. A., Engelborghs, S., Ramirez, A., Parnetti, L., Jack, C. R., Jr, Teunissen, C. E., Hampel, H., Lleó, A., Jessen, F., Glodzik, L., de Leon, M. J., Fagan, A. M., Molinuevo, J. L., Jansen, W. J., Members of the WFSBP Task Force Working on this Topic: Peter Riederer, Carla Gallo, Dimitrios Kapogiannis, Andrea Lopez Mato, Florence Thibaut (2018). Cerebrospinal fluid and blood biomarkers for neurodegenerative dementias: An update of the Consensus of the Task Force on Biological Markers in Psychiatry of the World Federation of Societies of Biological Psychiatry. The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry, 19(4), 244-328. https://doi.org/10.1080/15622975.2017.1375556
dc.identifier.issn1814-1412
dc.identifier.urihttps://hdl.handle.net/20.500.12503/31533
dc.description.abstractIn the 12 years since the publication of the first Consensus Paper of the WFSBP on biomarkers of neurodegenerative dementias, enormous advancement has taken place in the field, and the Task Force takes now the opportunity to extend and update the original paper. New concepts of Alzheimer's disease (AD) and the conceptual interactions between AD and dementia due to AD were developed, resulting in two sets for diagnostic/research criteria. Procedures for pre-analytical sample handling, biobanking, analyses and post-analytical interpretation of the results were intensively studied and optimised. A global quality control project was introduced to evaluate and monitor the inter-centre variability in measurements with the goal of harmonisation of results. Contexts of use and how to approach candidate biomarkers in biological specimens other than cerebrospinal fluid (CSF), e.g. blood, were precisely defined. Important development was achieved in neuroimaging techniques, including studies comparing amyloid-β positron emission tomography results to fluid-based modalities. Similarly, development in research laboratory technologies, such as ultra-sensitive methods, raises our hopes to further improve analytical and diagnostic accuracy of classic and novel candidate biomarkers. Synergistically, advancement in clinical trials of anti-dementia therapies energises and motivates the efforts to find and optimise the most reliable early diagnostic modalities. Finally, the first studies were published addressing the potential of cost-effectiveness of the biomarkers-based diagnosis of neurodegenerative disorders.
dc.description.sponsorshipThis work was funded by Bundesministerium für Bildungund Forschung, Germany (BiomarkAPD [grant number01ED1203D]; Kompetenznetz Demenzen [grant number01GI0420]) and Innovative Medicines Initiative JointUndertaking [grant number EMIF 115372].
dc.publisherInforma UK Limited, trading as Taylor & Francis Group
dc.relation.urihttps://doi.org/10.1080/15622975.2017.1375556
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.sourceThe World Journal of Biological Psychiatry
dc.subjectAlzheimer's disease
dc.subject.meshAlzheimer Disease
dc.subject.meshBiological Psychiatry
dc.subject.meshBiomarkers
dc.subject.meshConsensus
dc.subject.meshDementia
dc.subject.meshHumans
dc.subject.meshNeurodegenerative Diseases
dc.subject.meshSocieties, Medical
dc.subject.meshCerebrospinal Fluid
dc.titleCerebrospinal fluid and blood biomarkers for neurodegenerative dementias: An update of the Consensus of the Task Force on Biological Markers in Psychiatry of the World Federation of Societies of Biological Psychiatry
dc.typeArticle
dc.rights.holder© 2017 The Author(s).
dc.type.materialtext
dc.creator.orcid0000-0003-0582-5266 (O'Bryant, Sid E.)
dc.identifier.volume19
dc.identifier.issue4


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Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)