Browsing Publications -- Kathleen Borgmann by Title
Now showing items 4-8 of 8
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Cal'MAM'ity at the Endoplasmic Reticulum-Mitochondrial Interface: A Potential Therapeutic Target for Neurodegeneration and Human Immunodeficiency Virus-Associated Neurocognitive Disorders
(Frontiers Media S.A., 2021-10-21)The endoplasmic reticulum (ER) is a multifunctional organelle and serves as the primary site for intracellular calcium storage, lipid biogenesis, protein synthesis, and quality control. Mitochondria are responsible for ... -
HIV-1-Mediated Acceleration of Oncovirus-Related Non-AIDS-Defining Cancers
(MDPI, 2022-03-25)With the advent of combination antiretroviral therapy (cART), overall survival has been improved, and the incidence of acquired immunodeficiency syndrome (AIDS)-defining cancers has also been remarkably reduced. However, ... -
Methamphetamine Activates Trace Amine Associated Receptor 1 to Regulate Astrocyte Excitatory Amino Acid Transporter-2 via Differential CREB Phosphorylation During HIV-Associated Neurocognitive Disorders
(Frontiers Media S.A., 2020-11-25)Methamphetamine (METH) use, referred to as methamphetamine use disorder (MUD), results in neurocognitive decline, a characteristic shared with HIV-associated neurocognitive disorders (HAND). MUD exacerbates HAND partly ... -
Role of Virally-Encoded Deubiquitinating Enzymes in Regulation of the Virus Life Cycle
(MDPI, 2021-04-23)The ubiquitin (Ub) proteasome system (UPS) plays a pivotal role in regulation of numerous cellular processes, including innate and adaptive immune responses that are essential for restriction of the virus life cycle in the ... -
β-Catenin Regulates Wound Healing and IL-6 Expression in Activated Human Astrocytes
(MDPI, 2020-11-06)Reactive astrogliosis is prominent in most neurodegenerative disorders and is often associated with neuroinflammation. The molecular mechanisms regulating astrocyte-linked neuropathogenesis during injury, aging and human ...