Publications -- InWoo Park
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This collection is limited to articles published under the terms of a creative commons license or other open access publishing agreement since 2016. It is not intended as a complete list of the author's works.
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Ubiquitin-protein ligase E3A (UBE3A) mediation of viral infection and human diseases
(Elsevier B.V., 2023-08-05)The Ubiquitin-protein ligase E3A, UBE3A, also known as E6-associated protein (E6-AP), is known to play an essential role in regulating the degradation of various proteins by transferring Ub from E2 Ub conjugating enzymes ... -
Novel role of HIV-1 Nef in regulating the ubiquitination of cellular proteins
(Frontiers Media S.A., 2023-03-28)Our recent data established that HIV-1 Nef is pivotal in determining the fate of cellular proteins by modulating ubiquitination. However, it is unknown which proteins are ubiquitinated in the presence of Nef, a question ... -
Signature molecules expressed differentially in a liver disease stage-specific manner by HIV-1 and HCV co-infection
(PLOS, 2018-08-23)To elucidate HIV-1 co-infection-induced acceleration of HCV liver disease and identify stage-specific molecular signatures, we applied a new high-resolution molecular screen, the Affymetrix GeneChip Human Transcriptome ... -
HIV-1 Impairment via UBE3A and HIV-1 Nef Interactions Utilizing the Ubiquitin Proteasome System
(MDPI, 2019-11-27)Molecular basis of HIV-1 life cycle regulation has thus far focused on viral gene stage-specificity, despite the quintessence of post-function protein elimination processes in the virus life cycle and consequent pathogenesis. ... -
The Many Faces of Innate Immunity in SARS-CoV-2 Infection
(MDPI, 2021-06-04)The innate immune system is important for initial antiviral response. SARS-CoV-2 can result in overactivity or suppression of the innate immune system. A dysregulated immune response is associated with poor outcomes; with ... -
Role of Virally-Encoded Deubiquitinating Enzymes in Regulation of the Virus Life Cycle
(MDPI, 2021-04-23)The ubiquitin (Ub) proteasome system (UPS) plays a pivotal role in regulation of numerous cellular processes, including innate and adaptive immune responses that are essential for restriction of the virus life cycle in the ... -
Cal'MAM'ity at the Endoplasmic Reticulum-Mitochondrial Interface: A Potential Therapeutic Target for Neurodegeneration and Human Immunodeficiency Virus-Associated Neurocognitive Disorders
(Frontiers Media S.A., 2021-10-21)The endoplasmic reticulum (ER) is a multifunctional organelle and serves as the primary site for intracellular calcium storage, lipid biogenesis, protein synthesis, and quality control. Mitochondria are responsible for ... -
HIV-1-Mediated Acceleration of Oncovirus-Related Non-AIDS-Defining Cancers
(MDPI, 2022-03-25)With the advent of combination antiretroviral therapy (cART), overall survival has been improved, and the incidence of acquired immunodeficiency syndrome (AIDS)-defining cancers has also been remarkably reduced. However, ...
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