HIV-1-Mediated Acceleration of Oncovirus-Related Non-AIDS-Defining Cancers

Date

2022-03-25

Authors

Proulx, Jessica
Ghaly, Maria
Park, InWoo
Borgmann, Kathleen

ORCID

0000-0003-0897-390X (Borgmann, Kathleen)
0000-0002-5452-0461 (Proulx, Jessica)

Journal Title

Journal ISSN

Volume Title

Publisher

MDPI

Abstract

With the advent of combination antiretroviral therapy (cART), overall survival has been improved, and the incidence of acquired immunodeficiency syndrome (AIDS)-defining cancers has also been remarkably reduced. However, non-AIDS-defining cancers among human immunodeficiency virus-1 (HIV-1)-associated malignancies have increased significantly so that cancer is the leading cause of death in people living with HIV in certain highly developed countries, such as France. However, it is currently unknown how HIV-1 infection raises oncogenic virus-mediated cancer risks in the HIV-1 and oncogenic virus co-infected patients, and thus elucidation of the molecular mechanisms for how HIV-1 expedites the oncogenic viruses-triggered tumorigenesis in the co-infected hosts is imperative for developing therapeutics to cure or impede the carcinogenesis. Hence, this review is focused on HIV-1 and oncogenic virus co-infection-mediated molecular processes in the acceleration of non-AIDS-defining cancers.

Description

Citation

Proulx, J., Ghaly, M., Park, I. W., & Borgmann, K. (2022). HIV-1-Mediated Acceleration of Oncovirus-Related Non-AIDS-Defining Cancers. Biomedicines, 10(4), 768. https://doi.org/10.3390/biomedicines10040768