Role of Virally-Encoded Deubiquitinating Enzymes in Regulation of the Virus Life Cycle
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0000-0002-5452-0461 (Proulx, Jessica)
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Abstract
The ubiquitin (Ub) proteasome system (UPS) plays a pivotal role in regulation of numerous cellular processes, including innate and adaptive immune responses that are essential for restriction of the virus life cycle in the infected cells. Deubiquitination by the deubiquitinating enzyme, deubiquitinase (DUB), is a reversible molecular process to remove Ub or Ub chains from the target proteins. Deubiquitination is an integral strategy within the UPS in regulating survival and proliferation of the infecting virus and the virus-invaded cells. Many viruses in the infected cells are reported to encode viral DUB, and these vial DUBs actively disrupt cellular Ub-dependent processes to suppress host antiviral immune response, enhancing virus replication and thus proliferation. This review surveys the types of DUBs encoded by different viruses and their molecular processes for how the infecting viruses take advantage of the DUB system to evade the host immune response and expedite their replication.
Description
Keywords
ubiquitin proteasome system
viruses
Animals
Deubiquitinating Enzymes / chemistry
Deubiquitinating Enzymes / metabolism
Host-Pathogen Interactions / immunology
Humans
Immune Evasion
Immunity, Innate / immunology
Life Cycle Stages
Ubiquitin / metabolism
Ubiquitination
Viral Proteins / chemistry
Viral Proteins / metabolism
Virus Diseases / enzymology
Virus Diseases / immunology
Virus Diseases / virology
Virus Replication
Viruses / enzymology
Viruses / immunology