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dc.rights.licenseAttribution 4.0 International (CC BY 4.0)
dc.creatorPan, Mengxiong
dc.creatorWang, Peng
dc.creatorZheng, Chengcai
dc.creatorZhang, Hongxia
dc.creatorLin, Siyang
dc.creatorShao, Bei
dc.creatorZhuge, Qichuan
dc.creatorJin, Kunlin
dc.identifier.citationPan, M., Wang, P., Zheng, C., Zhang, H., Lin, S., Shao, B., Zhuge, Q., & Jin, K. (2017). Aging Systemic Milieu Impairs Outcome after Ischemic Stroke in Rats. Aging and disease, 8(5), 519-530.
dc.description.abstractCompelling evidence indicates that factors in the blood can profoundly reverse aging-related impairments, as exposure of aged mice to young blood rejuvenates adult stem cell function, improves cognition, and ameliorates cardiac hypertrophy. Systemic factors from mice can also extend the life span of a partner exposed to a lethal treatment or disease. These findings suggest that the systemic milieu of a healthy young partner may be beneficial for an aged organism. However, it is unknown whether a healthy young systemic milieu can improve functional recovery after ischemic stroke. Intraperitoneal administration of young plasma into aged rats after ischemic stroke induced by distal middle cerebral artery occlusion (dMCAO) reduced infarct volume and motor impairment, compared with vehicle group. On the contrary, intraperitoneal administration of plasma from aged rats into young ischemic rats worsened brain injury and motor deficits. Using a proteomic approach, we found that haptoglobin levels were significantly increased in serum of aged rats and that intraperitoneal administration of haptoglobin impaired outcome after ischemic stroke in young rats. Our data suggest that the aging systemic milieu plays a critical role in functional outcome after ischemic stroke.
dc.description.sponsorshipThis work was supported by National Institute of Health (NIH) grants R21NS094859 and AG21980.
dc.publisherJKL International
dc.sourceAging and Disease
dc.subjectischemic stroke
dc.subjectsystemic milieu
dc.titleAging Systemic Milieu Impairs Outcome after Ischemic Stroke in Rats
dc.rights.holder© 2017 Pan M, et al.
dc.creator.orcid0000-0002-1336-348X (Jin, Kunlin)
dc.creator.orcid0000-0003-1594-6707 (Zhang, Hongxia)

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Attribution 4.0 International (CC BY 4.0)
Except where otherwise noted, this item's license is described as Attribution 4.0 International (CC BY 4.0)