Key Signaling Pathways in Aging and Potential Interventions for Healthy Aging
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Authors
ORCID
0000-0003-1594-6707 (Zhang, Hongxia)
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Abstract
Aging is a fundamental biological process accompanied by a general decline in tissue function. Indeed, as the lifespan increases, age-related dysfunction, such as cognitive impairment or dementia, will become a growing public health issue. Aging is also a great risk factor for many age-related diseases. Nowadays, people want not only to live longer but also healthier. Therefore, there is a critical need in understanding the underlying cellular and molecular mechanisms regulating aging that will allow us to modify the aging process for healthy aging and alleviate age-related disease. Here, we reviewed the recent breakthroughs in the mechanistic understanding of biological aging, focusing on the adenosine monophosphate-activated kinase (AMPK), Sirtuin 1 (SIRT1) and mammalian target of rapamycin (mTOR) pathways, which are currently considered critical for aging. We also discussed how these proteins and pathways may potentially interact with each other to regulate aging. We further described how the knowledge of these pathways may lead to new interventions for antiaging and against age-related disease.
Description
Keywords
ampk
sirt1
aging
health span
intervention
mTOR
senescence
signaling
AMP-Activated Protein Kinases / metabolism
Age Factors
Animals
Biomarkers / metabolism
Cognition / drug effects
Cognitive Aging
Enzyme Activation
Enzyme Activators / therapeutic use
Functional Status
Healthy Aging / drug effects
Healthy Aging / metabolism
Healthy Aging / psychology
Humans
Mental Health
Molecular Targeted Therapy
Protein Kinase Inhibitors / therapeutic use
Signal Transduction / drug effects
Sirtuin 1 / metabolism
TOR Serine-Threonine Kinases / antagonists & inhibitors
TOR Serine-Threonine Kinases / metabolism