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dc.rights.licenseAttribution 4.0 International (CC BY 4.0)
dc.creatorKasanga, Ella A.
dc.creatorLittle, Joel
dc.creatorMcInnis, Tamara R.
dc.creatorBugnariu, Nicoleta
dc.creatorCunningham, J. Thomas
dc.creatorSalvatore, Michael F.
dc.date.accessioned2022-11-21T22:08:58Z
dc.date.available2022-11-21T22:08:58Z
dc.date.issued2021-12-15
dc.identifier.citationKasanga, E. A., Little, J., McInnis, T. R., Bugnariu, N., Cunningham, J. T., & Salvatore, M. F. (2021). Cardiovascular Metrics Associated With Prevention of Aging-Related Parkinsonian Signs Following Exercise Intervention in Sedentary Older Rats. Frontiers in aging neuroscience, 13, 775355. https://doi.org/10.3389/fnagi.2021.775355
dc.identifier.issn1663-4365
dc.identifier.urihttps://hdl.handle.net/20.500.12503/31961
dc.description.abstractPreservation of motor capabilities is vital to maintaining independent daily living throughout a person's lifespan and may mitigate aging-related parkinsonism, a progressive and prevalent motor impairment. Physically active lifestyles can mitigate aging-related motor impairment. However, the metrics of physical activity necessary for mitigating parkinsonian signs are not established. Consistent moderate intensity (~10 m/min) treadmill exercise can reverse aging-related parkinsonian signs by 20 weeks in a 2-week on, 2-week off, regimen in previously sedentary advanced middle-aged rats. In this study, we initiated treadmill exercise in sedentary 18-month-old male rats to address two questions: (1) if a rest period not longer than 1-week off exercise, with 15 exercise sessions per month, could attenuate parkinsonian signs within 2 months after exercise initiation, and the associated impact on heart rate (HR) and mean arterial pressure (MAP) and (2) if continuation of this regimen, up to 20 weeks, will be associated with continual prevention of parkinsonian signs. The intensity and frequency of treadmill exercise attenuated aging-related parkinsonian signs by 8 weeks and were maintained till 23 months old. The exercise regimen increased HR by 25% above baseline and gradually reduced pre-intervention MAP. Together, these studies indicate that a practicable frequency and intensity of exercise reduces parkinsonian sign severity commensurate with a modest increase in HR after exercise. These cardiovascular changes provide a baseline of metrics, easily measured in humans, for predictive validity that practicable exercise intensity and schedule can be initiated in previously sedentary older adults to delay the onset of aging-related parkinsonian signs.
dc.description.sponsorshipThis work was supported by the National Institute on Aging (NIH grant AG040261) to MS and intramural grant funding to MS, JC, and NB by the Institute for Healthy Aging at the University of North Texas Health Science Center. EK was supported by the Office of Vice President for Research and Innovation, the Institute for Healthy Aging, and the National Institutes of Health/National Institute on Aging (T32 AG020494).
dc.publisherFrontiers Media S.A.
dc.relation.urihttps://doi.org/10.3389/fnagi.2021.775355
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceFrontiers in Aging Neuroscience
dc.subjectaging
dc.subjectexercise
dc.subjectheart rate
dc.subjectparkinsonism
dc.subjectpredictive validity
dc.titleCardiovascular Metrics Associated With Prevention of Aging-Related Parkinsonian Signs Following Exercise Intervention in Sedentary Older Rats
dc.typeArticle
dc.rights.holderCopyright © 2021 Kasanga, Little, McInnis, Bugnariu, Cunningham and Salvatore.
dc.type.materialtext
dc.creator.orcid0000-0001-8859-9481 (Cunningham, J. Thomas)
dc.identifier.volume13


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Attribution 4.0 International (CC BY 4.0)
Except where otherwise noted, this item's license is described as Attribution 4.0 International (CC BY 4.0)