Neurobehavioral and biochemical consequences of chronic, low-dose methamphetamine exposure in male and female mice

dc.contributor.advisorSumien, Nathalie
dc.contributor.committeeMemberHuang, Ren-Qi
dc.contributor.committeeMemberGatch, Michael B.
dc.contributor.committeeMemberPhillips, Nicole R.
dc.contributor.committeeMemberSchreihofer, Derek A.
dc.contributor.committeeMemberMa, Rong
dc.creatorDavis, Delaney L.
dc.date.accessioned2024-02-06T22:28:00Z
dc.date.available2024-02-06T22:28:00Z
dc.date.issued2022-08
dc.description.abstractAlthough prescription psychostimulants are effective in reducing attention deficit hyperactivity disorder (ADHD) symptomology, misuse of these drugs can pose serious risks such as potential abuse, dependence, and/or neurotoxicity. Of particular concern is that young adults have the highest prevalence of prescription stimulant misuse, with almost 10% of college students admitting to using amphetamine (e.g. Adderall) or methylphenidate (e.g. Ritalin) products. Despite these drugs being widely used for therapeutic and recreational use, the long-term effects of prescription stimulants have not been systematically evaluated in controlled clinical trials. Therefore, it is critical to conduct this research because young adults may be a vulnerable, at-risk population to the potential adverse consequences of long-term amphetamine use. This dissertation research evaluates the biochemical and behavioral consequences of chronic exposure of the prototypical psychostimulant, methamphetamine (METH), in a rodent model. It is hypothesized that repeated doses of METH, within the therapeutic dosing range used in a clinical setting, will induce neurotoxicity through the interplay of biological mechanisms of oxidative stress, glutamate excitotoxicity, neuroinflammation and epigenetic alterations and increase susceptibility to addiction that will be exacerbated by aging processes. Overall, the body of results showed short-term alterations in brain biochemistry and behavioral function, that do not necessarily persist past 5 months after METH treatment. In conclusion, this dissertation highlights the importance of long-term studies in addressing prescription stimulant misuse in an adult population to better understand the safety of these widely used and prescribed psychostimulants.
dc.format.mimetypeapplication/pdf
dc.identifier.urihttps://hdl.handle.net/20.500.12503/32482
dc.language.isoen
dc.subjectaging
dc.subjectcognition
dc.subjectmethamphetamine
dc.subjectmice
dc.subjectmotor function
dc.subjectoxidative stress
dc.subjectpsychostimulants
dc.subject.meshMethamphetamine
dc.subject.meshCognition
dc.subject.meshAging
dc.titleNeurobehavioral and biochemical consequences of chronic, low-dose methamphetamine exposure in male and female mice
dc.typeThesis
dc.type.materialtext
thesis.degree.departmentSchool of Biomedical Sciences
thesis.degree.disciplineBiomedical Sciences
thesis.degree.grantorUniversity of North Texas Health Science Center at Fort Worth
thesis.degree.nameDoctor of Philosophy

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