The Functional Role of Lectin-like Transcript 1 (LLT1) in Hepatocellular Carcinoma

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dc.contributor.advisorMathew, Stephen O.
dc.contributor.committeeMemberSankpal, Umesh
dc.contributor.committeeMemberBasha, Riyaz
dc.contributor.committeeMemberChaudhary, Pankaj
dc.contributor.committeeMemberJones, Harlan P.
dc.creatorPerkins, Joshua
dc.date.accessioned2024-08-22T19:55:05Z
dc.date.available2024-08-22T19:55:05Z
dc.date.issued2023-08
dc.description.abstractHepatocellular carcinoma (HCC) is a global leading cause of cancer-related deaths. Current treatments for HCC are ineffective. Transplantation and surgical resection are the only curative options, however, only an approximate 3% of HCC patients are eligible. Without transplantation or resection, the 5-year, overall survival (OS) rates remain <10%, with death 6-18 months from diagnosis. Cancer immunotherapy provides an avenue to investigate potential treatments as immunotherapies can promote immune-mediated tumor lysis, while sparing patients from some of the toxic effects of radiation and chemotherapy. Prior research suggests the inhibitory mechanisms underlying the LLT1/NKR-P1A interaction attributes to cancer growth as it allows the cancer to evade immune surveillance. Studies demonstrate improved NK cell activity and NK cell-mediated tumor lysis upon applying LLT1 blockades in prostate, breast, and hematological cancers. The goal of this project was to similarly evaluate the role of LLT1 in HCC.
dc.format.mimetypeapplication/pdf
dc.identifier.urihttps://hdl.handle.net/20.500.12503/32898
dc.language.isoen
dc.subjecthepatocellular carcinoma (HCC)
dc.subjectlectin-like transcript 1 (LLt1)
dc.subjectprogrammed death-ligand 1 (PD-L1)
dc.subjectcancer immunotherapy
dc.subject.meshCarcinoma, Hepatocellular
dc.subject.meshReceptors, NK Cell Lectin-Like
dc.subject.meshB7-H1 Antigen
dc.titleThe Functional Role of Lectin-like Transcript 1 (LLT1) in Hepatocellular Carcinoma
dc.typeThesis
dc.type.materialtext
thesis.degree.departmentSchool of Biomedical Sciences
thesis.degree.disciplineClinical Research Management
thesis.degree.grantorUniversity of North Texas Health Science Center at Fort Worth
thesis.degree.nameMaster of Science

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