The Effect of Lymphatic Pump Treatment on Anti-Tumor Immune Responses

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dc.contributor.advisorHodge, Lisa M.
dc.creatorMcCauley, Lyndsey R.
dc.date.accessioned2019-08-22T19:38:22Z
dc.date.available2019-08-22T19:38:22Z
dc.date.issued2011-05-01
dc.date.submitted2012-11-20T10:15:33-08:00
dc.description.abstractThe lymphatic system’s significance in maintaining health has been focused on by the osteopathic medical profession for years. Osteopathic manipulative treatments (OMT), specifically lymphatic pump techniques (LPT), aim at increasing lymphatic circulation and improving the clearance of interstitial fluid, inflammatory agents, and protein from the interstitial space. However, certain osteopathic manipulative techniques, such as LPT, are contraindicated in the presence of cancer with metastatic potential because it is thought that by accelerating the flow of lymph through the lymphatic vessels, tumor cells may metastasize throughout the body via the lymphatics. However, this theory lacks scientific proof. Studies previously conducted by our lab show that LPT increases thoracic duct lymph flow and leukocyte numbers in the rat and significantly decreases solid tumor formation and increases leukocyte concentrations in the lungs of rats with tumors (unpublished data). It is possible that increased lymph flow along with an increased number of circulating leukocytes can improve immune surveillance, providing recognition of and protection against pathogens and disease. Therefore, we hypothesized that administration of LPT would enhance anti-tumor immune responses in the lungs of rats with pulmonary tumors. In order to test this hypothesis, this thesis focused on one specific aim: to determine if LPT enhances leukocyte activation and/or function, thereby enhancing anti-tumor activities, such as tumor lysis and cytokine secretion.
dc.format.mimetypeapplication/pdf
dc.identifier.urihttps://hdl.handle.net/20.500.12503/26535
dc.language.isoen
dc.provenance.legacyDownloads3
dc.subjectBiological Phenomena, Cell Phenomena, and Immunity
dc.subjectMedical Biotechnology
dc.subjectNeoplasms
dc.subjectOsteopathic Manipulation
dc.subjectlymphatic pump treatment
dc.subjectimmunity
dc.titleThe Effect of Lymphatic Pump Treatment on Anti-Tumor Immune Responses
dc.typeThesis
dc.type.materialtext
thesis.degree.departmentGraduate School of Biomedical Sciences
thesis.degree.disciplineMicrobiology and Immunology
thesis.degree.grantorUniversity of North Texas Health Science Center at Fort Worth
thesis.degree.nameMaster of Science

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